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34 results
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Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.
Flies DB, Sandler BJ, Sznol M, Chen L. Flies DB, et al. Yale J Biol Med. 2011 Dec;84(4):409-21. Yale J Biol Med. 2011. PMID: 22180678 Free PMC article. Review.
Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.
Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, Han X, Archer KA, O'Neill T, Herbst RS, Boto AN, Sanmamed MF, Langermann S, Rimm DL, Chen L. Wang J, et al. Among authors: flies db. Nat Med. 2019 Apr;25(4):656-666. doi: 10.1038/s41591-019-0374-x. Epub 2019 Mar 4. Nat Med. 2019. PMID: 30833750 Free PMC article.
B7-h2 is a costimulatory ligand for CD28 in human.
Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L. Yao S, et al. Immunity. 2011 May 27;34(5):729-40. doi: 10.1016/j.immuni.2011.03.014. Epub 2011 Apr 28. Immunity. 2011. PMID: 21530327 Free PMC article.
Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens.
Flies DB, Higuchi T, Chen L. Flies DB, et al. J Immunol. 2015 Jun 1;194(11):5294-304. doi: 10.4049/jimmunol.1402648. Epub 2015 Apr 27. J Immunol. 2015. PMID: 25917101 Free PMC article.
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Chen L, Flies DB. Chen L, et al. Among authors: flies db. Nat Rev Immunol. 2013 Apr;13(4):227-42. doi: 10.1038/nri3405. Epub 2013 Mar 8. Nat Rev Immunol. 2013. PMID: 23470321 Free PMC article. Review.
Modulation of immune response by B7 family molecules in tumor microenvironments.
Flies DB, Chen L. Flies DB, et al. Immunol Invest. 2006;35(3-4):395-418. doi: 10.1080/08820130600755017. Immunol Invest. 2006. PMID: 16916759 Review.
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, Tamada K, Chen L. Hirano F, et al. Among authors: flies db. Cancer Res. 2005 Feb 1;65(3):1089-96. Cancer Res. 2005. PMID: 15705911
B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.
Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L. Dong H, et al. Among authors: flies db. Immunity. 2004 Mar;20(3):327-36. doi: 10.1016/s1074-7613(04)00050-0. Immunity. 2004. PMID: 15030776
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.
Strome SE, Dong H, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen L. Strome SE, et al. Among authors: flies db. Cancer Res. 2003 Oct 1;63(19):6501-5. Cancer Res. 2003. PMID: 14559843
Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.
Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L. Wang S, et al. Among authors: flies db. J Exp Med. 2003 May 5;197(9):1083-91. doi: 10.1084/jem.20021752. Epub 2003 Apr 28. J Exp Med. 2003. PMID: 12719480 Free PMC article.
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