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2007 2
2008 2
2009 6
2010 8
2011 8
2012 12
2013 9
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Page 1
Subretinal injection in the USH1CR31∗ pig model leads to chorioretinal atrophy that limits evaluation of efficacy of an AAV-mediated gene therapy.
Nyshchuk R, Klein J, Seitz IP, Peters T, Mai M, Ardan T, Drutovič S, Levinská Bohuslavová B, Juhás Š, Juhásová J, Tütüncü Y, Nemesh Y, Reifferscheid LM, DeMott KP, Klein JJ, Nagel-Wolfrum K, Klymiuk N, Winslow AR, Motlik J, Ellederova Z, Fischer MD, Wolfrum U. Nyshchuk R, et al. Among authors: fischer md. Exp Eye Res. 2026 Jul 2;271:111151. doi: 10.1016/j.exer.2026.111151. Online ahead of print. Exp Eye Res. 2026. PMID: 42392489 Free article.
Gene therapy development for retinal diseases.
Reichel FFL, Bellingrath JS, Kiraly P, Fischer MD. Reichel FFL, et al. Among authors: fischer md. Handb Clin Neurol. 2026;218:343-364. doi: 10.1016/B978-0-443-22212-2.00016-1. Handb Clin Neurol. 2026. PMID: 42217984 Review.
[On the urgency of treating ophthalmic emergencies].
Seitz IP, Kelbsch C, Besch D, Gosheva M, Pleyer U, Tekeva-Rohrbach C, Fischer MD, Bartz-Schmidt KU, Rohrbach JM. Seitz IP, et al. Among authors: fischer md. Ophthalmologie. 2026 Mar;123(3):237-253. doi: 10.1007/s00347-026-02393-0. Epub 2026 Feb 25. Ophthalmologie. 2026. PMID: 41739160 Review. German.
Erratum zu: CRIMSON.
Lorenz K, Peters T, Holz FG; DOG AG Klinische Studienzentren. Lorenz K, et al. Ophthalmologie. 2026 Feb;123(Suppl 1):68. doi: 10.1007/s00347-025-02373-w. Ophthalmologie. 2026. PMID: 41498924 German. No abstract available.
[CRIMSON : A multicentre randomised, sham-controlled, double-masked, 72-week trial to study the safety, tolerability, pharmacokinetics, and efficacy of 3 dosing regimens of intravitreal BI 764524 in patients with moderate to severe non-proliferative diabetic retinopathy].
Lorenz K, Peters T, Holz FG; DOG AG Klinische Studienzentren. Lorenz K, et al. Ophthalmologie. 2026 Feb;123(2):123-127. doi: 10.1007/s00347-025-02345-0. Epub 2025 Nov 20. Ophthalmologie. 2026. PMID: 41263999 German. No abstract available.
Subretinal Injection Volume Correlates to Persistent Outer Retinal Thinning in the Pig Eye.
Seitz IP, Nyshchuk R, Ellederova Z, Ardan T, Juhasova J, Nemesh Y, Juhas S, Drutovic S, Süsskind D, Schnichels S, Motlik J, Klymiuk N, Wolfrum U, Post DeMott K, Klein JJ, Winslow A, Fischer MD. Seitz IP, et al. Among authors: fischer md. Invest Ophthalmol Vis Sci. 2025 Nov 3;66(14):27. doi: 10.1167/iovs.66.14.27. Invest Ophthalmol Vis Sci. 2025. PMID: 41230903 Free PMC article.
Safety and vision outcomes of subretinal gene supplementation therapy in PDE6A-associated retinitis pigmentosa: a non-randomised controlled trial.
Reichel FF, Fischer MD, Stingl K, Kuehlewein L, Seitz I, Peters T, Ziegler M, Wilhelm B, Kohl S, Weisschuh N, Martus P, Seeliger M, Muehlfriedel R, Paquet-Durand F, Tsang SH, Bartz-Schmidt KU, Ueffing M, Zrenner E, Biel M, Wissinger B, Michalakis S; RD-Cure Consortium. Reichel FF, et al. Among authors: fischer md. Br J Ophthalmol. 2026 Jan 22;110(2):173-179. doi: 10.1136/bjo-2024-326480. Br J Ophthalmol. 2026. PMID: 40825661 Free PMC article. Clinical Trial.
Gene Therapy-Associated Uveitis (GTAU): Understanding and mitigating the adverse immune response in retinal gene therapy.
Purdy R, John M, Bray A, Clare AJ, Copland DA, Chan YK, Henderson RH, Nerinckx F, Leroy BP, Yang P, Pennesi ME, MacLaren RE, Fischer MD, Dick AD, Xue K. Purdy R, et al. Among authors: fischer md. Prog Retin Eye Res. 2025 May;106:101354. doi: 10.1016/j.preteyeres.2025.101354. Epub 2025 Mar 14. Prog Retin Eye Res. 2025. PMID: 40090458 Free article. Review.
Extended phenotypic spectrum of benign yellow dot maculopathy.
Kiraly P, Birtel J, Ong AY, Ruan C, Fischer MD, Charbel Issa P. Kiraly P, et al. Among authors: fischer md. Eye (Lond). 2025 Jun;39(8):1547-1552. doi: 10.1038/s41433-024-03590-4. Epub 2025 Feb 21. Eye (Lond). 2025. PMID: 39984697 Free PMC article.
Safety of Human USH1C Transgene Expression Following Subretinal Injection in Wild-Type Pigs.
Kiraly P, Klein J, Seitz IP, Reichel FF, Peters T, Ardan T, Juhasova J, Juhás S, Ellederova Z, Nemesh Y, Nyshchuk R, Klymiuk N, Nagel-Wolfrum K, Winslow AR, Wolfrum U, Motlik J, Fischer MD. Kiraly P, et al. Among authors: fischer md. Invest Ophthalmol Vis Sci. 2025 Jan 2;66(1):48. doi: 10.1167/iovs.66.1.48. Invest Ophthalmol Vis Sci. 2025. PMID: 39836403 Free PMC article.
XOLARIS: A 24-Month, Prospective, Natural History Study of 201 Participants with Retinitis Pigmentosa GTPase Regulator-Associated X-Linked Retinitis Pigmentosa.
MacLaren RE, Duncan JL, Fischer MD, Lam BL, Meunier I, Pennesi ME, Sankila EK, Gow JA, Li J, Tsang SF; XOLARIS Study Group. MacLaren RE, et al. Among authors: fischer md. Ophthalmol Sci. 2024 Aug 13;5(1):100595. doi: 10.1016/j.xops.2024.100595. eCollection 2025 Jan-Feb. Ophthalmol Sci. 2024. PMID: 39493534 Free PMC article.
THE FIGHT INHERITED RETINAL BLINDNESS! PROJECT: A New Treatment Outcome and Natural History Registry for Inherited Retinal Disease.
Simunovic MP, Moore AT, Grigg J, Sergouniotis P, Mahroo OA, Vincent A, Singh M, Fischer MD, Edwards T, Mack H, Hogden M, Chen FK, Hewitt A, Ayton L, Leroy B, Jamieson R, Gillies MC, Barthelmes D. Simunovic MP, et al. Among authors: fischer md. Retina. 2025 Feb 1;45(2):286-295. doi: 10.1097/IAE.0000000000004296. Retina. 2025. PMID: 39418576 Free PMC article.
Real-world six-month outcomes in patients switched to faricimab following partial response to anti-VEGF therapy for neovascular age-related macular degeneration and diabetic macular oedema.
Borchert GA, Kiire CA, Stone NM, Akil H, Gkika T, Fischer MD, Xue K, Cehajic-Kapetanovic J, MacLaren RE, Charbel Issa P, Downes SM, De Silva SR. Borchert GA, et al. Among authors: fischer md. Eye (Lond). 2024 Dec;38(18):3569-3577. doi: 10.1038/s41433-024-03364-y. Epub 2024 Oct 11. Eye (Lond). 2024. PMID: 39394370 Free PMC article.
Peripapillary pachychoroid syndrome: clinical insights.
Kiraly P, Fischer MD. Kiraly P, et al. Among authors: fischer md. Eye (Lond). 2024 Dec;38(17):3210-3212. doi: 10.1038/s41433-024-03274-z. Epub 2024 Jul 31. Eye (Lond). 2024. PMID: 39085598 Free PMC article. No abstract available.
Early REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION): Study protocol of a phase III trial.
Poli S, Grohmann C, Wenzel DA, Poli K, Tünnerhoff J, Nedelmann M, Fiehler J, Burghaus I, Lehmann M, Glauch M, Schadwinkel HM, Kalmbach P, Zeller J, Peters T, Eschenfelder C, Agostini H, Campbell BC, Fischer MD, Sykora M, Mac Grory B, Feltgen N, Kowarik M, Seiffge D, Strbian D, Albrecht M, Alzureiqi MS, Auffarth G, Bäzner H, Behnke S, Berberich A, Bode F, Bohmann FO, Cheng B, Czihal M, Danyel LA, Dimopoulos S, Pinhal Ferreira de Pinho JD, Fries FN, Gamulescu MA, Gekeler F, Gomez-Exposito A, Gumbinger C, Guthoff R, Hattenbach LO, Kellert L, Khoramnia R, Kohnen T, Kürten D, Lackner B, Laible M, Lee JI, Leithner C, Liegl R, Lochner P, Mackert M, Mbroh J, Müller S, Nagel S, Prasuhn M, Purrucker J, Reich A, Mundiyanapurath S, Royl G, Salchow DJ, Schäfer JH, Schlachetzki F, Schmack I, Thomalla G, Tieck Fernandez MP, Wakili P, Walter P, Wolf A, Wolf M, Bartz-Schmidt KU, Schultheiss M, Spitzer MS. Poli S, et al. Among authors: fischer md. Int J Stroke. 2024 Aug;19(7):823-829. doi: 10.1177/17474930241248516. Epub 2024 Jun 25. Int J Stroke. 2024. PMID: 38591748 Free article.
Final 1-Year Results of the TUTOR Randomized Trial Comparing Carpal Tunnel Release with Ultrasound Guidance to Mini-open Technique.
Eberlin KR, Amis BP, Berkbigler TP, Dy CJ, Fischer MD, Gluck JL, Kaplan FTD, McDonald TJ, Miller LE, Palmer A, Perry PE, Walker ME, Watt JF. Eberlin KR, et al. Among authors: fischer md. Plast Reconstr Surg Glob Open. 2024 Mar 4;12(3):e5665. doi: 10.1097/GOX.0000000000005665. eCollection 2024 Mar. Plast Reconstr Surg Glob Open. 2024. PMID: 38440365 Free PMC article.
Morphological and functional parameters in X-linked retinoschisis patients-A multicentre retrospective cohort study.
Kiraly P, Seitz IP, Abdalla Elsayed MEA, Downes SM, Patel CK, Charbel Issa P, Birtel J, Mautone L, Dulz S, Atiskova Y, Herrmann P, Vrabič N, Jarc-Vidmar M, Hawlina M, Fischer MD. Kiraly P, et al. Among authors: fischer md. Front Med (Lausanne). 2024 Jan 11;10:1331889. doi: 10.3389/fmed.2023.1331889. eCollection 2023. Front Med (Lausanne). 2024. PMID: 38351967 Free PMC article.
Outcomes and Adverse Effects of Voretigene Neparvovec Treatment for Biallelic RPE65-Mediated Inherited Retinal Dystrophies in a Cohort of Patients from a Single Center.
Kiraly P, Cottriall CL, Taylor LJ, Jolly JK, Cehajic-Kapetanovic J, Yusuf IH, Martinez-Fernandez de la Camara C, Shanks M, Downes SM, MacLaren RE, Fischer MD. Kiraly P, et al. Among authors: fischer md. Biomolecules. 2023 Oct 5;13(10):1484. doi: 10.3390/biom13101484. Biomolecules. 2023. PMID: 37892166 Free PMC article.
Choroideremia: The Endpoint Endgame.
Abdalla Elsayed MEA, Taylor LJ, Josan AS, Fischer MD, MacLaren RE. Abdalla Elsayed MEA, et al. Among authors: fischer md. Int J Mol Sci. 2023 Sep 20;24(18):14354. doi: 10.3390/ijms241814354. Int J Mol Sci. 2023. PMID: 37762657 Free PMC article. Review.
Qualitative exploration of the visual function impairments and impacts on vision-dependent activities of daily living in Retinitis Pigmentosa and Leber Congenital Amaurosis: content validation of the ViSIO-PRO and ViSIO-ObsRO measures.
Kay C, Audo I, Naujoks C, Spera C, Fischer MD, Green J, Durham T, Williamson N, Bradley H, Barclay M, Sims J, Banhazi J, Patalano F. Kay C, et al. Among authors: fischer md. J Patient Rep Outcomes. 2023 Jul 19;7(1):74. doi: 10.1186/s41687-023-00610-x. J Patient Rep Outcomes. 2023. PMID: 37466759 Free PMC article.
Multicenter randomized trial of carpal tunnel release with ultrasound guidance versus mini-open technique.
Eberlin KR, Amis BP, Berkbigler TP, Dy CJ, Fischer MD, Gluck JL, Kaplan FTD, McDonald TJ, Miller LE, Palmer A, Perry PE, Walker ME, Watt JF. Eberlin KR, et al. Among authors: fischer md. Expert Rev Med Devices. 2023 Jul;20(7):597-605. doi: 10.1080/17434440.2023.2218548. Epub 2023 May 30. Expert Rev Med Devices. 2023. PMID: 37254502 Free article. Clinical Trial.
Development of Novel Patient-Reported Outcome (PRO) and Observer-Reported Outcome (ObsRO) Instruments in Retinitis Pigmentosa (RP) and Leber Congenital Amaurosis (LCA): ViSIO-PRO and ViSIO-ObsRO.
Audo I, Patalano F, Naujoks C, Spera C, Fischer MD, Green J, Kay C, Durham T, Williamson N, Bradley H, Barclay M, Boparai K, Banhazi J. Audo I, et al. Among authors: fischer md. Ophthalmol Ther. 2023 Aug;12(4):2069-2085. doi: 10.1007/s40123-023-00724-x. Epub 2023 May 21. Ophthalmol Ther. 2023. PMID: 37210697 Free PMC article.
[The Eye as a Window to Cystinosis].
Priglinger C, Fischer MD. Priglinger C, et al. Among authors: fischer md. Klin Monbl Augenheilkd. 2023 Mar;240(3):248-249. doi: 10.1055/a-2004-9072. Epub 2023 Mar 28. Klin Monbl Augenheilkd. 2023. PMID: 36977425 German. No abstract available.
Gene Therapy for Inherited Retinal Disease: Long-Term Durability of Effect.
Leroy BP, Fischer MD, Flannery JG, MacLaren RE, Dalkara D, Scholl HPN, Chung DC, Spera C, Viriato D, Banhazi J. Leroy BP, et al. Among authors: fischer md. Ophthalmic Res. 2023;66(1):179-196. doi: 10.1159/000526317. Epub 2022 Sep 14. Ophthalmic Res. 2023. PMID: 36103843 Free article. Review.
Development of retinal atrophy after subretinal gene therapy with voretigene neparvovec.
Reichel FF, Seitz I, Wozar F, Dimopoulos S, Jung R, Kempf M, Kohl S, Kortüm FC, Ott S, Pohl L, Stingl K, Bartz-Schmidt KU, Stingl K, Fischer MD. Reichel FF, et al. Among authors: fischer md. Br J Ophthalmol. 2023 Sep;107(9):1331-1335. doi: 10.1136/bjophthalmol-2021-321023. Epub 2022 May 24. Br J Ophthalmol. 2023. PMID: 35609955
Challenges to Gene Editing Approaches in the Retina.
Bonillo M, Pfromm J, Fischer MD. Bonillo M, et al. Among authors: fischer md. Klin Monbl Augenheilkd. 2022 Mar;239(3):275-283. doi: 10.1055/a-1757-9810. Epub 2022 Mar 22. Klin Monbl Augenheilkd. 2022. PMID: 35316854 Review. English.
Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes.
Grotz S, Schäfer J, Wunderlich KA, Ellederova Z, Auch H, Bähr A, Runa-Vochozkova P, Fadl J, Arnold V, Ardan T, Veith M, Santamaria G, Dhom G, Hitzl W, Kessler B, Eckardt C, Klein J, Brymova A, Linnert J, Kurome M, Zakharchenko V, Fischer A, Blutke A, Döring A, Suchankova S, Popelar J, Rodríguez-Bocanegra E, Dlugaiczyk J, Straka H, May-Simera H, Wang W, Laugwitz KL, Vandenberghe LH, Wolf E, Nagel-Wolfrum K, Peters T, Motlik J, Fischer MD, Wolfrum U, Klymiuk N. Grotz S, et al. Among authors: fischer md. EMBO Mol Med. 2022 Apr 7;14(4):e14817. doi: 10.15252/emmm.202114817. Epub 2022 Mar 7. EMBO Mol Med. 2022. PMID: 35254721 Free PMC article.
Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates.
Rodríguez-Bocanegra E, Wozar F, Seitz IP, Reichel FFL, Ochakovski A, Bucher K, Wilhelm B, Bartz-Schmidt KU, Peters T, Fischer MD; RD-CURE Consortium. Rodríguez-Bocanegra E, et al. Among authors: fischer md. Transl Vis Sci Technol. 2021 May 3;10(6):15. doi: 10.1167/tvst.10.6.15. Transl Vis Sci Technol. 2021. PMID: 34111260 Free PMC article.
[Editorial].
Fischer MD, Priglinger C. Fischer MD, et al. Klin Monbl Augenheilkd. 2021 Mar;238(3):247-248. doi: 10.1055/a-1350-7233. Epub 2021 Mar 30. Klin Monbl Augenheilkd. 2021. PMID: 33784787 German. No abstract available.
Surgical Aspects in Gene Therapy for Inherited Retinal Diseases.
Fischer MD, Bartz-Schmidt KU, Dimopoulos S, Herrmann P, Gerhardt M, Holz FG, Priglinger S. Fischer MD, et al. Klin Monbl Augenheilkd. 2021 Mar;238(3):267-271. doi: 10.1055/a-1315-1331. Epub 2021 Feb 22. Klin Monbl Augenheilkd. 2021. PMID: 33618387 English, German.
Spatial and temporal resolution of the photoreceptors rescue dynamics after treatment with voretigene neparvovec.
Stingl K, Kempf M, Bartz-Schmidt KU, Dimopoulos S, Reichel F, Jung R, Kelbsch C, Kohl S, Kortüm FC, Nasser F, Peters T, Wilhelm B, Wissinger B, Wozar F, Zrenner E, Fischer MD, Stingl K. Stingl K, et al. Among authors: fischer md. Br J Ophthalmol. 2022 Jun;106(6):831-838. doi: 10.1136/bjophthalmol-2020-318286. Epub 2021 Jan 20. Br J Ophthalmol. 2022. PMID: 33472769 Free PMC article.
Clinical Phenotype and Course of PDE6A-Associated Retinitis Pigmentosa Disease, Characterized in Preparation for a Gene Supplementation Trial.
Kuehlewein L, Zobor D, Andreasson SO, Ayuso C, Banfi S, Bocquet B, Bernd AS, Biskup S, Boon CJF, Downes SM, Fischer MD, Holz FG, Kellner U, Leroy BP, Meunier I, Nasser F, Rosenberg T, Rudolph G, Stingl K, Thiadens AAHJ, Wilhelm B, Wissinger B, Zrenner E, Kohl S, Weisschuh N; RD-CURE Consortium. Kuehlewein L, et al. Among authors: fischer md. JAMA Ophthalmol. 2020 Dec 1;138(12):1241-1250. doi: 10.1001/jamaophthalmol.2020.4206. JAMA Ophthalmol. 2020. PMID: 33057649 Free PMC article.
Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial.
Fischer MD, Michalakis S, Wilhelm B, Zobor D, Muehlfriedel R, Kohl S, Weisschuh N, Ochakovski GA, Klein R, Schoen C, Sothilingam V, Garcia-Garrido M, Kuehlewein L, Kahle N, Werner A, Dauletbekov D, Paquet-Durand F, Tsang S, Martus P, Peters T, Seeliger M, Bartz-Schmidt KU, Ueffing M, Zrenner E, Biel M, Wissinger B. Fischer MD, et al. JAMA Ophthalmol. 2020 Jun 1;138(6):643-651. doi: 10.1001/jamaophthalmol.2020.1032. JAMA Ophthalmol. 2020. PMID: 32352493 Free PMC article. Clinical Trial.
Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR.
Cehajic-Kapetanovic J, Xue K, Martinez-Fernandez de la Camara C, Nanda A, Davies A, Wood LJ, Salvetti AP, Fischer MD, Aylward JW, Barnard AR, Jolly JK, Luo E, Lujan BJ, Ong T, Girach A, Black GCM, Gregori NZ, Davis JL, Rosa PR, Lotery AJ, Lam BL, Stanga PE, MacLaren RE. Cehajic-Kapetanovic J, et al. Among authors: fischer md. Nat Med. 2020 Mar;26(3):354-359. doi: 10.1038/s41591-020-0763-1. Epub 2020 Feb 24. Nat Med. 2020. PMID: 32094925 Free PMC article. Clinical Trial.
Innate Immune Response Following AAV Administration.
Dauletbekov DL, Pfromm JK, Fritz AK, Fischer MD. Dauletbekov DL, et al. Among authors: fischer md. Adv Exp Med Biol. 2019;1185:165-168. doi: 10.1007/978-3-030-27378-1_27. Adv Exp Med Biol. 2019. PMID: 31884606 Review.
Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia: A Randomized Clinical Trial.
Fischer MD, Ochakovski GA, Beier B, Seitz IP, Vaheb Y, Kortuem C, Reichel FFL, Kuehlewein L, Kahle NA, Peters T, Girach A, Zrenner E, Ueffing M, MacLaren RE, Bartz-Schmidt KU, Wilhelm B. Fischer MD, et al. JAMA Ophthalmol. 2019 Nov 1;137(11):1247-1254. doi: 10.1001/jamaophthalmol.2019.3278. JAMA Ophthalmol. 2019. PMID: 31465092 Free PMC article.
[The Natural History of Choroideraemia].
Seitz IP, Fischer MD. Seitz IP, et al. Among authors: fischer md. Klin Monbl Augenheilkd. 2019 Mar;236(3):236-243. doi: 10.1055/a-0841-3417. Epub 2019 Mar 21. Klin Monbl Augenheilkd. 2019. PMID: 30897643 Review. German.
Decreased contrast sensitivity at high altitude.
Gekeler K, Schatz A, Fischer MD, Schommer K, Boden K, Bartz-Schmidt KU, Gekeler F, Willmann G. Gekeler K, et al. Among authors: fischer md. Br J Ophthalmol. 2019 Dec;103(12):1815-1819. doi: 10.1136/bjophthalmol-2018-313260. Epub 2019 Feb 15. Br J Ophthalmol. 2019. PMID: 30770358
Phenotyping of Mouse Models with OCT.
Ochakovski GA, Fischer MD. Ochakovski GA, et al. Among authors: fischer md. Methods Mol Biol. 2019;1834:285-291. doi: 10.1007/978-1-4939-8669-9_18. Methods Mol Biol. 2019. PMID: 30324450
CHANGES IN RETINAL SENSITIVITY AFTER GENE THERAPY IN CHOROIDEREMIA.
Fischer MD, Ochakovski GA, Beier B, Seitz IP, Vaheb Y, Kortuem C, Reichel FFL, Kuehlewein L, Kahle NA, Peters T, Girach A, Zrenner E, Ueffing M, MacLaren RE, Bartz-Schmidt K, Wilhelm B. Fischer MD, et al. Retina. 2020 Jan;40(1):160-168. doi: 10.1097/IAE.0000000000002360. Retina. 2020. PMID: 30308560 Clinical Trial.
Macular spatial distribution of preserved autofluorescence in patients with choroideremia.
Hariri AH, Ip MS, Girach A, Lam BL, Fischer MD, Sankila EM, Pennesi ME, Holz FG, Maclaren RE, Birch DG, Hoyng CB, MacDonald IM, Black GC, Tsang SH, Bressler NM, Stepien KE, Larsen M, Gorin MB, Meunier I, Webster AR, Sadda S; For Natural History of the Progression of Choroideremia (NIGHT) Study Group. Hariri AH, et al. Among authors: fischer md. Br J Ophthalmol. 2019 Jul;103(7):933-937. doi: 10.1136/bjophthalmol-2018-312620. Epub 2018 Oct 8. Br J Ophthalmol. 2019. PMID: 30297337 Free PMC article.
Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial.
Kahle NA, Peters T, Zobor D, Kuehlewein L, Kohl S, Zhour A, Werner A, Seitz IP, Sothilingam V, Michalakis S, Biel M, Ueffing M, Zrenner E, Bartz-Schmidt KU, Fischer MD, Wilhelm BJC. Kahle NA, et al. Among authors: fischer md. Hum Gene Ther Clin Dev. 2018 Sep;29(3):121-131. doi: 10.1089/humc.2018.088. Hum Gene Ther Clin Dev. 2018. PMID: 30187779
Gene therapy for the treatment of X-linked retinitis pigmentosa.
Martinez-Fernandez De La Camara C, Nanda A, Salvetti AP, Fischer MD, MacLaren RE. Martinez-Fernandez De La Camara C, et al. Among authors: fischer md. Expert Opin Orphan Drugs. 2018 Feb 27;6(3):167-177. doi: 10.1080/21678707.2018.1444476. Expert Opin Orphan Drugs. 2018. PMID: 30057863 Free PMC article.
Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.
Seitz IP, Michalakis S, Wilhelm B, Reichel FF, Ochakovski GA, Zrenner E, Ueffing M, Biel M, Wissinger B, Bartz-Schmidt KU, Peters T, Fischer MD; RD-CURE Consortium. Seitz IP, et al. Among authors: fischer md. Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5792-5801. doi: 10.1167/iovs.17-22473. Invest Ophthalmol Vis Sci. 2017. PMID: 29117317
AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.
Reichel FF, Dauletbekov DL, Klein R, Peters T, Ochakovski GA, Seitz IP, Wilhelm B, Ueffing M, Biel M, Wissinger B, Michalakis S, Bartz-Schmidt KU, Fischer MD; RD-CURE Consortium. Reichel FF, et al. Among authors: fischer md. Mol Ther. 2017 Dec 6;25(12):2648-2660. doi: 10.1016/j.ymthe.2017.08.018. Epub 2017 Aug 31. Mol Ther. 2017. PMID: 28970046 Free PMC article.
High Symmetry of Visual Acuity and Visual Fields in RPGR-Linked Retinitis Pigmentosa.
Bellingrath JS, Ochakovski GA, Seitz IP, Kohl S, Zrenner E, Hanig N, Prokisch H, Weber BH, Downes SM, Ramsden S, MacLaren RE, Fischer MD. Bellingrath JS, et al. Among authors: fischer md. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4457-4466. doi: 10.1167/iovs.17-22077. Invest Ophthalmol Vis Sci. 2017. PMID: 28863407
Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved Retinal Pigment Epithelium Area in Eyes With Choroideremia.
Hariri AH, Velaga SB, Girach A, Ip MS, Le PV, Lam BL, Fischer MD, Sankila EM, Pennesi ME, Holz FG, MacLaren RE, Birch DG, Hoyng CB, MacDonald IM, Black GC, Tsang SH, Bressler NM, Larsen M, Gorin MB, Webster AR, Sadda SR; Natural History of the Progression of Choroideremia (NIGHT) Study Group. Hariri AH, et al. Among authors: fischer md. Am J Ophthalmol. 2017 Jul;179:110-117. doi: 10.1016/j.ajo.2017.05.002. Epub 2017 May 10. Am J Ophthalmol. 2017. PMID: 28499705
A growth mindset approach to preparing trainees for medical error.
Klein J, Delany C, Fischer MD, Smallwood D, Trumble S. Klein J, et al. Among authors: fischer md. BMJ Qual Saf. 2017 Sep;26(9):771-774. doi: 10.1136/bmjqs-2016-006416. Epub 2017 Apr 11. BMJ Qual Saf. 2017. PMID: 28400404 No abstract available.
Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3-Linked Achromatopsia.
Lisowska J, Lisowski L, Kelbsch C, Maeda F, Richter P, Kohl S, Zobor D, Strasser T, Stingl K, Zrenner E, Peters T, Wilhelm H, Fischer MD, Wilhelm B; RD-CURE Consortium. Lisowska J, et al. Among authors: fischer md. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1274-1282. doi: 10.1167/iovs.16-20505. Invest Ophthalmol Vis Sci. 2017. PMID: 28241315
[Stem Cells for Retina Replacement].
Seitz IP, Achberger K, Liebau S, Fischer MD. Seitz IP, et al. Among authors: fischer md. Klin Monbl Augenheilkd. 2016 Dec;233(12):1350-1356. doi: 10.1055/s-0042-105873. Epub 2016 Aug 1. Klin Monbl Augenheilkd. 2016. PMID: 27479580 Review. German.
A global call for action to include gender in research impact assessment.
Ovseiko PV, Greenhalgh T, Adam P, Grant J, Hinrichs-Krapels S, Graham KE, Valentine PA, Sued O, Boukhris OF, Al Olaqi NM, Al Rahbi IS, Dowd AM, Bice S, Heiden TL, Fischer MD, Dopson S, Norton R, Pollitt A, Wooding S, Balling GV, Jakobsen U, Kuhlmann E, Klinge I, Pololi LH, Jagsi R, Smith HL, Etzkowitz H, Nielsen MW, Carrion C, Solans-Domènech M, Vizcaino E, Naing L, Cheok QH, Eckelmann B, Simuyemba MC, Msiska T, Declich G, Edmunds LD, Kiparoglou V, Buchan AM, Williamson C, Lord GM, Channon KM, Surender R, Buchan AM. Ovseiko PV, et al. Among authors: fischer md. Health Res Policy Syst. 2016 Jul 19;14(1):50. doi: 10.1186/s12961-016-0126-z. Health Res Policy Syst. 2016. PMID: 27432056 Free PMC article.
On Retinal Gene Therapy.
Fischer MD. Fischer MD. Ophthalmologica. 2016;236(1):1-7. doi: 10.1159/000445782. Epub 2016 Apr 28. Ophthalmologica. 2016. PMID: 27119148 Free article.
[Stem cell therapy for retinal diseases].
Balmer J, Stanzel BV, Fischer MD. Balmer J, et al. Among authors: fischer md. Ophthalmologe. 2015 Sep;112(9):728-37. doi: 10.1007/s00347-015-0119-2. Ophthalmologe. 2015. PMID: 26271739 German.
In vivo biocompatibility of a new cyanine dye for ILM peeling.
Thaler S, Haritoglou C, Schuettauf F, Choragiewicz T, May CA, Gekeler F, Fischer MD, Langhals H, Schatz A. Thaler S, et al. Among authors: fischer md. Eye (Lond). 2015 Mar;29(3):428-35. doi: 10.1038/eye.2014.295. Epub 2014 Dec 19. Eye (Lond). 2015. PMID: 25523205 Free PMC article.
Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes.
Parkinson NJ, Roddis M, Ferneyhough B, Zhang G, Marsden AJ, Maslau S, Sanchez-Pearson Y, Barthlott T, Humphreys IR, Ladell K, Price DA, Ponting CP, Hollander G, Fischer MD. Parkinson NJ, et al. Among authors: fischer md. Genome Res. 2015 Feb;25(2):226-34. doi: 10.1101/gr.179770.114. Epub 2014 Nov 3. Genome Res. 2015. PMID: 25367293 Free PMC article.
Pupillary light reaction during high altitude exposure.
Schultheiss M, Schommer K, Schatz A, Wilhelm B, Peters T, Fischer MD, Zrenner E, Bartz-Schmidt KU, Gekeler F, Willmann G. Schultheiss M, et al. Among authors: fischer md. PLoS One. 2014 Feb 4;9(2):e87889. doi: 10.1371/journal.pone.0087889. eCollection 2014. PLoS One. 2014. PMID: 24503770 Free PMC article.
An official American Thoracic Society workshop report: assessment and palliative management of dyspnea crisis.
Mularski RA, Reinke LF, Carrieri-Kohlman V, Fischer MD, Campbell ML, Rocker G, Schneidman A, Jacobs SS, Arnold R, Benditt JO, Booth S, Byock I, Chan GK, Curtis JR, Donesky D, Hansen-Flaschen J, Heffner J, Klein R, Limberg TM, Manning HL, Morrison RS, Ries AL, Schmidt GA, Selecky PA, Truog RD, Wang AC, White DB; ATS Ad Hoc Committee on Palliative Management of Dyspnea Crisis. Mularski RA, et al. Among authors: fischer md. Ann Am Thorac Soc. 2013 Oct;10(5):S98-106. doi: 10.1513/AnnalsATS.201306-169ST. Ann Am Thorac Soc. 2013. PMID: 24161068 Free article.
Visual cortex organisation in a macaque monkey with macular degeneration.
Shao Y, Keliris GA, Papanikolaou A, Fischer MD, Zobor D, Jägle H, Logothetis NK, Smirnakis SM. Shao Y, et al. Among authors: fischer md. Eur J Neurosci. 2013 Nov;38(10):3456-64. doi: 10.1111/ejn.12349. Epub 2013 Aug 23. Eur J Neurosci. 2013. PMID: 24033706 Free PMC article.
Impact of acute exposure to high altitude on anterior chamber geometry.
Willmann G, Schatz A, Zhour A, Schommer K, Zrenner E, Bartz-Schmidt KU, Gekeler F, Fischer MD. Willmann G, et al. Among authors: fischer md. Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4241-8. doi: 10.1167/iovs.13-12158. Invest Ophthalmol Vis Sci. 2013. PMID: 23737468
Retinal vessel leakage at high altitude.
Willmann G, Fischer MD, Schatz A, Schommer K, Gekeler F. Willmann G, et al. Among authors: fischer md. JAMA. 2013 Jun 5;309(21):2210-2. doi: 10.1001/jama.2013.5550. JAMA. 2013. PMID: 23736726 No abstract available.
Electroretinographic assessment of retinal function at high altitude.
Schatz A, Willmann G, Fischer MD, Schommer K, Messias A, Zrenner E, Bartz-Schmidt KU, Gekeler F. Schatz A, et al. Among authors: fischer md. J Appl Physiol (1985). 2013 Aug 1;115(3):365-72. doi: 10.1152/japplphysiol.00245.2013. Epub 2013 May 30. J Appl Physiol (1985). 2013. PMID: 23722709 Free article.
Successful subretinal delivery and monitoring of MicroBeads in mice.
Fischer MD, Goldmann T, Wallrapp C, Mühlfriedel R, Beck SC, Stern-Schneider G, Ueffing M, Wolfrum U, Seeliger MW. Fischer MD, et al. PLoS One. 2013;8(1):e55173. doi: 10.1371/journal.pone.0055173. Epub 2013 Jan 28. PLoS One. 2013. PMID: 23383096 Free PMC article.
Phenotyping of mouse models with OCT.
Fischer MD, Zhour A, Kernstock CJ. Fischer MD, et al. Methods Mol Biol. 2013;935:79-85. doi: 10.1007/978-1-62703-080-9_5. Methods Mol Biol. 2013. PMID: 23150361
Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia.
Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Schmidt J, Zong X, Gollisch T, Biel M, Seeliger MW. Michalakis S, et al. Among authors: fischer md. Adv Exp Med Biol. 2012;723:183-9. doi: 10.1007/978-1-4614-0631-0_25. Adv Exp Med Biol. 2012. PMID: 22183332 No abstract available.
Retinal nerve fiber layer loss in multiple system atrophy.
Fischer MD, Synofzik M, Heidlauf R, Schicks J, Srulijes K, Kernstock C, Berg D, Schöls L, Schiefer U. Fischer MD, et al. Mov Disord. 2011 Apr;26(5):914-6. doi: 10.1002/mds.23523. Epub 2011 Mar 21. Mov Disord. 2011. PMID: 21425333 No abstract available.
A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.
Paquet-Durand F, Beck S, Michalakis S, Goldmann T, Huber G, Mühlfriedel R, Trifunović D, Fischer MD, Fahl E, Duetsch G, Becirovic E, Wolfrum U, van Veen T, Biel M, Tanimoto N, Seeliger MW. Paquet-Durand F, et al. Among authors: fischer md. Hum Mol Genet. 2011 Mar 1;20(5):941-7. doi: 10.1093/hmg/ddq539. Epub 2010 Dec 10. Hum Mol Genet. 2011. PMID: 21149284
Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function.
Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Paquet-Durand F, Zong X, Gollisch T, Biel M, Seeliger MW. Michalakis S, et al. Among authors: fischer md. Mol Ther. 2010 Dec;18(12):2057-63. doi: 10.1038/mt.2010.149. Epub 2010 Jul 13. Mol Ther. 2010. PMID: 20628362 Free PMC article.
Induction of STAT3-related genes in fast degenerating cone photoreceptors of cpfl1 mice.
Schaeferhoff K, Michalakis S, Tanimoto N, Fischer MD, Becirovic E, Beck SC, Huber G, Rieger N, Riess O, Wissinger B, Biel M, Seeliger MW, Bonin M. Schaeferhoff K, et al. Among authors: fischer md. Cell Mol Life Sci. 2010 Sep;67(18):3173-86. doi: 10.1007/s00018-010-0376-9. Epub 2010 May 14. Cell Mol Life Sci. 2010. PMID: 20467778 Free PMC article.
In vivo assessment of retinal vascular wall dimensions.
Fischer MD, Huber G, Feng Y, Tanimoto N, Mühlfriedel R, Beck SC, Tröger E, Kernstock C, Preising MN, Lorenz B, Hammes HP, Seeliger MW. Fischer MD, et al. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5254-9. doi: 10.1167/iovs.09-5139. Epub 2010 May 5. Invest Ophthalmol Vis Sci. 2010. PMID: 20445120
Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model.
Jaissle GB, May CA, van de Pavert SA, Wenzel A, Claes-May E, Giessl A, Szurman P, Wolfrum U, Wijnholds J, Fischer MD, Humphries P, Seeliger MW. Jaissle GB, et al. Among authors: fischer md. Graefes Arch Clin Exp Ophthalmol. 2010 Aug;248(8):1063-70. doi: 10.1007/s00417-009-1253-9. Epub 2009 Dec 12. Graefes Arch Clin Exp Ophthalmol. 2010. PMID: 20012642
In vivo analysis of cone survival in mice.
Beck SC, Schaeferhoff K, Michalakis S, Fischer MD, Huber G, Rieger N, Riess O, Wissinger B, Biel M, Bonin M, Seeliger MW, Tanimoto N. Beck SC, et al. Among authors: fischer md. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):493-7. doi: 10.1167/iovs.09-4003. Epub 2009 Sep 8. Invest Ophthalmol Vis Sci. 2010. PMID: 19737879
Spectral domain optical coherence tomography in mouse models of retinal degeneration.
Huber G, Beck SC, Grimm C, Sahaboglu-Tekgoz A, Paquet-Durand F, Wenzel A, Humphries P, Redmond TM, Seeliger MW, Fischer MD. Huber G, et al. Among authors: fischer md. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5888-95. doi: 10.1167/iovs.09-3724. Epub 2009 Aug 6. Invest Ophthalmol Vis Sci. 2009. PMID: 19661229 Free PMC article.
Heregulin ameliorates the dystrophic phenotype in mdx mice.
Krag TO, Bogdanovich S, Jensen CJ, Fischer MD, Hansen-Schwartz J, Javazon EH, Flake AW, Edvinsson L, Khurana TS. Krag TO, et al. Among authors: fischer md. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13856-60. doi: 10.1073/pnas.0405972101. Epub 2004 Sep 13. Proc Natl Acad Sci U S A. 2004. PMID: 15365169 Free PMC article.
Exercise-induced altitude decompression sickness.
Pilmanis AA, Olson RM, Fischer MD, Wiegman JF, Webb JT; New Collective Author. Pilmanis AA, et al. Among authors: fischer md. Aviat Space Environ Med. 1999 Jan;70(1):22-9. Aviat Space Environ Med. 1999. PMID: 9895017
Rhabdomyolysis and renal failure.
Fischer MD, Williams HE. Fischer MD, et al. Ann Intern Med. 1976 Oct;85(4):537. doi: 10.7326/0003-4819-85-4-537_1. Ann Intern Med. 1976. PMID: 970786 No abstract available.