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IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression of IL-10 by CD4⁺ T Cells.

Ridley ML, Fleskens V, Roberts CA, Lalnunhlimi S, Alnesf A, O'Byrne AM, Steel KJA, Povoleri GAM, Sumner J, Lavender P, Taams LS. Ridley ML, et al. Among authors: fleskens v. J Immunol. 2020 Jun 1;204(11):2940-2948. doi: 10.4049/jimmunol.1901283. Epub 2020 Apr 22. J Immunol. 2020. PMID: 32321757 Free PMC article.

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Posttranslational modifications of PPAR-gamma: fine-tuning the metabolic master regulator.

van Beekum O, Fleskens V, Kalkhoven E. van Beekum O, et al. Among authors: fleskens v. Obesity (Silver Spring). 2009 Feb;17(2):213-9. doi: 10.1038/oby.2008.473. Obesity (Silver Spring). 2009. PMID: 19169221 Free article. Review. No abstract available.

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Forkhead Box P family members at the crossroad between tolerance and immunity: a balancing act.

Fleskens V, van Boxtel R. Fleskens V, et al. Int Rev Immunol. 2014 Mar;33(2):94-109. doi: 10.3109/08830185.2013.816698. Epub 2013 Jul 25. Int Rev Immunol. 2014. PMID: 23886296 Review.

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Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells.

Fleskens V, Minutti CM, Wu X, Wei P, Pals CEGM, McCrae J, Hemmers S, Groenewold V, Vos HJ, Rudensky A, Pan F, Li H, Zaiss DM, Coffer PJ. Fleskens V, et al. Cell Rep. 2019 Mar 26;26(13):3600-3612.e6. doi: 10.1016/j.celrep.2019.02.087. Cell Rep. 2019. PMID: 30917315 Free PMC article.

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FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.

Fleskens V, Mokry M, van der Leun AM, Huppelschoten S, Pals CE, Peeters J, Coenen S, Cardoso BA, Barata JT, van Loosdregt J, Coffer PJ. Fleskens V, et al. Oncogene. 2016 Aug 4;35(31):4141-8. doi: 10.1038/onc.2015.481. Epub 2015 Dec 21. Oncogene. 2016. PMID: 26686090

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Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation.

Bartels M, Govers AM, Fleskens V, Lourenço AR, Pals CE, Vervoort SJ, van Gent R, Brenkman AB, Bierings MB, Ackerman SJ, van Loosdregt J, Coffer PJ. Bartels M, et al. Among authors: fleskens v. Blood. 2015 Mar 12;125(11):1782-92. doi: 10.1182/blood-2013-12-543850. Epub 2015 Jan 7. Blood. 2015. PMID: 25568349 Free article.

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The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.

Tasdelen I, van Beekum O, Gorbenko O, Fleskens V, van den Broek NJ, Koppen A, Hamers N, Berger R, Coffer PJ, Brenkman AB, Kalkhoven E. Tasdelen I, et al. Among authors: fleskens v. Biochem J. 2013 Apr 1;451(1):45-53. doi: 10.1042/BJ20121113. Biochem J. 2013. PMID: 23320500

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Canonical Wnt signaling negatively modulates regulatory T cell function.

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ. van Loosdregt J, et al. Among authors: fleskens v. Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15. Immunity. 2013. PMID: 23954131 Free article.

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Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation.

Mijnheer G, Lutter L, Mokry M, van der Wal M, Scholman R, Fleskens V, Pandit A, Tao W, Wekking M, Vervoort S, Roberts C, Petrelli A, Peeters JGC, Knijff M, de Roock S, Vastert S, Taams LS, van Loosdregt J, van Wijk F. Mijnheer G, et al. Among authors: fleskens v. Nat Commun. 2021 May 11;12(1):2710. doi: 10.1038/s41467-021-22975-7. Nat Commun. 2021. PMID: 33976194 Free PMC article.

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TNF Blockade Maintains an IL-10⁺ Phenotype in Human Effector CD4⁺ and CD8⁺ T Cells.

Roberts CA, Durham LE, Fleskens V, Evans HG, Taams LS. Roberts CA, et al. Among authors: fleskens v. Front Immunol. 2017 Feb 15;8:157. doi: 10.3389/fimmu.2017.00157. eCollection 2017. Front Immunol. 2017. PMID: 28261215 Free PMC article.

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