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53 results
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The effect of Fc glycan forms on human IgG2 antibody clearance in humans.
Chen X, Liu YD, Flynn GC. Chen X, et al. Among authors: flynn gc. Glycobiology. 2009 Mar;19(3):240-9. doi: 10.1093/glycob/cwn120. Epub 2008 Oct 30. Glycobiology. 2009. PMID: 18974198
Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics.
Joubert MK, Deshpande M, Yang J, Reynolds H, Bryson C, Fogg M, Baker MP, Herskovitz J, Goletz TJ, Zhou L, Moxness M, Flynn GC, Narhi LO, Jawa V. Joubert MK, et al. Among authors: flynn gc. PLoS One. 2016 Aug 5;11(8):e0159328. doi: 10.1371/journal.pone.0159328. eCollection 2016. PLoS One. 2016. PMID: 27494246 Free PMC article.
Profiling the effects of process changes on residual host cell proteins in biotherapeutics by mass spectrometry.
Schenauer MR, Flynn GC, Goetze AM. Schenauer MR, et al. Among authors: flynn gc. Biotechnol Prog. 2013 Jul-Aug;29(4):951-7. doi: 10.1002/btpr.1748. Epub 2013 May 21. Biotechnol Prog. 2013. PMID: 23696295
Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects.
Hutterer KM, Hong RW, Lull J, Zhao X, Wang T, Pei R, Le ME, Borisov O, Piper R, Liu YD, Petty K, Apostol I, Flynn GC. Hutterer KM, et al. Among authors: flynn gc. MAbs. 2013 Jul-Aug;5(4):608-13. doi: 10.4161/mabs.24725. Epub 2013 Apr 18. MAbs. 2013. PMID: 23751615 Free PMC article.
Effect of high mannose glycan pairing on IgG antibody clearance.
Liu YD, Flynn GC. Liu YD, et al. Among authors: flynn gc. Biologicals. 2016 May;44(3):163-9. doi: 10.1016/j.biologicals.2016.02.003. Epub 2016 Mar 15. Biologicals. 2016. PMID: 26992607
Protected hinge in the immunoglobulin G2-A2 disulfide isoform.
Liu YD, Chou RY, Dillon TM, Poppe L, Spahr C, Shi SD, Flynn GC. Liu YD, et al. Among authors: flynn gc. Protein Sci. 2014 Dec;23(12):1753-64. doi: 10.1002/pro.2557. Epub 2014 Oct 23. Protein Sci. 2014. PMID: 25264323 Free PMC article.
Assessment of naturally occurring covalent and total dimer levels in human IgG1 and IgG2.
Yang J, Goetze AM, Flynn GC. Yang J, et al. Among authors: flynn gc. Mol Immunol. 2014 Mar;58(1):108-15. doi: 10.1016/j.molimm.2013.11.011. Epub 2013 Dec 8. Mol Immunol. 2014. PMID: 24321397
Cysteine racemization on IgG heavy and light chains.
Zhang Q, Flynn GC. Zhang Q, et al. Among authors: flynn gc. J Biol Chem. 2013 Nov 29;288(48):34325-35. doi: 10.1074/jbc.M113.506915. Epub 2013 Oct 18. J Biol Chem. 2013. PMID: 24142697 Free PMC article.
IgG2 disulfide isoform conversion kinetics.
Liu YD, Wang T, Chou R, Chen L, Kannan G, Stevenson R, Goetze AM, Jiang XG, Huang G, Dillon TM, Flynn GC. Liu YD, et al. Among authors: flynn gc. Mol Immunol. 2013 Jun;54(2):217-26. doi: 10.1016/j.molimm.2012.12.005. Epub 2013 Jan 2. Mol Immunol. 2013. PMID: 23291144
Evaluation of protein disulfide conversion in vitro using a continuous flow dialysis system.
Jiang XG, Wang T, Kaltenbrunner O, Chen K, Flynn GC, Huang G. Jiang XG, et al. Among authors: flynn gc. Anal Biochem. 2013 Jan 15;432(2):142-54. doi: 10.1016/j.ab.2012.09.027. Epub 2012 Sep 27. Anal Biochem. 2013. PMID: 23022378
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