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Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation.
Wagner TM, Mullally JE, Fitzpatrick FA. Wagner TM, et al. Among authors: fitzpatrick fa. J Biol Chem. 2006 Feb 3;281(5):2598-604. doi: 10.1074/jbc.M509723200. Epub 2005 Nov 25. J Biol Chem. 2006. PMID: 16311241
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