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Differentiated structure and function of cultures from human tracheal epithelium.
Yamaya M, Finkbeiner WE, Chun SY, Widdicombe JH. Yamaya M, et al. Among authors: finkbeiner we. Am J Physiol. 1992 Jun;262(6 Pt 1):L713-24. doi: 10.1152/ajplung.1992.262.6.L713. Am J Physiol. 1992. PMID: 1616056
Here we describe the conditions which allow cultured human tracheal epithelial cells to retain the ion transport properties and ultrastructure of the original tissue. ...
Here we describe the conditions which allow cultured human tracheal epithelial cells to retain the ion transport properties and ultra …
Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function.
Widdicombe JH, Sachs LA, Morrow JL, Finkbeiner WE. Widdicombe JH, et al. Among authors: finkbeiner we. Biotechniques. 2005 Aug;39(2):249-55. doi: 10.2144/05392RR02. Biotechniques. 2005. PMID: 16116798
We have developed a technique for expanding primary cultures of human tracheal epithelium while minimizing loss of differentiated structure and function. ...
We have developed a technique for expanding primary cultures of human tracheal epithelium while minimizing loss of differentiated str
Cultures of human tracheal gland cells of mucous or serous phenotype.
Finkbeiner WE, Zlock LT, Mehdi I, Widdicombe JH. Finkbeiner WE, et al. In Vitro Cell Dev Biol Anim. 2010 May;46(5):450-6. doi: 10.1007/s11626-009-9262-x. Epub 2009 Dec 9. In Vitro Cell Dev Biol Anim. 2010. PMID: 19998060 Free PMC article.
In this study, by varying growth supports and media, we have produced cultures from human airway glands that in terms of their ultrastructure and secretory products resemble either mucous or serous cells. ...
In this study, by varying growth supports and media, we have produced cultures from human airway glands that in terms of their ultras …
Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function.
Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS. Song Y, et al. Among authors: finkbeiner we. Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1131-40. doi: 10.1152/ajplung.00085.2009. Epub 2009 Oct 9. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19820035 Free PMC article.
Here, we established methodology to measure ASL depth to approximately 1-microm accuracy in ex vivo fragments of freshly obtained human and pig tracheas. ...We suggest that CF lung disease may be caused by the inability of CFTR-deficient airways to increase their AS …
Here, we established methodology to measure ASL depth to approximately 1-microm accuracy in ex vivo fragments of freshly obtained hum …
Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells.
Finkbeiner WE, Zlock LT, Morikawa M, Lao AY, Dasari V, Widdicombe JH. Finkbeiner WE, et al. Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L402-14. doi: 10.1152/ajplung.00210.2010. Epub 2011 Jul 1. Am J Physiol Lung Cell Mol Physiol. 2011. PMID: 21724859 Free PMC article.
We investigated how cystic fibrosis (CF) alters the relationship between Cl(-) and mucin secretion in cultures of non-CF and CF human tracheobronchial gland mucous (HTGM and CFTGM, respectively) cells. ...We conclude that mucin secretion by cultures of human tracheo
We investigated how cystic fibrosis (CF) alters the relationship between Cl(-) and mucin secretion in cultures of non-CF and CF human
Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching.
Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS. Derichs N, et al. Among authors: finkbeiner we. FASEB J. 2011 Jul;25(7):2325-32. doi: 10.1096/fj.10-179549. Epub 2011 Mar 22. FASEB J. 2011. PMID: 21427214 Free PMC article.
We measured viscosity of the ML and PCL from the diffusion of FITC-dextran dissolved in the ASL of unperturbed, well-differentiated primary cultures of human bronchial epithelia grown at an air-liquid interface. ...We found remarkably elevated viscosity in both ML a
We measured viscosity of the ML and PCL from the diffusion of FITC-dextran dissolved in the ASL of unperturbed, well-differentiated p
CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype.
Fischer H, Illek B, Sachs L, Finkbeiner WE, Widdicombe JH. Fischer H, et al. Among authors: finkbeiner we. Am J Physiol Lung Cell Mol Physiol. 2010 Oct;299(4):L585-94. doi: 10.1152/ajplung.00421.2009. Epub 2010 Jul 30. Am J Physiol Lung Cell Mol Physiol. 2010. PMID: 20675434 Free PMC article.
Using cell culture models, we have investigated the relative importance of cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CaCC) in Cl secretion by mucous and serous cells of human airway glands. ...We conclude: 1) …
Using cell culture models, we have investigated the relative importance of cystic fibrosis transmembrane conductance regulator (CFTR) …
CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures.
Namkung W, Finkbeiner WE, Verkman AS. Namkung W, et al. Among authors: finkbeiner we. Mol Biol Cell. 2010 Aug 1;21(15):2639-48. doi: 10.1091/mbc.E09-12-1004. Epub 2010 Jun 16. Mol Biol Cell. 2010. PMID: 20554763 Free PMC article.
We found that most chloride current elicited by Ca(2+) agonists in primary cultures of human bronchial epithelial cells is mediated by CFTR by a mechanism involving Ca(2+) activation of adenylyl cyclase I (AC1) and cAMP/PKA signaling. ...We further conclude that CFT
We found that most chloride current elicited by Ca(2+) agonists in primary cultures of human bronchial epithelial cells is mediated b
In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye.
Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS. Namkung W, et al. Among authors: finkbeiner we. J Biol Chem. 2009 Jun 5;284(23):15916-26. doi: 10.1074/jbc.M808021200. Epub 2009 Apr 13. J Biol Chem. 2009. PMID: 19364771 Free PMC article.
We synthesized a two-color fluorescent dextran to measure ASL [K(+)], TAC-Lime-dextran-TMR, consisting of a green-fluorescing triazacryptand K(+) ionophore-Bodipy conjugate, coupled to dextran, together with a red fluorescing tetramethylrhodamine reference chromophore. ...
We synthesized a two-color fluorescent dextran to measure ASL [K(+)], TAC-Lime-dextran-TMR, consisting of a green-fluorescing triazac
Extrarenal tissue distribution of CHIP28 water channels by in situ hybridization and antibody staining.
Hasegawa H, Lian SC, Finkbeiner WE, Verkman AS. Hasegawa H, et al. Among authors: finkbeiner we. Am J Physiol. 1994 Apr;266(4 Pt 1):C893-903. doi: 10.1152/ajpcell.1994.266.4.C893. Am J Physiol. 1994. PMID: 7513954
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