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Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates.
Trail PA, Willner D, Lasch SJ, Henderson AJ, Hofstead S, Casazza AM, Firestone RA, Hellström I, Hellström KE. Trail PA, et al. Science. 1993 Jul 9;261(5118):212-5. doi: 10.1126/science.8327892. Science. 1993. PMID: 8327892
Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates.
Trail PA, Willner D, Knipe J, Henderson AJ, Lasch SJ, Zoeckler ME, TrailSmith MD, Doyle TW, King HD, Casazza AM, Braslawsky GR, Brown J, Hofstead SJ, Greenfield RS, Firestone RA, Mosure K, Kadow KF, Yang MB, Hellström KE, Hellström I. Trail PA, et al. Cancer Res. 1997 Jan 1;57(1):100-5. Cancer Res. 1997. PMID: 8988048
Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: A novel method for increasing the potency of doxorubicin immunoconjugates.
King HD, Yurgaitis D, Willner D, Firestone RA, Yang MB, Lasch SJ, Hellström KE, Trail PA. King HD, et al. Bioconjug Chem. 1999 Mar-Apr;10(2):279-88. doi: 10.1021/bc980100i. Bioconjug Chem. 1999. PMID: 10077478
Inhibition of antibacterial activity of himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus, by fatty acid sodium salts.
Mamber SW, Brookshire KW, Dean BJ, Firestone RA, Leet JE, Matson JA, Forenza S. Mamber SW, et al. Antimicrob Agents Chemother. 1994 Nov;38(11):2633-42. doi: 10.1128/aac.38.11.2633. Antimicrob Agents Chemother. 1994. PMID: 7872760 Free PMC article.
(6-Maleimidocaproyl)hydrazone of doxorubicin--a new derivative for the preparation of immunoconjugates of doxorubicin.
Willner D, Trail PA, Hofstead SJ, King HD, Lasch SJ, Braslawsky GR, Greenfield RS, Kaneko T, Firestone RA. Willner D, et al. Bioconjug Chem. 1993 Nov-Dec;4(6):521-7. doi: 10.1021/bc00024a015. Bioconjug Chem. 1993. PMID: 7508268
Improved cytotoxicity of antitumor compounds deliverable by the LDL pathway.
Dubowchik GM, Firestone RA. Dubowchik GM, et al. Bioconjug Chem. 1995 Jul-Aug;6(4):427-39. doi: 10.1021/bc00034a013. Bioconjug Chem. 1995. PMID: 7578363
Two of these compounds are significantly superior to the best one from our earlier study [Firestone et al. (1984) J. Med. Chem. 27, 1037-1043], being cytotoxic in rLDL at concentrations reasonably attainable in vivo....
Two of these compounds are significantly superior to the best one from our earlier study [Firestone et al. (1984) J. Med. Chem. 27, 1 …
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