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A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination.
Wessler T, Joslyn LR, Borish HJ, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ. Wessler T, et al. Among authors: Flynn JL. PLoS Comput Biol. 2020 May 20;16(5):e1007280. doi: 10.1371/journal.pcbi.1007280. eCollection 2020 May. PLoS Comput Biol. 2020. PMID: 32433646 Free article.
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH 2nd, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J; HCA Lung Biological Network. Electronic address: lung-network@humancellatlas.org; HCA Lung Biological Network. Ziegler CGK, et al. Among authors: Flynn JL. Cell. 2020 Apr 27:S0092-8674(20)30500-6. doi: 10.1016/j.cell.2020.04.035. Online ahead of print. Cell. 2020. PMID: 32413319 Free article.
At the Interface of Microbiology and Immunology.
Flynn JL. Flynn JL. J Immunol. 2020 Mar 15;204(6):1413-1417. doi: 10.4049/jimmunol.2090001. J Immunol. 2020. PMID: 32152209 No abstract available.
Prevention of tuberculosis in macaques after intravenous BCG immunization.
Darrah PA, Zeppa JJ, Maiello P, Hackney JA, Wadsworth MH 2nd, Hughes TK, Pokkali S, Swanson PA 2nd, Grant NL, Rodgers MA, Kamath M, Causgrove CM, Laddy DJ, Bonavia A, Casimiro D, Lin PL, Klein E, White AG, Scanga CA, Shalek AK, Roederer M, Flynn JL, Seder RA. Darrah PA, et al. Among authors: Flynn JL. Nature. 2020 Jan;577(7788):95-102. doi: 10.1038/s41586-019-1817-8. Epub 2020 Jan 1. Nature. 2020. PMID: 31894150 Free PMC article.
IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Mycobacterium tuberculosis Infection.
Wong EA, Evans S, Kraus CR, Engelman KD, Maiello P, Flores WJ, Cadena AM, Klein E, Thomas K, White AG, Causgrove C, Stein B, Tomko J, Mattila JT, Gideon H, Lin PL, Reimann KA, Kirschner DE, Flynn JL. Wong EA, et al. Among authors: Flynn JL. J Immunol. 2020 Feb 1;204(3):644-659. doi: 10.4049/jimmunol.1901211. Epub 2019 Dec 20. J Immunol. 2020. PMID: 31862711
Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques.
Darrah PA, DiFazio RM, Maiello P, Gideon HP, Myers AJ, Rodgers MA, Hackney JA, Lindenstrom T, Evans T, Scanga CA, Prikhodko V, Andersen P, Lin PL, Laddy D, Roederer M, Seder RA, Flynn JL. Darrah PA, et al. Among authors: Flynn JL. NPJ Vaccines. 2019 May 28;4:21. doi: 10.1038/s41541-019-0113-9. eCollection 2019. NPJ Vaccines. 2019. PMID: 31149352 Free PMC article.
Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques.
Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL. Ganchua SKC, et al. Among authors: Flynn JL. PLoS Pathog. 2018 Nov 1;14(11):e1007337. doi: 10.1371/journal.ppat.1007337. eCollection 2018 Nov. PLoS Pathog. 2018. PMID: 30383808 Free PMC article.
The End of the Binary Era: Revisiting the Spectrum of Tuberculosis.
Lin PL, Flynn JL. Lin PL, et al. Among authors: Flynn JL. J Immunol. 2018 Nov 1;201(9):2541-2548. doi: 10.4049/jimmunol.1800993. J Immunol. 2018. PMID: 30348659 Free PMC article. Review.
Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques.
Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL. Cadena AM, et al. Among authors: Flynn JL. PLoS Pathog. 2018 Oct 12;14(10):e1007305. doi: 10.1371/journal.ppat.1007305. eCollection 2018 Oct. PLoS Pathog. 2018. PMID: 30312351 Free PMC article.
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