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Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms.
Ferreira H, Flaus A, Owen-Hughes T. Ferreira H, et al. J Mol Biol. 2007 Nov 30;374(3):563-79. doi: 10.1016/j.jmb.2007.09.059. Epub 2007 Sep 26. J Mol Biol. 2007. PMID: 17949749 Free PMC article.
Alteration of chromatin structure by chromatin modifying and remodelling activities is a key stage in the regulation of many nuclear processes. ...These observations illustrate a range of different means by which modifications to histones can influence the action of …
Alteration of chromatin structure by chromatin modifying and remodelling activities is a key stage in the regulation of many nuclear …
Unlocking the nucleosome.
Flaus A, Owen-Hughes T. Flaus A, et al. Science. 2017 Jan 20;355(6322):245-246. doi: 10.1126/science.aam5403. Science. 2017. PMID: 28104852 No abstract available.
Viral proteins as a potential driver of histone depletion in dinoflagellates.
Irwin NAT, Martin BJE, Young BP, Browne MJG, Flaus A, Loewen CJR, Keeling PJ, Howe LJ. Irwin NAT, et al. Among authors: flaus a. Nat Commun. 2018 Apr 18;9(1):1535. doi: 10.1038/s41467-018-03993-4. Nat Commun. 2018. PMID: 29670105 Free PMC article.
Mechanisms for ATP-dependent chromatin remodelling: the means to the end.
Flaus A, Owen-Hughes T. Flaus A, et al. FEBS J. 2011 Oct;278(19):3579-95. doi: 10.1111/j.1742-4658.2011.08281.x. Epub 2011 Sep 8. FEBS J. 2011. PMID: 21810178 Free PMC article. Review.
Recently, structural insights have suggested that the Snf2 ATPase acts as a context-sensitive DNA translocase. This may have arisen as a means to enable efficient access to DNA in the high density of the eukaryotic nucleus. ...
Recently, structural insights have suggested that the Snf2 ATPase acts as a context-sensitive DNA translocase. This may have arisen a …
Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures.
Dürr H, Flaus A, Owen-Hughes T, Hopfner KP. Dürr H, et al. Nucleic Acids Res. 2006;34(15):4160-7. doi: 10.1093/nar/gkl540. Epub 2006 Aug 25. Nucleic Acids Res. 2006. PMID: 16935875 Free PMC article. Review.
Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA-protein structures including chromatin. ...Crystal structures suggest that these enzymes travel along the minor groov …
Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a
Nucleosomes can invade DNA territories occupied by their neighbors.
Engeholm M, de Jager M, Flaus A, Brenk R, van Noort J, Owen-Hughes T. Engeholm M, et al. Nat Struct Mol Biol. 2009 Feb;16(2):151-8. doi: 10.1038/nsmb.1551. Epub 2009 Feb 1. Nat Struct Mol Biol. 2009. PMID: 19182801 Free PMC article.
They are not static entities, but can undergo a number of dynamic transitions, including spontaneous repositioning along DNA. ...We propose a pathway in which adjacent nucleosomes promote DNA unraveling as they approach each other and that this permits their 147-bp …
They are not static entities, but can undergo a number of dynamic transitions, including spontaneous repositioning along DNA. ...We p …
Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability.
Ferreira H, Somers J, Webster R, Flaus A, Owen-Hughes T. Ferreira H, et al. Mol Cell Biol. 2007 Jun;27(11):4037-48. doi: 10.1128/MCB.02229-06. Epub 2007 Mar 26. Mol Cell Biol. 2007. PMID: 17387148 Free PMC article.
This raises the possibility that modifications to histone proteins may provide a means of fine-tuning specific aspects of the dynamic properties of nucleosomes to the context in which they are located....
This raises the possibility that modifications to histone proteins may provide a means of fine-tuning specific aspects of the dynamic …
Identification of multiple distinct Snf2 subfamilies with conserved structural motifs.
Flaus A, Martin DM, Barton GJ, Owen-Hughes T. Flaus A, et al. Nucleic Acids Res. 2006 May 31;34(10):2887-905. doi: 10.1093/nar/gkl295. Print 2006. Nucleic Acids Res. 2006. PMID: 16738128 Free PMC article.
These act to regulate the structure and dynamic properties of chromatin and so influence a broad range of nuclear processes. ...The establishment of a phylogeny for Snf2 proteins provides an opportunity to make informed assignments of function, and the identificatio …
These act to regulate the structure and dynamic properties of chromatin and so influence a broad range of nuclear processes. ...The e …
Nucleosome dynamics.
Stockdale C, Bruno M, Ferreira H, Garcia-Wilson E, Wiechens N, Engeholm M, Flaus A, Owen-Hughes T. Stockdale C, et al. Biochem Soc Symp. 2006;(73):109-19. doi: 10.1042/bss0730109. Biochem Soc Symp. 2006. PMID: 16626292 Review.
The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in …
The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently …
Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes.
Stockdale C, Flaus A, Ferreira H, Owen-Hughes T. Stockdale C, et al. J Biol Chem. 2006 Jun 16;281(24):16279-88. doi: 10.1074/jbc.M600682200. Epub 2006 Apr 10. J Biol Chem. 2006. PMID: 16606615 Free PMC article.
ISWI proteins form the catalytic core of a subset of ATP-dependent chromatin remodeling activities in eukaryotes from yeast to man. ...However, a key difference is that the Isw1a, Isw2, and Chd1 enzymes are unable to move nucleosomes to positions closer than 15 bp f …
ISWI proteins form the catalytic core of a subset of ATP-dependent chromatin remodeling activities in eukaryotes from yeast to man. . …
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