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187 results
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M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.
Glantschnig H, Fisher JE, Wesolowski G, Rodan GA, Reszka AA. Glantschnig H, et al. Among authors: fisher je. Cell Death Differ. 2003 Oct;10(10):1165-77. doi: 10.1038/sj.cdd.4401285. Cell Death Differ. 2003. PMID: 14502240
Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins.
Luegmayr E, Glantschnig H, Wesolowski GA, Gentile MA, Fisher JE, Rodan GA, Reszka AA. Luegmayr E, et al. Among authors: fisher je. Cell Death Differ. 2004 Jul;11 Suppl 1:S108-18. doi: 10.1038/sj.cdd.4401399. Cell Death Differ. 2004. PMID: 15017384
In vivo effects of bisphosphonates on the osteoclast mevalonate pathway.
Fisher JE, Rodan GA, Reszka AA. Fisher JE, et al. Endocrinology. 2000 Dec;141(12):4793-6. doi: 10.1210/endo.141.12.7921. Endocrinology. 2000. PMID: 11108295
Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist.
Duggan ME, Duong LT, Fisher JE, Hamill TG, Hoffman WF, Huff JR, Ihle NC, Leu CT, Nagy RM, Perkins JJ, Rodan SB, Wesolowski G, Whitman DB, Zartman AE, Rodan GA, Hartman GD. Duggan ME, et al. Among authors: fisher je. J Med Chem. 2000 Oct 5;43(20):3736-45. doi: 10.1021/jm000133v. J Med Chem. 2000. PMID: 11020288
The integrin ligand echistatin prevents bone loss in ovariectomized mice and rats.
Yamamoto M, Fisher JE, Gentile M, Seedor JG, Leu CT, Rodan SB, Rodan GA. Yamamoto M, et al. Among authors: fisher je. Endocrinology. 1998 Mar;139(3):1411-9. doi: 10.1210/endo.139.3.5831. Endocrinology. 1998. PMID: 9492078
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA, Reszka AA. Fisher JE, et al. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8. doi: 10.1073/pnas.96.1.133. Proc Natl Acad Sci U S A. 1999. PMID: 9874784 Free PMC article.
Inhibition of osteoclastic bone resorption in vivo by echistatin, an "arginyl-glycyl-aspartyl" (RGD)-containing protein.
Fisher JE, Caulfield MP, Sato M, Quartuccio HA, Gould RJ, Garsky VM, Rodan GA, Rosenblatt M. Fisher JE, et al. Endocrinology. 1993 Mar;132(3):1411-3. doi: 10.1210/endo.132.3.8440195. Endocrinology. 1993. PMID: 8440195
Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.
Lipfert L, Fisher JE, Wei N, Scafonas A, Su Q, Yudkovitz J, Chen F, Warrier S, Birzin ET, Kim S, Chen HY, Tan Q, Schmidt A, Dininno F, Rohrer SP, Hammond ML, Rodan GA, Freedman LP, Reszka AA. Lipfert L, et al. Among authors: fisher je. Mol Endocrinol. 2006 Mar;20(3):516-33. doi: 10.1210/me.2005-0190. Epub 2005 Oct 13. Mol Endocrinol. 2006. PMID: 16223974
Nonpeptide alphavbeta3 antagonists. 8. In vitro and in vivo evaluation of a potent alphavbeta3 antagonist for the prevention and treatment of osteoporosis.
Hutchinson JH, Halczenko W, Brashear KM, Breslin MJ, Coleman PJ, Duong LT, Fernandez-Metzler C, Gentile MA, Fisher JE, Hartman GD, Huff JR, Kimmel DB, Leu CT, Meissner RS, Merkle K, Nagy R, Pennypacker B, Perkins JJ, Prueksaritanont T, Rodan GA, Varga SL, Wesolowski GA, Zartman AE, Rodan SB, Duggan ME. Hutchinson JH, et al. Among authors: fisher je. J Med Chem. 2003 Oct 23;46(22):4790-8. doi: 10.1021/jm030306r. J Med Chem. 2003. PMID: 14561098
Parathyroid hormone-related protein (PTHrP): studies with synthetic peptides indicate that parathyroid hormone and PTHrP interact with the same receptor.
Caulfield MP, McKee RL, Goldman ME, Thiede MA, Thompson DD, Fisher JE, Levy JJ, Seedor JG, Horiuchi N, Clemens TL, et al. Caulfield MP, et al. Among authors: fisher je. Int J Rad Appl Instrum B. 1990;17(7):633-7. doi: 10.1016/0883-2897(90)90076-d. Int J Rad Appl Instrum B. 1990. PMID: 2175735 Review. No abstract available.
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