Fleming A - Search Results

1

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC. Williams A, et al. Among authors: fleming a. Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79. Nat Chem Biol. 2008. PMID: 18391949 Free PMC article.

2

High-throughput in vivo screening for bone anabolic compounds with zebrafish.

Fleming A, Sato M, Goldsmith P. Fleming A, et al. J Biomol Screen. 2005 Dec;10(8):823-31. doi: 10.1177/1087057105279952. Epub 2005 Oct 18. J Biomol Screen. 2005. PMID: 16234346

3

Non-associative learning in larval zebrafish.

Best JD, Berghmans S, Hunt JJ, Clarke SC, Fleming A, Goldsmith P, Roach AG. Best JD, et al. Among authors: fleming a. Neuropsychopharmacology. 2008 Apr;33(5):1206-15. doi: 10.1038/sj.npp.1301489. Epub 2007 Jun 20. Neuropsychopharmacology. 2008. PMID: 17581529

4

Zebrafish based assays for the assessment of cardiac, visual and gut function--potential safety screens for early drug discovery.

Berghmans S, Butler P, Goldsmith P, Waldron G, Gardner I, Golder Z, Richards FM, Kimber G, Roach A, Alderton W, Fleming A. Berghmans S, et al. Among authors: fleming a. J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):59-68. doi: 10.1016/j.vascn.2008.05.130. Epub 2008 Jun 8. J Pharmacol Toxicol Methods. 2008. PMID: 18585469

5

Loss of PINK1 function affects development and results in neurodegeneration in zebrafish.

Anichtchik O, Diekmann H, Fleming A, Roach A, Goldsmith P, Rubinsztein DC. Anichtchik O, et al. Among authors: fleming a. J Neurosci. 2008 Aug 13;28(33):8199-207. doi: 10.1523/JNEUROSCI.0979-08.2008. J Neurosci. 2008. PMID: 18701682 Free PMC article.

6

Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish.

Diekmann H, Anichtchik O, Fleming A, Futter M, Goldsmith P, Roach A, Rubinsztein DC. Diekmann H, et al. Among authors: fleming a. J Neurosci. 2009 Feb 4;29(5):1343-9. doi: 10.1523/JNEUROSCI.6039-08.2009. J Neurosci. 2009. PMID: 19193881 Free PMC article.

7

In vivo analysis of gut function and disease changes in a zebrafish larvae model of inflammatory bowel disease: a feasibility study.

Fleming A, Jankowski J, Goldsmith P. Fleming A, et al. Inflamm Bowel Dis. 2010 Jul;16(7):1162-72. doi: 10.1002/ibd.21200. Inflamm Bowel Dis. 2010. PMID: 20128011

8

Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects.

Buckley CE, Marguerie A, Roach AG, Goldsmith P, Fleming A, Alderton WK, Franklin RJ. Buckley CE, et al. Among authors: fleming a. Neuropharmacology. 2010 Sep;59(3):149-59. doi: 10.1016/j.neuropharm.2010.04.014. Epub 2010 May 5. Neuropharmacology. 2010. PMID: 20450924

9

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.

Underwood BR, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, Quick M, Korolchuk VI, Renna M, Sarkar S, García-Arencibia M, O'Kane CJ, Murphy MP, Rubinsztein DC. Underwood BR, et al. Among authors: fleming a. Hum Mol Genet. 2010 Sep 1;19(17):3413-29. doi: 10.1093/hmg/ddq253. Epub 2010 Jun 21. Hum Mol Genet. 2010. PMID: 20566712 Free PMC article.

10

Chemical modulators of autophagy as biological probes and potential therapeutics.

Fleming A, Noda T, Yoshimori T, Rubinsztein DC. Fleming A, et al. Nat Chem Biol. 2011 Jan;7(1):9-17. doi: 10.1038/nchembio.500. Nat Chem Biol. 2011. PMID: 21164513 Review.

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