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Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7.
Finch A, Davis W, Carter WG, Saklatvala J. Finch A, et al. Biochem J. 2001 Jan 15;353(Pt 2):275-81. doi: 10.1042/0264-6021:3530275. Biochem J. 2001. PMID: 11139391 Free PMC article.
This distribution of active JNK isoforms probably results from a different expression of JNKs within the tissues, rather than from a selective activation of isoforms. ...Cultured cells might represent a 'repair' phenotype that undergoes a broader set o …
This distribution of active JNK isoforms probably results from a different expression of JNKs within the tissues, rather than from …
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.
Lasa M, Mahtani KR, Finch A, Brewer G, Saklatvala J, Clark AR. Lasa M, et al. Mol Cell Biol. 2000 Jun;20(12):4265-74. doi: 10.1128/mcb.20.12.4265-4274.2000. Mol Cell Biol. 2000. PMID: 10825190 Free PMC article.
The chimeric transcript was stabilized by a constitutively active form of MAPK kinase 6, an activator of p38. This stabilization was blocked by SB203580, an inhibitor of p38, and by two different dominant negative forms of MAPK-activated protein kinase 2 (MAPKAPK-2), a
The chimeric transcript was stabilized by a constitutively active form of MAPK kinase 6, an activator of p38. This stabilization was …
Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor.
Saklatvala J, Dean J, Finch A. Saklatvala J, et al. Biochem Soc Symp. 1999;64:63-77. Biochem Soc Symp. 1999. PMID: 10207621 Review.
Cultured cells show a broader spectrum of kinase activation by IL-1 than tissues in vivo, suggesting that the receptors connect to more pathways in proliferating cells than in resting differentiated cells. ...
Cultured cells show a broader spectrum of kinase activation by IL-1 than tissues in vivo, suggesting that the receptors connect to mo …
Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases.
Finch AR, Caunt CJ, Perrett RM, Tsaneva-Atanasova K, McArdle CA. Finch AR, et al. Cell Signal. 2012 May;24(5):1002-11. doi: 10.1016/j.cellsig.2011.12.021. Epub 2012 Jan 3. Cell Signal. 2012. PMID: 22245064 Free PMC article.
We have explored the possible role of dual specificity phosphatases (DUSPs) on acute EGF-mediated ERK signalling using high content imaging and a delayed MEK inhibition protocol to distinguish direct and indirect effects of the phosphatases on ERK activity. ...A sim …
We have explored the possible role of dual specificity phosphatases (DUSPs) on acute EGF-mediated ERK signalling using high content imaging …
Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization.
Caunt CJ, Finch AR, Sedgley KR, Oakley L, Luttrell LM, McArdle CA. Caunt CJ, et al. J Biol Chem. 2006 Feb 3;281(5):2701-10. doi: 10.1074/jbc.M507242200. Epub 2005 Nov 28. J Biol Chem. 2006. PMID: 16314413
Regulation of gonadotropin-releasing hormone receptors by protein kinase C: inside out signalling and evidence for multiple active conformations.
Caunt CJ, Hislop JN, Kelly E, Matharu AL, Green LD, Sedgley KR, Finch AR, McArdle CA. Caunt CJ, et al. Endocrinology. 2004 Aug;145(8):3594-602. doi: 10.1210/en.2004-0092. Epub 2004 Apr 1. Endocrinology. 2004. PMID: 15059960
A dominant-negative dynamin mutant (K44A) inhibited internalization of XGnRH-Rs (but not hGnRH-Rs) without influencing PKC regulation of XGnRH-R binding. ...Thus, it appears that there are two distinct active conformations of XGnRH-Rs (differing in affinity for type I and
A dominant-negative dynamin mutant (K44A) inhibited internalization of XGnRH-Rs (but not hGnRH-Rs) without influencing PKC regulation
Plasma membrane expression of gonadotropin-releasing hormone receptors: regulation by peptide and nonpeptide antagonists.
Finch AR, Caunt CJ, Armstrong SP, McArdle CA. Finch AR, et al. Mol Endocrinol. 2010 Feb;24(2):423-35. doi: 10.1210/me.2009-0343. Epub 2009 Dec 15. Mol Endocrinol. 2010. PMID: 20009083 Free PMC article.
However, when the C-terminal tail of a Xenopus (X) GnRHR was added (h.XGnRHR) to increase expression, both peptides further increased cell surface GnRHR. Cetrorelix also synergized with IN3 to increase expression of hGnRHR and a G-protein coupling-deficient mutant ( …
However, when the C-terminal tail of a Xenopus (X) GnRHR was added (h.XGnRHR) to increase expression, both peptides further increased …
Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors.
Finch AR, Caunt CJ, Armstrong SP, McArdle CA. Finch AR, et al. Am J Physiol Cell Physiol. 2009 Sep;297(3):C591-600. doi: 10.1152/ajpcell.00166.2009. Epub 2009 Jul 8. Am J Physiol Cell Physiol. 2009. PMID: 19587220 Free PMC article.
Agonist effects on internalization (of h.XGnRHR) and downregulation (of hGnRHR and h.XGnRHR) were not mimicked by a peptide antagonist and were prevented by a mutation that prevents GnRHR signaling, demonstrating dependence on receptor signaling as well as agonist o …
Agonist effects on internalization (of h.XGnRHR) and downregulation (of hGnRHR and h.XGnRHR) were not mimicked by a peptide antagonis …
GnRH receptor signalling to ERK: kinetics and compartmentalization.
Caunt CJ, Finch AR, Sedgley KR, McArdle CA. Caunt CJ, et al. Trends Endocrinol Metab. 2006 Oct;17(8):308-13. doi: 10.1016/j.tem.2006.08.001. Epub 2006 Aug 21. Trends Endocrinol Metab. 2006. PMID: 16919966 Review.
Gonadotropin-releasing hormone (GnRH) receptors are seven-transmembrane receptors that have undergone a period of rapidly accelerated molecular evolution in which the advent of type I mammalian GnRH receptors has been associated with the loss of the carboxyl-terminal tail, …
Gonadotropin-releasing hormone (GnRH) receptors are seven-transmembrane receptors that have undergone a period of rapidly accelerated …
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