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Targeted protein degradation and the enzymology of degraders.
Fisher SL, Phillips AJ. Fisher SL, et al. Curr Opin Chem Biol. 2018 Jun;44:47-55. doi: 10.1016/j.cbpa.2018.05.004. Epub 2018 Jun 7. Curr Opin Chem Biol. 2018. PMID: 29885948 Review.
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT. Wellington S, et al. Among authors: fisher sl. Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3. Nat Chem Biol. 2017. PMID: 28671682 Free PMC article.
A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy.
Daryaee F, Zhang Z, Gogarty KR, Li Y, Merino J, Fisher SL, Tonge PJ. Daryaee F, et al. Among authors: fisher sl. Chem Sci. 2017 May 1;8(5):3434-3443. doi: 10.1039/c6sc03306g. Epub 2017 Mar 14. Chem Sci. 2017. PMID: 28507715 Free PMC article.
Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.
Daryaee F, Chang A, Schiebel J, Lu Y, Zhang Z, Kapilashrami K, Walker SG, Kisker C, Sotriffer CA, Fisher SL, Tonge PJ. Daryaee F, et al. Among authors: fisher sl. Chem Sci. 2016 Sep 1;7(9):5945-5954. doi: 10.1039/C6SC01000H. Epub 2016 May 25. Chem Sci. 2016. PMID: 27547299 Free PMC article.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Wagner FF, Weïwer M, Steinbacher S, Schomburg A, Reinemer P, Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M, Müller P, Jefson MR, Fass DM, Haggarty SJ, Zhang YL, Holson EB. Wagner FF, et al. Among authors: fisher sl. Bioorg Med Chem. 2016 Sep 15;24(18):4008-4015. doi: 10.1016/j.bmc.2016.06.040. Epub 2016 Jun 22. Bioorg Med Chem. 2016. PMID: 27377864
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.
Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M, Walpita D, Mandrup-Poulsen T, Wagner BK, Holson EB. Wagner FF, et al. Among authors: fisher sl. ACS Chem Biol. 2016 Feb 19;11(2):363-74. doi: 10.1021/acschembio.5b00640. Epub 2015 Dec 7. ACS Chem Biol. 2016. PMID: 26640968
Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.
Wagner FF, Zhang YL, Fass DM, Joseph N, Gale JP, Weïwer M, McCarren P, Fisher SL, Kaya T, Zhao WN, Reis SA, Hennig KM, Thomas M, Lemercier BC, Lewis MC, Guan JS, Moyer MP, Scolnick E, Haggarty SJ, Tsai LH, Holson EB. Wagner FF, et al. Among authors: fisher sl. Chem Sci. 2015 Jan 1;6(1):804-815. doi: 10.1039/C4SC02130D. Chem Sci. 2015. PMID: 25642316 Free PMC article.
Conservation of the structure and function of bacterial tryptophan synthases.
Michalska K, Gale J, Joachimiak G, Chang C, Hatzos-Skintges C, Nocek B, Johnston SE, Bigelow L, Bajrami B, Jedrzejczak RP, Wellington S, Hung DT, Nag PP, Fisher SL, Endres M, Joachimiak A. Michalska K, et al. Among authors: fisher sl. IUCrJ. 2019 May 29;6(Pt 4):649-664. doi: 10.1107/S2052252519005955. eCollection 2019 Jul 1. IUCrJ. 2019. PMID: 31316809 Free PMC article.
High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics.
Simard JR, Lee L, Vieux E, Improgo R, Tieu T, Phillips AJ, Fisher SL, Pollock RM, Park E. Simard JR, et al. Among authors: fisher sl. SLAS Discov. 2021 Jan 11:2472555220985049. doi: 10.1177/2472555220985049. Online ahead of print. SLAS Discov. 2021. PMID: 33430712
Activity of Various Essential Oils Against Clinical Dermatophytes of Microsporum and Trichophyton.
Parrish N, Fisher SL, Gartling A, Craig D, Boire N, Khuvis J, Riedel S, Zhang S. Parrish N, et al. Among authors: fisher sl. Front Cell Infect Microbiol. 2020 Oct 16;10:545913. doi: 10.3389/fcimb.2020.545913. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 33178620 Free PMC article.
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