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The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.
Fischer U, Huber J, Boelens WC, Mattaj IW, Lührmann R. Fischer U, et al. Cell. 1995 Aug 11;82(3):475-83. doi: 10.1016/0092-8674(95)90436-0. Cell. 1995. PMID: 7543368
BSA-R did not affect the export of mRNA, tRNA, or ribosomal subunits, but did inhibit export of 5S rRNA and spliceosomal U snRNAs. ...
BSA-R did not affect the export of mRNA, tRNA, or ribosomal subunits, but did inhibit export of 5S rRNA and spliceosomal U snRNAs. .. …
The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis.
Fischer U, Liu Q, Dreyfuss G. Fischer U, et al. Cell. 1997 Sep 19;90(6):1023-9. doi: 10.1016/s0092-8674(00)80368-2. Cell. 1997. PMID: 9323130
Signal-mediated nuclear export pathways of proteins and RNAs.
Fischer U, Michael WM, Lührmann R, Dreyfuss G. Fischer U, et al. Trends Cell Biol. 1996 Aug;6(8):290-3. doi: 10.1016/0962-8924(96)20030-3. Trends Cell Biol. 1996. PMID: 15157436
Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.
Fridell RA, Fischer U, Lührmann R, Meyer BE, Meinkoth JL, Malim MH, Cullen BR. Fridell RA, et al. Among authors: fischer u. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2936-40. doi: 10.1073/pnas.93.7.2936. Proc Natl Acad Sci U S A. 1996. PMID: 8610146 Free PMC article.
A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export.
Izaurralde E, Jarmolowski A, Beisel C, Mattaj IW, Dreyfuss G, Fischer U. Izaurralde E, et al. Among authors: fischer u. J Cell Biol. 1997 Apr 7;137(1):27-35. doi: 10.1083/jcb.137.1.27. J Cell Biol. 1997. PMID: 9105034 Free PMC article.
Saturating levels of M9 have, however, no effect on the import of either U snRNPs or proteins carrying a classical basic NLS. ...
Saturating levels of M9 have, however, no effect on the import of either U snRNPs or proteins carrying a classical basic NLS. ...
Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.
Fischer U, Meyer S, Teufel M, Heckel C, Lührmann R, Rautmann G. Fischer U, et al. EMBO J. 1994 Sep 1;13(17):4105-12. EMBO J. 1994. PMID: 8076606 Free PMC article.
Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.
Fischer U, Pollard VW, Lührmann R, Teufel M, Michael MW, Dreyfuss G, Malim MH. Fischer U, et al. Nucleic Acids Res. 1999 Nov 1;27(21):4128-34. doi: 10.1093/nar/27.21.4128. Nucleic Acids Res. 1999. PMID: 10518602 Free PMC article.
A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA.
van Zee K, Dickmanns A, Fischer U, Lührmann R, Fanning E. van Zee K, et al. Among authors: fischer u. J Cell Biol. 1993 Apr;121(2):229-40. doi: 10.1083/jcb.121.2.229. J Cell Biol. 1993. PMID: 8468344 Free PMC article.
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