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Page 1
Causal relationship between the immune cells and ankylosing spondylitis: univariable, bidirectional, and multivariable Mendelian randomization.
Qin C, Yu Q, Deng Z, Zhang Y, Chen M, Wang X, Hu T, Lei B, Yan Z, Cheng S. Qin C, et al. Front Immunol. 2024 Apr 9;15:1345416. doi: 10.3389/fimmu.2024.1345416. eCollection 2024. Front Immunol. 2024. PMID: 38655262 Free PMC article.
We sourced the data on immune cells from the latest genome-wide association studies (GWASs). We obtained data on AS from the FinnGen consortium. Our comprehensive univariable MR analysis covered 731 immune cells to explore its potential causal relationship with AS. ...
We sourced the data on immune cells from the latest genome-wide association studies (GWASs). We obtained data on AS from the FinnGen …
Obstructive sleep apnea and mental disorders: a bidirectional mendelian randomization study.
Liu H, Wang X, Feng H, Zhou S, Pan J, Ouyang C, Hu X. Liu H, et al. BMC Psychiatry. 2024 Apr 23;24(1):304. doi: 10.1186/s12888-024-05754-8. BMC Psychiatry. 2024. PMID: 38654235
Summary statistics on OSA and the nine mental disorders were extracted from the FinnGen study and the Psychiatric Genomics Consortium. The primary analytical approach for estimating causal effects was the inverse-variance weighted (IVW), with the weighted median and MR Egg …
Summary statistics on OSA and the nine mental disorders were extracted from the FinnGen study and the Psychiatric Genomics Consortium …
Genetic causal relationship between immune diseases and migraine: a Mendelian randomization study.
Li G, Duan S; International Headache Genetics Consortium (IHGC); Zheng T, Zhu T, Qu B, Liu L, Liu Z. Li G, et al. Front Immunol. 2024 Apr 8;15:1376698. doi: 10.3389/fimmu.2024.1376698. eCollection 2024. Front Immunol. 2024. PMID: 38650934 Free PMC article.
Summary statistics for migraine were obtained from 3 databases: the International Headache Genetics Consortium (IHGC), UK Biobank, and FinnGen study. MR analyses were performed per outcome database for each exposure and subsequently meta-analyzed. ...
Summary statistics for migraine were obtained from 3 databases: the International Headache Genetics Consortium (IHGC), UK Biobank, and Fi …
Exploring the immunological landscape of osteomyelitis through mendelian randomization analysis.
Long K, Gong A, Yu D, Dong S, Ying Z, Zhang L. Long K, et al. Front Genet. 2024 Apr 8;15:1362432. doi: 10.3389/fgene.2024.1362432. eCollection 2024. Front Genet. 2024. PMID: 38650858 Free PMC article.
Genome-Wide Association Studies (GWAS) data for immune characteristics were obtained from the public GWAS catalog, while data for osteomyelitis was sourced from the FinnGen. RESULTS: At a significance level of 0.05, 21 immune phenotypes were identified as having a causal r …
Genome-Wide Association Studies (GWAS) data for immune characteristics were obtained from the public GWAS catalog, while data for osteomyeli …
Systematic investigation of genetically determined plasma and urinary metabolites to discover potential interventional targets for colorectal cancer.
Sun J, Zhao J, Zhou S, Li X, Li T, Wang L, Yuan S, Chen D, Law PJ, Larsson SC, Farrington SM, Houlston RS, Dunlop MG, Theodoratou E, Li X. Sun J, et al. J Natl Cancer Inst. 2024 Apr 22:djae089. doi: 10.1093/jnci/djae089. Online ahead of print. J Natl Cancer Inst. 2024. PMID: 38648753
Genetic associations with CRC were obtained from a large-scale GWAS meta-analysis (100,204 cases; 154,587 controls) and the FinnGen cohort (4,957 cases; 304,197 controls). Mendelian randomization (MR) and colocalization analyses were performed to evaluate the causal roles …
Genetic associations with CRC were obtained from a large-scale GWAS meta-analysis (100,204 cases; 154,587 controls) and the FinnGen c …
Periodontal disease and risk of Alzheimer's disease: A two-sample Mendelian randomization.
Hu C, Li H, Huang L, Wang R, Wang Z, Ma R, Chang B, Li S, Li H, Li G. Hu C, et al. Brain Behav. 2024 Apr;14(4):e3486. doi: 10.1002/brb3.3486. Brain Behav. 2024. PMID: 38648391 Free PMC article.
However, the causal relationship between periodontal disease and AD remains to be determined. METHODS: We obtained periodontal disease data from the FinnGen database and two sets of AD data from the IEU consortium and PGC databases. ...
However, the causal relationship between periodontal disease and AD remains to be determined. METHODS: We obtained periodontal disease data …
Love-hate relationship between hepatitis B virus and type 2 diabetes: a Mendelian randomization study.
Yu Y, Tong K, Hu G, Yang X, Wu J, Bai S, Yu R. Yu Y, et al. Front Microbiol. 2024 Apr 5;15:1378311. doi: 10.3389/fmicb.2024.1378311. eCollection 2024. Front Microbiol. 2024. PMID: 38646627 Free PMC article.
METHODS: Single nucleotide polymorphisms on chronic hepatitis B (CHB), liver fibrosis, liver cirrhosis, and T2D were obtained from BioBank Japan Project, European Bioinformatics Institute, and FinnGen. Mendelian randomization was utilized to evaluate exposure-outcome causa …
METHODS: Single nucleotide polymorphisms on chronic hepatitis B (CHB), liver fibrosis, liver cirrhosis, and T2D were obtained from BioBank J …
Mendelian randomization of circulating proteome identifies IFN-γ as a druggable target in aplastic anemia.
Qin S, Jiang Y, Ou Y, Zhan Y, Ji L, Xu P, Shao X, Chen H, Chen T, Cheng Y. Qin S, et al. Ann Hematol. 2024 Apr 22. doi: 10.1007/s00277-024-05746-4. Online ahead of print. Ann Hematol. 2024. PMID: 38644415
The effect of these druggable protein levels on AA risk was measured using the summary statistics from a large-scale proteomic genome-wide association study (GWAS) and FinnGen database ( https://www.finngen.fi/en/access_results ). Multivariable MR analyses were perf …
The effect of these druggable protein levels on AA risk was measured using the summary statistics from a large-scale proteomic genome-wide a …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babić D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C, Bierer LM, Biernacka JM, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Brandolino A, Breen G, Bressan RA, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum AD, Børte S, Cahn L, Calabrese JR, Caldas-de-Almeida JM, Chatzinakos C, Cheema S, Clouston SAP, Colodro-Conde L, Coombes BJ, Cruz-Fuentes CS, Dale AM, Dalvie S, Davis LK, Deckert J, Delahanty DL, Dennis MF, Desarnaud F, DiPietro CP, Disner SG, Docherty AR, Domschke K, Dyb G, Kulenović AD, Edenberg HJ, Evans A, Fabbri C, Fani N, Farrer LA, Feder A, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goleva SB, Gordon SD, Goçi A, Grasser LR, Guindalini C, Haas M, Hagenaars S, Hauser MA, Heath AC, Hemmings SMJ, Hesselbrock V, Hickie IB, Hogan K, Hougaard DM, Huang H, Huckins LM, Hveem K, Jakovljević M, Javanbakht A, Jenkins GD, Johnson J, Jones I, Jovanovic T, … See abstract for full author list ➔ Nievergelt CM, et al. Nat Genet. 2024 Apr 18. doi: 10.1038/s41588-024-01707-9. Online ahead of print. Nat Genet. 2024. PMID: 38637617
Causal effects of neuroticism on postpartum depression: a bidirectional mendelian randomization study.
Hu Q, Chen J, Ma J, Li Y, Xu Y, Yue C, Cong E. Hu Q, et al. Arch Womens Ment Health. 2024 Apr 18. doi: 10.1007/s00737-024-01466-w. Online ahead of print. Arch Womens Ment Health. 2024. PMID: 38634868
METHODS: This study utilized large-scale genome-wide association study genetic pooled data from three major databases: the United Kingdom Biobank, the European Bioinformatics Institute, and the FinnGen databases. The causal analysis methods used inverse variance weighting …
METHODS: This study utilized large-scale genome-wide association study genetic pooled data from three major databases: the United Kingdom Bi …
1,002 results