Flygare JA - Search Results

1

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D. Varfolomeev E, et al. Among authors: flygare ja. Cell. 2007 Nov 16;131(4):669-81. doi: 10.1016/j.cell.2007.10.030. Cell. 2007. PMID: 18022362 Free article.

2

Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).

Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ. Franklin MC, et al. Among authors: flygare ja. Biochemistry. 2003 Jul 15;42(27):8223-31. doi: 10.1021/bi034227t. Biochemistry. 2003. PMID: 12846571

3

A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo.

Olivero AG, Eigenbrot C, Goldsmith R, Robarge K, Artis DR, Flygare J, Rawson T, Sutherlin DP, Kadkhodayan S, Beresini M, Elliott LO, DeGuzman GG, Banner DW, Ultsch M, Marzec U, Hanson SR, Refino C, Bunting S, Kirchhofer D. Olivero AG, et al. J Biol Chem. 2005 Mar 11;280(10):9160-9. doi: 10.1074/jbc.M409068200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632123 Free article.

4

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Zobel K, et al. Among authors: flygare ja. ACS Chem Biol. 2006 Sep 19;1(8):525-33. doi: 10.1021/cb600276q. ACS Chem Biol. 2006. PMID: 17168540

5

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.

Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ. Cohen F, et al. Among authors: flygare ja. J Med Chem. 2009 Mar 26;52(6):1723-30. doi: 10.1021/jm801450c. J Med Chem. 2009. PMID: 19228017

6

Development of novel drugs targeting inhibitors of apoptosis.

Flygare JA, Vucic D. Flygare JA, et al. Future Oncol. 2009 Mar;5(2):141-4. doi: 10.2217/14796694.5.2.141. Future Oncol. 2009. PMID: 19284370 Free article. No abstract available.

7

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, Maurer B, Fedorova AV, Dynek JN, Koehler M, Hymowitz SG, Tsui V, Deshayes K, Fairbrother WJ, Flygare JA, Vucic D. Ndubaku C, et al. Among authors: flygare ja. ACS Chem Biol. 2009 Jul 17;4(7):557-66. doi: 10.1021/cb900083m. ACS Chem Biol. 2009. PMID: 19492850

8

Small-molecule pan-IAP antagonists: a patent review.

Flygare JA, Fairbrother WJ. Flygare JA, et al. Expert Opin Ther Pat. 2010 Feb;20(2):251-67. doi: 10.1517/13543770903567077. Expert Opin Ther Pat. 2010. PMID: 20100005 Review.

9

Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.

Cohen F, Koehler MF, Bergeron P, Elliott LO, Flygare JA, Franklin MC, Gazzard L, Keteltas SF, Lau K, Ly CQ, Tsui V, Fairbrother WJ. Cohen F, et al. Among authors: flygare ja. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2229-33. doi: 10.1016/j.bmcl.2010.02.021. Epub 2010 Feb 8. Bioorg Med Chem Lett. 2010. PMID: 20189383

10

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG, Elliott LO, Feng B, Franklin MC, Reisner SF, Gazzard L, Halladay J, Hymowitz SG, La H, LoRusso P, Maurer B, Murray L, Plise E, Quan C, Stephan JP, Young SG, Tom J, Tsui V, Um J, Varfolomeev E, Vucic D, Wagner AJ, Wallweber HJ, Wang L, Ware J, Wen Z, Wong H, Wong JM, Wong M, Wong S, Yu R, Zobel K, Fairbrother WJ. Flygare JA, et al. J Med Chem. 2012 May 10;55(9):4101-13. doi: 10.1021/jm300060k. Epub 2012 Mar 28. J Med Chem. 2012. PMID: 22413863 Free PMC article.

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