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Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity.
Finucane OM, Lyons CL, Murphy AM, Reynolds CM, Klinger R, Healy NP, Cooke AA, Coll RC, McAllan L, Nilaweera KN, O'Reilly ME, Tierney AC, Morine MJ, Alcala-Diaz JF, Lopez-Miranda J, O'Connor DP, O'Neill LA, McGillicuddy FC, Roche HM. Finucane OM, et al. Diabetes. 2015 Jun;64(6):2116-28. doi: 10.2337/db14-1098. Epub 2015 Jan 27. Diabetes. 2015. PMID: 25626736
Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice.
McGillicuddy FC, Reynolds CM, Finucane O, Coleman E, Harford KA, Grant C, Sergi D, Williams LM, Mills KH, Roche HM. McGillicuddy FC, et al. Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E834-44. doi: 10.1152/ajpendo.00297.2013. Epub 2013 Aug 6. Am J Physiol Endocrinol Metab. 2013. PMID: 23921145 Free PMC article.
High-Density Lipoprotein Proteomic Composition, and not Efflux Capacity, Reflects Differential Modulation of Reverse Cholesterol Transport by Saturated and Monounsaturated Fat Diets.
O'Reilly M, Dillon E, Guo W, Finucane O, McMorrow A, Murphy A, Lyons C, Jones D, Ryan M, Gibney M, Gibney E, Brennan L, de la Llera Moya M, Reilly MP, Roche HM, McGillicuddy FC. O'Reilly M, et al. Circulation. 2016 May 10;133(19):1838-50. doi: 10.1161/CIRCULATIONAHA.115.020278. Epub 2016 Apr 14. Circulation. 2016. PMID: 27081117 Free PMC article.
A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling.
Healy NP, Kirwan AM, McArdle MA, Holohan K, Nongonierma AB, Keane D, Kelly S, Celkova L, Lyons CL, McGillicuddy FC, Finucane OM, Murray BA, Kelly PM, Brennan L, FitzGerald RJ, Roche HM. Healy NP, et al. Among authors: finucane om. Mol Nutr Food Res. 2016 Nov;60(11):2421-2432. doi: 10.1002/mnfr.201501054. Epub 2016 Sep 8. Mol Nutr Food Res. 2016. PMID: 27390025
15 results