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Aluminum fluoride inhibition of cabbage phospholipase D by a phosphate-mimicking mechanism.
Li L, Fleming N. Li L, et al. FEBS Lett. 1999 Nov 12;461(1-2):1-5. doi: 10.1016/s0014-5793(99)01414-3. FEBS Lett. 1999. PMID: 10561485
Enzyme kinetic studies confirmed that PLD followed Hill kinetics, characteristic for allosteric enzymes, with an apparent Hill coefficient (n(app)) of 3.8, indicating positive cooperativity among multiple substrate-binding sites and suggesting possible functional oligomeri …
Enzyme kinetic studies confirmed that PLD followed Hill kinetics, characteristic for allosteric enzymes, with an apparent Hill coefficient ( …
Muscarinic regulation of phospholipase D and its role in arachidonic acid release in rat submandibular acinar cells.
Chung HC, Fleming N. Chung HC, et al. Pflugers Arch. 1995 Dec;431(2):161-8. doi: 10.1007/BF00410187. Pflugers Arch. 1995. PMID: 9026775
The cell-permeant Ca2+ chelator 1,2-bis-(O-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester (BAPTA/AM) abolished the thapsigargin-induced activation of PLD and inhibited the responses of PLD to carbachol and TPA by 60%. ...
The cell-permeant Ca2+ chelator 1,2-bis-(O-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl e …
Muscarinic M3 receptors are coupled to two signal transduction pathways in rat submandibular cells.
Laniyonu A, Sliwinski-Lis E, Fleming N. Laniyonu A, et al. Eur J Pharmacol. 1990 Mar 13;188(2-3):171-4. doi: 10.1016/0922-4106(90)90052-y. Eur J Pharmacol. 1990. PMID: 2156713
Carbachol-induced phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis was inhibited by all antagonists with a potency rank order of 4-diphenylacetoxy-N-methyl piperidine methobromide (4-DAMP) = atropine much greater than pirenzepine much greater than AF-DX 116 (P less …
Carbachol-induced phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis was inhibited by all antagonists with a potency rank order of 4-di …
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