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Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.
Marconett CN, Sundar SN, Tseng M, Tin AS, Tran KQ, Mahuron KM, Bjeldanes LF, Firestone GL. Marconett CN, et al. Among authors: firestone gl. Carcinogenesis. 2011 Sep;32(9):1315-23. doi: 10.1093/carcin/bgr116. Epub 2011 Jun 21. Carcinogenesis. 2011. PMID: 21693539 Free PMC article.
Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.
Garcia HH, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL. Garcia HH, et al. Among authors: firestone gl. J Biol Chem. 2005 Mar 11;280(10):8756-64. doi: 10.1074/jbc.M407957200. Epub 2004 Dec 20. J Biol Chem. 2005. PMID: 15611077 Free article.
158 results