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Inhibition of C3 with pegcetacoplan results in normalization of hemolysis markers in paroxysmal nocturnal hemoglobinuria.
Wong RSM, Pullon HWH, Amine I, Bogdanovic A, Deschatelets P, Francois CG, Ignatova K, Issaragrisil S, Niparuck P, Numbenjapon T, Roman E, Sathar J, Xu R, Al-Adhami M, Tan L, Tse E, Grossi FV. Wong RSM, et al. Ann Hematol. 2022 Sep;101(9):1971-1986. doi: 10.1007/s00277-022-04903-x. Epub 2022 Jul 22. Ann Hematol. 2022. PMID: 35869170 Free PMC article.
The newly approved complement inhibitor, pegcetacoplan, inhibits C3, upstream of C5, and has the potential to improve control of complement-mediated hemolysis. ...
The newly approved complement inhibitor, pegcetacoplan, inhibits C3, upstream of C5, and has the potential to improve control of comp …
Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination.
Une H, Yamasaki R, Nagata S, Yamaguchi H, Nakamuta Y, Indiasari UC, Cui Y, Shinoda K, Masaki K, Götz M, Kira JI. Une H, et al. J Neuroinflammation. 2021 Jun 5;18(1):126. doi: 10.1186/s12974-021-02176-1. J Neuroinflammation. 2021. PMID: 34090477 Free PMC article.
METHODS: Because glutamate aspartate transporter (GLAST)(+) astroglia are enriched in the brain gray matter, we generated Cx43(fl/fl);GLAST-CreER(T2/+) mice that were brain gray matter astroglia-specific Cx43 conditional knockouts (Cx43 icKO). EAE was induced by imm …
METHODS: Because glutamate aspartate transporter (GLAST)(+) astroglia are enriched in the brain gray matter, we generated Cx43(fl/ …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
Roux-en-Y Gastric Bypass Surgery Has Early Differential Effects on Bile Acids and the Levels of Complement Component 3 and Acylation-Stimulating Protein.
Noel OF, Chu X, Patterson AD, Edwards MA, Still CD, Gerhard GS. Noel OF, et al. Obes Surg. 2021 Feb;31(2):773-780. doi: 10.1007/s11695-020-04993-4. Epub 2020 Sep 28. Obes Surg. 2021. PMID: 32986170
BACKGROUND: Bile acids have been implicated in the mechanism by which Roux-en-Y gastric bypass (RYGB) can induce remission of type 2 diabetes (T2D). ...The median (inter-quartile range/IQR) C3 level was 47.4 (34.5, 65.9) mg/dL before surgery decreasing to 40.9 (13.4 …
BACKGROUND: Bile acids have been implicated in the mechanism by which Roux-en-Y gastric bypass (RYGB) can induce remission of type 2 …
Phenological responses of temperate and boreal trees to warming depend on ambient spring temperatures, leaf habit, and geographic range.
Montgomery RA, Rice KE, Stefanski A, Rich RL, Reich PB. Montgomery RA, et al. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10397-10405. doi: 10.1073/pnas.1917508117. Epub 2020 Apr 27. Proc Natl Acad Sci U S A. 2020. PMID: 32341148 Free PMC article.
What is poorly known is whether and how phenological responses to climate warming will differ from year to year, season to season, habitat to habitat, or species to species. Here, we present 5 y of phenological responses to experimental warming for 10 subboreal tree specie …
What is poorly known is whether and how phenological responses to climate warming will differ from year to year, season to season, habitat t …
Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis.
Zhao Y, Yamasaki R, Yamaguchi H, Nagata S, Une H, Cui Y, Masaki K, Nakamuta Y, Iinuma K, Watanabe M, Matsushita T, Isobe N, Kira JI. Zhao Y, et al. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2160-2169. doi: 10.1073/pnas.1901294117. Epub 2020 Jan 13. Proc Natl Acad Sci U S A. 2020. PMID: 31932428 Free PMC article.
CD3+ T cells more abundantly infiltrated the spinal cord in Cx47 icKO than in Cx47 fl/fl mice throughout the acute to chronic phases. CXCR3-CCR6+CD4+ and IL17+IFNgamma-CD4+ helper T (Th) 17 cells isolated from spinal cord and brain tissues were significantly increas …
CD3+ T cells more abundantly infiltrated the spinal cord in Cx47 icKO than in Cx47 fl/fl mice throughout the acute to chronic …
Influence of the Use of Milk Replacers and pH on the Texture Profiles of Raw and Cooked Meat of Suckling Kids.
Ripoll G, Alcalde MJ, Córdoba MG, Casquete R, Argüello A, Ruiz-Moyano S, Panea B. Ripoll G, et al. Foods. 2019 Nov 19;8(11):589. doi: 10.3390/foods8110589. Foods. 2019. PMID: 31752365 Free PMC article.
The aim of this work was to study the texture profile of fresh and cooked longissimus thoracis et lumborum muscle from suckling kids raised with natural milk or milk replacers. Suckling male kids from eight goat breeds (Florida, FL; Cabra del Guadarrama, GU; Majorera, MA; …
The aim of this work was to study the texture profile of fresh and cooked longissimus thoracis et lumborum muscle from suckling kids raised …
21 results