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Bacterial multidrug transport through the lens of the major facilitator superfamily.
Fluman N, Bibi E. Fluman N, et al. Biochim Biophys Acta. 2009 May;1794(5):738-47. doi: 10.1016/j.bbapap.2008.11.020. Epub 2008 Dec 7. Biochim Biophys Acta. 2009. PMID: 19103310 Review.
Dissection of mechanistic principles of a secondary multidrug efflux protein.
Fluman N, Ryan CM, Whitelegge JP, Bibi E. Fluman N, et al. Mol Cell. 2012 Sep 14;47(5):777-87. doi: 10.1016/j.molcel.2012.06.018. Epub 2012 Jul 26. Mol Cell. 2012. PMID: 22841484 Free PMC article.
Manipulating the drug/proton antiport stoichiometry of the secondary multidrug transporter MdfA.
Tirosh O, Sigal N, Gelman A, Sahar N, Fluman N, Siemion S, Bibi E. Tirosh O, et al. Among authors: fluman n. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12473-8. doi: 10.1073/pnas.1203632109. Epub 2012 Jul 16. Proc Natl Acad Sci U S A. 2012. PMID: 22802625 Free PMC article.
A promiscuous conformational switch in the secondary multidrug transporter MdfA.
Fluman N, Cohen-Karni D, Weiss T, Bibi E. Fluman N, et al. J Biol Chem. 2009 Nov 20;284(47):32296-304. doi: 10.1074/jbc.M109.050658. Epub 2009 Oct 5. J Biol Chem. 2009. PMID: 19808670 Free PMC article.
The secondary multidrug/proton antiporter MdfA tolerates displacements of an essential negatively charged side chain.
Sigal N, Fluman N, Siemion S, Bibi E. Sigal N, et al. Among authors: fluman n. J Biol Chem. 2009 Mar 13;284(11):6966-71. doi: 10.1074/jbc.M808877200. Epub 2009 Jan 7. J Biol Chem. 2009. PMID: 19129186 Free PMC article.
Stable membrane orientations of small dual-topology membrane proteins.
Fluman N, Tobiasson V, von Heijne G. Fluman N, et al. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7987-7992. doi: 10.1073/pnas.1706905114. Epub 2017 Jul 11. Proc Natl Acad Sci U S A. 2017. PMID: 28698365 Free PMC article.
Dynamic membrane topology in an unassembled membrane protein.
Seurig M, Ek M, von Heijne G, Fluman N. Seurig M, et al. Among authors: fluman n. Nat Chem Biol. 2019 Oct;15(10):945-948. doi: 10.1038/s41589-019-0356-9. Epub 2019 Sep 9. Nat Chem Biol. 2019. PMID: 31501590
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