Fingar DC - Search Results

1

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding.

Dunlop EA, Hunt DK, Acosta-Jaquez HA, Fingar DC, Tee AR. Dunlop EA, et al. Among authors: fingar dc. Autophagy. 2011 Jul;7(7):737-47. doi: 10.4161/auto.7.7.15491. Epub 2011 Jul 1. Autophagy. 2011. PMID: 21460630 Free PMC article.

2

Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC. Acosta-Jaquez HA, et al. Among authors: fingar dc. Mol Cell Biol. 2009 Aug;29(15):4308-24. doi: 10.1128/MCB.01665-08. Epub 2009 Jun 1. Mol Cell Biol. 2009. PMID: 19487463 Free PMC article.

3

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.

Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. Foster KG, et al. Among authors: fingar dc. J Biol Chem. 2010 Jan 1;285(1):80-94. doi: 10.1074/jbc.M109.029637. Epub 2009 Oct 28. J Biol Chem. 2010. PMID: 19864431 Free PMC article.

4

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action.

Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC. Soliman GA, et al. Among authors: fingar dc. J Biol Chem. 2010 Mar 12;285(11):7866-79. doi: 10.1074/jbc.M109.096222. Epub 2009 Dec 18. J Biol Chem. 2010. PMID: 20022946 Free PMC article.

5

mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes.

Soliman GA, Acosta-Jaquez HA, Fingar DC. Soliman GA, et al. Among authors: fingar dc. Lipids. 2010 Dec;45(12):1089-100. doi: 10.1007/s11745-010-3488-y. Epub 2010 Nov 2. Lipids. 2010. PMID: 21042876 Free PMC article.

6

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PP. Carriere A, et al. Among authors: fingar dc. J Biol Chem. 2011 Jan 7;286(1):567-77. doi: 10.1074/jbc.M110.159046. Epub 2010 Nov 11. J Biol Chem. 2011. PMID: 21071439 Free PMC article.

7

mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.

Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC. Ekim B, et al. Among authors: fingar dc. Mol Cell Biol. 2011 Jul;31(14):2787-801. doi: 10.1128/MCB.05437-11. Epub 2011 May 16. Mol Cell Biol. 2011. PMID: 21576368 Free PMC article.

8

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tee AR, et al. Among authors: fingar dc. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6. doi: 10.1073/pnas.202476899. Epub 2002 Sep 23. Proc Natl Acad Sci U S A. 2002. PMID: 12271141 Free PMC article.

9

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E.

Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. Fingar DC, et al. Mol Cell Biol. 2004 Jan;24(1):200-16. doi: 10.1128/MCB.24.1.200-216.2004. Mol Cell Biol. 2004. PMID: 14673156 Free PMC article.

10

Bodur C, Kazyken D, Huang K, Ekim Ustunel B, Siroky KA, Tooley AS, Gonzalez IE, Foley DH, Acosta-Jaquez HA, Barnes TM, Steinl GK, Cho KW, Lumeng CN, Riddle SM, Myers MG Jr, Fingar DC. Bodur C, et al. Among authors: fingar dc. EMBO J. 2018 Jan 4;37(1):19-38. doi: 10.15252/embj.201696164. Epub 2017 Nov 17. EMBO J. 2018. PMID: 29150432 Free PMC article.

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