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Mechanisms of photoaging and chronological skin aging.
Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ. Fisher GJ, et al. Arch Dermatol. 2002 Nov;138(11):1462-70. doi: 10.1001/archderm.138.11.1462. Arch Dermatol. 2002. PMID: 12437452 Review.
The primary environmental factor that causes human skin aging is UV irradiation from the sun. This sun-induced skin aging (photoaging), like chronological aging, is a cumulative process. However, unlike chronological agin …
The primary environmental factor that causes human skin aging is UV irradiation from the sun. This sun-induced skin …
Retinoids suppress cysteine-rich protein 61 (CCN1), a negative regulator of collagen homeostasis, in skin equivalent cultures and aged human skin in vivo.
Quan T, Qin Z, Shao Y, Xu Y, Voorhees JJ, Fisher GJ. Quan T, et al. Exp Dermatol. 2011 Jul;20(7):572-6. doi: 10.1111/j.1600-0625.2011.01278.x. Epub 2011 Apr 13. Exp Dermatol. 2011. PMID: 21488975 Free PMC article.
CCN1 is elevated in the dermis of both chronologically aged and photoaged human skin in vivo and promotes aberrant collagen homeostasis by down-regulating type I collagen, the major structural protein in skin, and promoting collagen degradation. Vitami …
CCN1 is elevated in the dermis of both chronologically aged and photoaged human skin in vivo and promotes aberrant coll …