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Year Number of Results
1998 1
2011 2
2014 2
2015 1
2016 3
2017 5
2018 10
2019 10
2020 16
2021 23
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2024 27
2025 4

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134 results

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Page 1
Development of Potent and Selective CK1α Molecular Glue Degraders.
Geng Q, Jiang Z, Byun WS, Donovan KA, Zhuang Z, Jiang F, Jones HM, Razumkov H, Tang MT, Sarott RC, Fischer ES, Corsello SM, Hinshaw SM, Gray NS. Geng Q, et al. Among authors: fischer es. J Med Chem. 2025 Jan 28. doi: 10.1021/acs.jmedchem.4c02415. Online ahead of print. J Med Chem. 2025. PMID: 39873536
The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A.
Kochen Rossi J, Nuevo-Tapioles C, O'Keefe RA, Hunkeler M, Schmoker AM, Fissore-O'Leary M, Su W, Ahearn IM, Branco C, Cheong H, Esposito D, Clotea I, Ueberheide B, Fischer ES, Philips MR. Kochen Rossi J, et al. Among authors: fischer es. Cell Rep. 2025 Jan 28;44(1):115087. doi: 10.1016/j.celrep.2024.115087. Epub 2024 Dec 19. Cell Rep. 2025. PMID: 39705142 Free article.
SMAC mimetics induce human macrophages to phagocytose live cancer cells.
Liu SY, Hulsman M, Leyendecker P, Chang E, Donovan KA, Strobel F, Dougan J, Fischer ES, Dougan M, Dougan SK, Qiang L. Liu SY, et al. Among authors: fischer es. bioRxiv [Preprint]. 2024 Nov 28:2024.11.25.625306. doi: 10.1101/2024.11.25.625306. bioRxiv. 2024. PMID: 39651304 Free PMC article. Preprint.
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development.
Fan AT, Gadbois GE, Huang HT, Chaudhry C, Jiang J, Sigua LH, Smith ER, Wu S, Poirier GJ, Dunne-Dombrink K, Goyal P, Tao AJ, Sellers WR, Fischer ES, Donovan KA, Ferguson FM. Fan AT, et al. Among authors: fischer es. Angew Chem Int Ed Engl. 2025 Jan 27;64(5):e202417272. doi: 10.1002/anie.202417272. Epub 2024 Dec 16. Angew Chem Int Ed Engl. 2025. PMID: 39602499
Discovery of electrophilic degraders that exploit SNAr chemistry.
Zhuang Z, Byun WS, Kozicka Z, Dwyer BG, Donovan KA, Jiang Z, Jones HM, Abeja DM, Nix MN, Zhong J, Słabicki M, Fischer ES, Ebert BL, Gray NS. Zhuang Z, et al. Among authors: fischer es. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.615094. doi: 10.1101/2024.09.25.615094. bioRxiv. 2024. PMID: 39386645 Free PMC article. Preprint.
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development.
Fan AT, Gadbois GE, Huang HT, Jiang J, Sigua LH, Smith ER, Wu S, Dunne-Dombrink K, Goyal P, Tao AJ, Sellers W, Fischer ES, Donovan KA, Ferguson FM. Fan AT, et al. Among authors: fischer es. bioRxiv [Preprint]. 2024 Sep 21:2024.09.17.612508. doi: 10.1101/2024.09.17.612508. bioRxiv. 2024. Update in: Angew Chem Int Ed Engl. 2025 Jan 27;64(5):e202417272. doi: 10.1002/anie.202417272. PMID: 39345570 Free PMC article. Updated. Preprint.
Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS. Hassan MM, et al. Among authors: fischer es. Eur J Med Chem. 2024 Dec 5;279:116904. doi: 10.1016/j.ejmech.2024.116904. Epub 2024 Sep 24. Eur J Med Chem. 2024. PMID: 39341093 Free article.
Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics.
Baek K, Metivier RJ, Roy Burman SS, Bushman JW, Yoon H, Lumpkin RJ, Abeja DM, Lakshminarayan M, Yue H, Ojeda S, Verano AL, Gray NS, Donovan KA, Fischer ES. Baek K, et al. Among authors: fischer es. bioRxiv [Preprint]. 2024 Oct 4:2024.09.11.612438. doi: 10.1101/2024.09.11.612438. bioRxiv. 2024. PMID: 39314457 Free PMC article. Preprint.
134 results