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Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers N, Chen M, Choi C, Collis LP, Crouse K, Färnegårdh M, Fennell KF, Fish S, Flick AC, Goos-Nilsson A, Gullberg H, Harris PK, Heasley SE, Hegen M, Hromockyj AE, Hu X, Husman B, Janosik T, Jones P, Kaila N, Kallin E, Kauppi B, Kiefer JR, Knafels J, Koehler K, Kruger L, Kurumbail RG, Kyne RE Jr, Li W, Löfstedt J, Long SA, Menard CA, Mente S, Messing D, Meyers MJ, Napierata L, Nöteberg D, Nuhant P, Pelc MJ, Prinsen MJ, Rhönnstad P, Backström-Rydin E, Sandberg J, Sandström M, Shah F, Sjöberg M, Sundell A, Taylor AP, Thorarensen A, Trujillo JI, Trzupek JD, Unwalla R, Vajdos FF, Weinberg RA, Wood DC, Xing L, Zamaratski E, Zapf CW, Zhao Y, Wilhelmsson A, Berstein G. Schnute ME, et al. Among authors: flick ac. J Med Chem. 2018 Dec 13;61(23):10415-10439. doi: 10.1021/acs.jmedchem.8b00392. Epub 2018 Sep 9. J Med Chem. 2018. PMID: 30130103
Synthetic approaches to the 2012 new drugs.
Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Sakya SM, Flick AC, O'Donnell CJ. Ding HX, et al. Among authors: flick ac. Bioorg Med Chem. 2014 Apr 1;22(7):2005-32. doi: 10.1016/j.bmc.2014.02.017. Epub 2014 Feb 25. Bioorg Med Chem. 2014. PMID: 24629448 Review.
Synthetic approaches to the 2013 new drugs.
Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, Flick AC, O'Donnell CJ. Ding HX, et al. Among authors: flick ac. Bioorg Med Chem. 2015 May 1;23(9):1895-922. doi: 10.1016/j.bmc.2015.02.056. Epub 2015 Mar 6. Bioorg Med Chem. 2015. PMID: 25797159 Review.
Synthetic approaches to the 2014 new drugs.
Flick AC, Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, O'Donnell CJ. Flick AC, et al. Bioorg Med Chem. 2016 May 1;24(9):1937-80. doi: 10.1016/j.bmc.2016.03.004. Epub 2016 Mar 9. Bioorg Med Chem. 2016. PMID: 27020685 Review.
Synthetic Approaches to the New Drugs Approved During 2015.
Flick AC, Ding HX, Leverett CA, Kyne RE Jr, Liu KK, Fink SJ, O'Donnell CJ. Flick AC, et al. J Med Chem. 2017 Aug 10;60(15):6480-6515. doi: 10.1021/acs.jmedchem.7b00010. Epub 2017 May 3. J Med Chem. 2017. PMID: 28421763 Review.
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
Fensome A, Ambler CM, Arnold E, Banker ME, Brown MF, Chrencik J, Clark JD, Dowty ME, Efremov IV, Flick A, Gerstenberger BS, Gopalsamy A, Hayward MM, Hegen M, Hollingshead BD, Jussif J, Knafels JD, Limburg DC, Lin D, Lin TH, Pierce BS, Saiah E, Sharma R, Symanowicz PT, Telliez JB, Trujillo JI, Vajdos FF, Vincent F, Wan ZK, Xing L, Yang X, Yang X, Zhang L. Fensome A, et al. J Med Chem. 2018 Oct 11;61(19):8597-8612. doi: 10.1021/acs.jmedchem.8b00917. Epub 2018 Aug 16. J Med Chem. 2018. PMID: 30113844
31 results