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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1960 3
1961 4
1962 13
1963 49
1964 67
1965 68
1966 48
1967 62
1968 57
1969 48
1970 55
1971 76
1972 94
1973 81
1974 90
1975 59
1976 54
1977 49
1978 40
1979 37
1980 66
1981 49
1982 45
1983 72
1984 72
1985 105
1986 111
1987 92
1988 95
1989 98
1990 93
1991 92
1992 82
1993 85
1994 65
1995 82
1996 59
1997 66
1998 78
1999 81
2000 80
2001 71
2002 73
2003 74
2004 78
2005 66
2006 70
2007 43
2008 56
2009 44
2010 40
2011 54
2012 51
2013 32
2014 26
2015 24
2016 24
2017 23
2018 37
2019 26
2020 28
2021 31
2022 25
2023 0
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Search Results

3,634 results
Results by year
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Page 1
Fluorinated pyrimidines.
Heidelberger C. Heidelberger C. Prog Nucleic Acid Res Mol Biol. 1965;4:1-50. doi: 10.1016/s0079-6603(08)60783-7. Prog Nucleic Acid Res Mol Biol. 1965. PMID: 4226168 Review. No abstract available.
Floxuridine Oligomers Activated under Hypoxic Environment.
Morihiro K, Ishinabe T, Takatsu M, Osumi H, Osawa T, Okamoto A. Morihiro K, et al. J Am Chem Soc. 2021 Mar 10;143(9):3340-3347. doi: 10.1021/jacs.0c10732. Epub 2021 Mar 1. J Am Chem Soc. 2021. PMID: 33648338
Floxuridine oligomers are anticancer oligonucleotide drugs composed of a number of floxuridine residues. They show enhanced cytotoxicity per floxuridine monomer because the nuclease degradation of floxuridine oligomers directly releases highly active …
Floxuridine oligomers are anticancer oligonucleotide drugs composed of a number of floxuridine residues. They show enhanced cy …
Doxifluridine in advanced colorectal cancer.
Calabresi F, Repetto M. Calabresi F, et al. J Surg Oncol Suppl. 1991;2:124-8. doi: 10.1002/jso.2930480526. J Surg Oncol Suppl. 1991. PMID: 1832539 Review. No abstract available.
DNA-Damage-Response-Targeting Mitochondria-Activated Multifunctional Prodrug Strategy for Self-Defensive Tumor Therapy.
Jangili P, Kong N, Kim JH, Zhou J, Liu H, Zhang X, Tao W, Kim JS. Jangili P, et al. Angew Chem Int Ed Engl. 2022 Apr 11;61(16):e202117075. doi: 10.1002/anie.202117075. Epub 2022 Feb 19. Angew Chem Int Ed Engl. 2022. PMID: 35133703
We report a novel multifunctional construct, M1, designed explicitly to target the DNA damage response in cancer cells. M1 contains both a floxuridine (FUDR) and protein phosphatase 2A (PP2A) inhibitor combined with a GSH-sensitive linker. ...
We report a novel multifunctional construct, M1, designed explicitly to target the DNA damage response in cancer cells. M1 contains both a …
The role of floxuridine in metastatic liver disease.
Power DG, Kemeny NE. Power DG, et al. Mol Cancer Ther. 2009 May;8(5):1015-25. doi: 10.1158/1535-7163.MCT-08-0709. Epub 2009 Apr 21. Mol Cancer Ther. 2009. PMID: 19383854 Review.
Sustained high levels of intratumoral drug are achievable with certain drugs given via the hepatic artery. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hep …
Sustained high levels of intratumoral drug are achievable with certain drugs given via the hepatic artery. Floxuridine (FUDR) is an i …
Evaluation of Floxuridine Oligonucleotide Conjugates Carrying Potential Enhancers of Cellular Uptake.
Aviñó A, Clua A, Bleda MJ, Eritja R, Fàbrega C. Aviñó A, et al. Int J Mol Sci. 2021 May 26;22(11):5678. doi: 10.3390/ijms22115678. Int J Mol Sci. 2021. PMID: 34073599 Free PMC article.
The conjugates showed antiproliferative activity due to their metabolic activation by nuclease degradation generating floxuridine monophosphate. The cytotoxicity and apoptosis assays showed an increase in the anti-cancer activity of the conjugates related to the floxuri …
The conjugates showed antiproliferative activity due to their metabolic activation by nuclease degradation generating floxuridine mon …
A photoactivated prodrug.
Wei Y, Yan Y, Pei D, Gong B. Wei Y, et al. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2419-22. doi: 10.1016/s0960-894x(98)00437-5. Bioorg Med Chem Lett. 1998. PMID: 9873553
Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy.
Zhu L, Yang J, Ma Y, Zhu X, Zhang C. Zhu L, et al. J Am Chem Soc. 2022 Feb 2;144(4):1493-1497. doi: 10.1021/jacs.1c09574. Epub 2022 Jan 24. J Am Chem Soc. 2022. PMID: 35073490
To address this challenge, herein we employ four clinically approved nucleoside analogues, including clofarabine (Clo), ara-guanosine (AraG), gemcitabine (Ge), and floxuridine (FdU), to replace all natural nucleosides in aptamer sequences, generating a series of whole drug …
To address this challenge, herein we employ four clinically approved nucleoside analogues, including clofarabine (Clo), ara-guanosine (AraG) …
3,634 results