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Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists.
Depommier C, Vitale RM, Iannotti FA, Silvestri C, Flamand N, Druart C, Everard A, Pelicaen R, Maiter D, Thissen JP, Loumaye A, Hermans MP, Delzenne NM, de Vos WM, Di Marzo V, Cani PD. Depommier C, et al. Among authors: flamand n. Cells. 2021 Jan 19;10(1):185. doi: 10.3390/cells10010185. Cells. 2021. PMID: 33477821 Free PMC article. Clinical Trial.
Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis.
Everard A, Plovier H, Rastelli M, Van Hul M, de Wouters d'Oplinter A, Geurts L, Druart C, Robine S, Delzenne NM, Muccioli GG, de Vos WM, Luquet S, Flamand N, Di Marzo V, Cani PD. Everard A, et al. Among authors: flamand n. Nat Commun. 2019 Jan 28;10(1):457. doi: 10.1038/s41467-018-08051-7. Nat Commun. 2019. PMID: 30692526 Free PMC article.
Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways.
Turcotte C, Dumais É, Archambault AS, Martin C, Blanchet MR, Bissonnette É, Boulet LP, Laviolette M, Di Marzo V, Flamand N. Turcotte C, et al. Among authors: flamand n. J Leukoc Biol. 2019 Dec;106(6):1337-1347. doi: 10.1002/JLB.3A0919-049RRR. Epub 2019 Sep 26. J Leukoc Biol. 2019. PMID: 31556464
Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoyl-glycerol and its congeners in human myeloid leukocytes.
Turcotte C, Archambault AS, Dumais É, Martin C, Blanchet MR, Bissonnette E, Ohashi N, Yamamoto K, Itoh T, Laviolette M, Veilleux A, Boulet LP, Di Marzo V, Flamand N. Turcotte C, et al. Among authors: flamand n. FASEB J. 2020 Mar;34(3):4253-4265. doi: 10.1096/fj.201902916R. Epub 2020 Feb 3. FASEB J. 2020. PMID: 32012340
Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism.
Lefort C, Roumain M, Van Hul M, Rastelli M, Manco R, Leclercq I, Delzenne NM, Marzo VD, Flamand N, Luquet S, Silvestri C, Muccioli GG, Cani PD. Lefort C, et al. Among authors: flamand n. Cells. 2020 May 18;9(5):1247. doi: 10.3390/cells9051247. Cells. 2020. PMID: 32443626 Free PMC article.
Alterations of brain endocannabinoidome signaling in germ-free mice.
Manca C, Shen M, Boubertakh B, Martin C, Flamand N, Silvestri C, Di Marzo V. Manca C, et al. Among authors: flamand n. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec;1865(12):158786. doi: 10.1016/j.bbalip.2020.158786. Epub 2020 Aug 11. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32795503
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