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DNA transformation.
Mello C, Fire A. Mello C, et al. Among authors: fire a. Methods Cell Biol. 1995;48:451-82. Methods Cell Biol. 1995. PMID: 8531738 Review. No abstract available.
An Abundant Class of Non-coding DNA Can Prevent Stochastic Gene Silencing in the C. elegans Germline.
Frøkjær-Jensen C, Jain N, Hansen L, Davis MW, Li Y, Zhao D, Rebora K, Millet JRM, Liu X, Kim SK, Dupuy D, Jorgensen EM, Fire AZ. Frøkjær-Jensen C, et al. Among authors: fire az. Cell. 2016 Jul 14;166(2):343-357. doi: 10.1016/j.cell.2016.05.072. Epub 2016 Jun 30. Cell. 2016. PMID: 27374334 Free PMC article.
Among endogenous genes, intron length and PATC-character undergo dramatic changes as orthologs move from active to repressive chromatin over evolutionary time, indicating a dynamic character to the An/Tn periodicity. We propose that PATCs form the basis of a cellula …
Among endogenous genes, intron length and PATC-character undergo dramatic changes as orthologs move from active to repressive chromatin over …
Protection from feed-forward amplification in an amplified RNAi mechanism.
Pak J, Maniar JM, Mello CC, Fire A. Pak J, et al. Among authors: fire a. Cell. 2012 Nov 9;151(4):885-899. doi: 10.1016/j.cell.2012.10.022. Cell. 2012. PMID: 23141544 Free PMC article.
The effectiveness of RNA interference (RNAi) in many organisms is potentiated through the signal-amplifying activity of a targeted RNA-directed RNA polymerase (RdRP) system that can convert a small population of exogenously-encountered dsRNA fragments into an abunda …
The effectiveness of RNA interference (RNAi) in many organisms is potentiated through the signal-amplifying activity of a targeted RN …
A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.
Drake M, Furuta T, Suen KM, Gonzalez G, Liu B, Kalia A, Ladbury JE, Fire AZ, Skeath JB, Arur S. Drake M, et al. Among authors: fire az. Dev Cell. 2014 Dec 8;31(5):614-28. doi: 10.1016/j.devcel.2014.11.004. Dev Cell. 2014. PMID: 25490268 Free PMC article.
The conserved Dicer residues, their phosphorylation by ERK, and the consequences of the resulting modifications implicate an ERK-Dicer nexus as a fundamental component of the oocyte-to-embryo transition and an underlying mechanism coupling extracellular cues to small RNA p …
The conserved Dicer residues, their phosphorylation by ERK, and the consequences of the resulting modifications implicate an ERK-Dicer nexus …
Inducible systemic RNA silencing in Caenorhabditis elegans.
Timmons L, Tabara H, Mello CC, Fire AZ. Timmons L, et al. Among authors: fire az. Mol Biol Cell. 2003 Jul;14(7):2972-83. doi: 10.1091/mbc.e03-01-0858. Mol Biol Cell. 2003. PMID: 12857879 Free PMC article.
Introduction of double-stranded RNA (dsRNA) can elicit a gene-specific RNA interference response in a variety of organisms and cell types. In many cases, this response has a systemic character in that silencing of gene expression is observed in cells distal f …
Introduction of double-stranded RNA (dsRNA) can elicit a gene-specific RNA interference response in a variety of organisms and …
On the role of RNA amplification in dsRNA-triggered gene silencing.
Sijen T, Fleenor J, Simmer F, Thijssen KL, Parrish S, Timmons L, Plasterk RH, Fire A. Sijen T, et al. Among authors: fire a. Cell. 2001 Nov 16;107(4):465-76. doi: 10.1016/s0092-8674(01)00576-1. Cell. 2001. PMID: 11719187
Instead, a population of siRNAs (termed secondary siRNAs) appeared to derive from the action of a cellular RNA-directed RNA polymerase (RdRP) on mRNAs that are being targeted by the RNAi mechanism. The distribution of secondary siRNAs exhibited a distinct pol …
Instead, a population of siRNAs (termed secondary siRNAs) appeared to derive from the action of a cellular RNA-directed RNA po …
Vectors for low copy transformation of C. elegans.
Fire A, Kondo K, Waterston R. Fire A, et al. Nucleic Acids Res. 1990 Jul 25;18(14):4269-70. doi: 10.1093/nar/18.14.4269. Nucleic Acids Res. 1990. PMID: 2377476 Free PMC article. No abstract available.
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.
Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Grishok A, et al. Among authors: fire a. Cell. 2001 Jul 13;106(1):23-34. doi: 10.1016/s0092-8674(01)00431-7. Cell. 2001. PMID: 11461699
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments that guide mRNA destruction. ...Our findings suggest that a common processing machinery generates guide RNAs that mediate both RNAi and …
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments tha …
The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
Tabara H, Sarkissian M, Kelly WG, Fleenor J, Grishok A, Timmons L, Fire A, Mello CC. Tabara H, et al. Among authors: fire a. Cell. 1999 Oct 15;99(2):123-32. doi: 10.1016/s0092-8674(00)81644-x. Cell. 1999. PMID: 10535731
We show that rde-1 is a member of the piwi/sting/argonaute/zwille/eIF2C gene family conserved from plants to vertebrates. Interestingly, several, but not all, RNAi-deficient strains exhibit mobilization of the endogenous transposons. ...
We show that rde-1 is a member of the piwi/sting/argonaute/zwille/eIF2C gene family conserved from plants to vertebrates. Interesting …
An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.
Mickey KM, Mello CC, Montgomery MK, Fire A, Priess JR. Mickey KM, et al. Among authors: fire a. Development. 1996 Jun;122(6):1791-8. Development. 1996. PMID: 8674418
In this report, we show that APX-1 protein is expressed in the P2 blastomere and that a temperature-sensitive apx-1 mutant has a temperature-sensitive period between the 4-cell and 8-cell stages. We propose that APX-1 is part or all of the P2 signal that induces ABp …
In this report, we show that APX-1 protein is expressed in the P2 blastomere and that a temperature-sensitive apx-1 mutant has a
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