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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 3
1949 2
1952 1
1954 1
1957 2
1958 12
1959 11
1960 27
1961 26
1962 64
1963 103
1964 179
1965 111
1966 124
1967 166
1968 212
1969 203
1970 219
1971 265
1972 288
1973 241
1974 302
1975 332
1976 328
1977 323
1978 354
1979 410
1980 427
1981 403
1982 496
1983 572
1984 644
1985 684
1986 721
1987 738
1988 837
1989 847
1990 857
1991 876
1992 961
1993 932
1994 1003
1995 1052
1996 1086
1997 1115
1998 1103
1999 1229
2000 1330
2001 1285
2002 1459
2003 1536
2004 1655
2005 1790
2006 1926
2007 1931
2008 2011
2009 2089
2010 2340
2011 2369
2012 2476
2013 2538
2014 2502
2015 2540
2016 2465
2017 2379
2018 2327
2019 2378
2020 2487
2021 2441
2022 2239
2023 1992
2024 2203
2025 546

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68,515 results

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Page 1
Clinical pharmacology of 5-fluorouracil.
Diasio RB, Harris BE. Diasio RB, et al. Clin Pharmacokinet. 1989 Apr;16(4):215-37. doi: 10.2165/00003088-198916040-00002. Clin Pharmacokinet. 1989. PMID: 2656050 Review.
The recent development of clinically useful pharmacodynamic assays provides an attractive alternative to plasma drug concentrations, since these assays allow the detection of active metabolites of 5-fluorouracil in biopsied tumour or normal tissue. 5-Fluorouracil is …
The recent development of clinically useful pharmacodynamic assays provides an attractive alternative to plasma drug concentrations, since t …
5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy.
Valencia-Lazcano AA, Hassan D, Pourmadadi M, Shamsabadipour A, Behzadmehr R, Rahdar A, Medina DI, Díez-Pascual AM. Valencia-Lazcano AA, et al. Eur J Med Chem. 2023 Jan 15;246:114995. doi: 10.1016/j.ejmech.2022.114995. Epub 2022 Dec 1. Eur J Med Chem. 2023. PMID: 36493619 Review.
5-Fluorouracil (5-FU) is amongst the most commonly used antimetabolite chemotherapeutic agents in recent decades. ...
5-Fluorouracil (5-FU) is amongst the most commonly used antimetabolite chemotherapeutic agents in recent decades. ...
5-Fluorouracil-associated cardiotoxicity.
Freeman NJ, Costanza ME. Freeman NJ, et al. Cancer. 1988 Jan 1;61(1):36-45. doi: 10.1002/1097-0142(19880101)61:1<36::aid-cncr2820610108>3.0.co;2-6. Cancer. 1988. PMID: 3275485 Review.
Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying corona …
Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have …
Fluorouracil: biochemistry and pharmacology.
Pinedo HM, Peters GF. Pinedo HM, et al. J Clin Oncol. 1988 Oct;6(10):1653-64. doi: 10.1200/JCO.1988.6.10.1653. J Clin Oncol. 1988. PMID: 3049954 Review.
Fluorouracil (5FU) is still considered the most active antineoplastic agent in the treatment of advanced colorectal cancer. ...
Fluorouracil (5FU) is still considered the most active antineoplastic agent in the treatment of advanced colorectal cancer. ...
Mutual Prodrugs of 5-Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs.
Ciaffaglione V, Modica MN, Pittalà V, Romeo G, Salerno L, Intagliata S. Ciaffaglione V, et al. ChemMedChem. 2021 Dec 6;16(23):3496-3512. doi: 10.1002/cmdc.202100473. Epub 2021 Sep 7. ChemMedChem. 2021. PMID: 34415107 Free PMC article. Review.
Among broad-spectrum chemotherapeutics available for clinical use today, 5-fluorouracil (5-FU) is one of the most representative, also included in the World Health Organization model list of essential medicines. ...
Among broad-spectrum chemotherapeutics available for clinical use today, 5-fluorouracil (5-FU) is one of the most representative, als …
5-fluorouracil.
[No authors listed] [No authors listed] IARC Monogr Eval Carcinog Risk Chem Hum. 1981 May;26:217-35. IARC Monogr Eval Carcinog Risk Chem Hum. 1981. PMID: 6944260 No abstract available.
5-Fluorouracil: mechanisms of resistance and reversal strategies.
Zhang N, Yin Y, Xu SJ, Chen WS. Zhang N, et al. Molecules. 2008 Aug 5;13(8):1551-69. doi: 10.3390/molecules13081551. Molecules. 2008. PMID: 18794772 Free PMC article. Review.
The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identifi …
The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review …
Application of Pharmacometrics of 5-Fluorouracil to Personalized Medicine: A Tool for Predicting Pharmacokinetic-Pharmacodynamic/Toxicodynamic Responses.
Kobuchi S, Ito Y. Kobuchi S, et al. Anticancer Res. 2020 Dec;40(12):6585-6597. doi: 10.21873/anticanres.14683. Epub 2020 Dec 7. Anticancer Res. 2020. PMID: 33288553 Review.
Recently, therapeutic drug monitoring of 5-fluorouracil (5-FU), the key chemotherapeutic drug for colorectal cancer, has been applied in daily clinical practice and has contributed towards improving clinical outcomes. ...
Recently, therapeutic drug monitoring of 5-fluorouracil (5-FU), the key chemotherapeutic drug for colorectal cancer, has been applied …
Chemistry and Anticancer Activity of Hybrid Molecules and Derivatives based on 5-Fluorouracil.
Cardona-G W, Herrera-R A, Castrillón-L W, Ramírez-Malule H. Cardona-G W, et al. Curr Med Chem. 2021;28(27):5551-5601. doi: 10.2174/0929867328666210211164314. Curr Med Chem. 2021. PMID: 33573546 Review.
Among these, the use of therapies based on 5-Fluorouracil (5-FU) has been one of the most efficient, with a broad-spectrum. Due to these circumstances, various modifications of 5-FU have been developed to improve drug delivery and reduce side effects. ...
Among these, the use of therapies based on 5-Fluorouracil (5-FU) has been one of the most efficient, with a broad-spectrum. Due to th …
68,515 results
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