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Meropenem: effects on human leukocyte functions and interleukin release.
Matera G, Berlinghieri MC, Focà A. Matera G, et al. Int J Antimicrob Agents. 1995 Apr;5(2):129-33. doi: 10.1016/0924-8579(94)00042-s. Int J Antimicrob Agents. 1995. PMID: 18611660
Modifications of the immune response have been reported for a number of antimicrobial agents following both in vivo and in vitro experiments. Present results were obtained from in vitro incubated human polymorphonuclear cells (PMN) and monocytes treated with meropenem, …
Modifications of the immune response have been reported for a number of antimicrobial agents following both in vivo and in vitro expe …
Effects of two magainin peptides on eicosanoid release from rat peritoneal macrophages.
Matera G, Cook JA, Geisel J, Ashton SH, Wise WC, Focá A, Berkowitz BA, Halushka PV. Matera G, et al. Antimicrob Agents Chemother. 1993 Mar;37(3):393-7. doi: 10.1128/aac.37.3.393. Antimicrob Agents Chemother. 1993. PMID: 8460910 Free PMC article.
The lipid A moiety of LPS reacts with dimethylmethylene blue dye, providing a metachromatic assay of LPS. This metachromatic reaction with lipid A was significantly reduced by polymyxin B and M2 at all concentrations. M1 was effective only at the highest M1:l …
The lipid A moiety of LPS reacts with dimethylmethylene blue dye, providing a metachromatic assay of LPS. This metachromatic r …
Cefixime does not affect polymorphonuclear cell and monocyte functions from chronic lymphoid leukemia patients and from healthy donors.
Liberto MC, Berlinghieri MC, Muleo G, Molica S, Focà A. Liberto MC, et al. J Chemother. 1991 Jan;3 Suppl 1:131-5. J Chemother. 1991. PMID: 12041747
We describe the influence of cefixime, a new orally administered cephalosporin, on some polymorphonuclear cell (PMN) and monocyte functions from healthy donors and from patients affected by chronic lymphoid leukemia (CLL)....
We describe the influence of cefixime, a new orally administered cephalosporin, on some polymorphonuclear cell (PMN) and monocyte fun …
Impairment of immunological functions in genetically epilepsy-prone rats.
De Sarro G, Liberto MC, Berlinghieri MC, Focà A, Aragona M, Cavaliere R, Gulletta E. De Sarro G, et al. Gen Pharmacol. 1996 Jun;27(4):643-6. doi: 10.1016/0306-3623(95)02090-x. Gen Pharmacol. 1996. PMID: 8853298
Flow cytometry revealed that GEPR-9s spleens possessed a large percentage of T-helper cells in comparison to normal rats. 3. By using concanavalin A-induced proliferation of GEPR-9s cultured lymphocytes, we have shown increased functional activation. 4. ...
Flow cytometry revealed that GEPR-9s spleens possessed a large percentage of T-helper cells in comparison to normal rats. 3. By using …
Effect of RO 23-9424, cefotaxime and fleroxacin on functions of human polymorphonuclear cells and cytokine production by human monocytes.
Matera G, Berlinghieri MC, Foti F, Barreca GS, Focà A. Matera G, et al. J Antimicrob Chemother. 1996 Nov;38(5):799-807. doi: 10.1093/jac/38.5.799. J Antimicrob Chemother. 1996. PMID: 8961049
The impact of RO 23-9424, a novel dual-action and extended-spectrum antibiotic, was studied on several functions of human polymorphonuclear neutrophils (PMNs). ...RO 23-9424 (200 mg/L) was able to reduce in a dose-dependent way LPS-induced interleukin-1 beta (IL-1 b …
The impact of RO 23-9424, a novel dual-action and extended-spectrum antibiotic, was studied on several functions of human polymorphon …
Activity of cefixime against Helicobacter pylori.
Fera MT, Carbone M, Focà A. Fera MT, et al. Int J Antimicrob Agents. 1993;3(2):105-8. doi: 10.1016/0924-8579(93)90020-6. Int J Antimicrob Agents. 1993. PMID: 18611550
The in vitro activities of cefixime, a new third-generation cephalosporin, and of 18 other antimicrobial agents against 18 strains of Helicobacter pylori were determined. ...Among cephalosporins, cefixime had the highest antibacterial activity, with a MIC for 90% of …
The in vitro activities of cefixime, a new third-generation cephalosporin, and of 18 other antimicrobial agents against 18 strains of …
Inhibition of endotoxin activity by antibiotics.
Focà A, Matera G, Berlinghieri MC. Focà A, et al. J Antimicrob Chemother. 1993 May;31(5):799. doi: 10.1093/jac/31.5.799. J Antimicrob Chemother. 1993. PMID: 8335508 No abstract available.
Mononuclear cell phenotypes in patients with psoriasis.
Chen Z, Foca A, Norton-Koger B, Dobson RL, Rust P, La Via MF. Chen Z, et al. Dermatologica. 1986;172(6):291-7. doi: 10.1159/000249364. Dermatologica. 1986. PMID: 3488236
Mononuclear blood cells from 19 patients with psoriasis were stained with a panel of monoclonal antibodies which detect total T lymphocytes, their helper/inducer and suppressor/cytotoxic subsets and Ia-positive lymphocytes and monocytes. ...Statistical analysis of data sho …
Mononuclear blood cells from 19 patients with psoriasis were stained with a panel of monoclonal antibodies which detect total T lymph …
Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle.
Lahlali T, Berke JM, Vergauwen K, Foca A, Vandyck K, Pauwels F, Zoulim F, Durantel D. Lahlali T, et al. Antimicrob Agents Chemother. 2018 Sep 24;62(10):e00835-18. doi: 10.1128/AAC.00835-18. Print 2018 Oct. Antimicrob Agents Chemother. 2018. PMID: 30012770 Free PMC article.
In addition to these two known effects of CAMs, we observed for the first time that a CAM, here JNJ-827, when added postinfection for a short-term period, significantly reduced hepatitis B e antigen (HBeAg) secretion without affecting the levels of cccDNA amount, tr …
In addition to these two known effects of CAMs, we observed for the first time that a CAM, here JNJ-827, when added postinfection for …
Polo-like-kinase 1 is a proviral host factor for hepatitis B virus replication.
Diab A, Foca A, Fusil F, Lahlali T, Jalaguier P, Amirache F, N'Guyen L, Isorce N, Cosset FL, Zoulim F, Andrisani O, Durantel D. Diab A, et al. Hepatology. 2017 Dec;66(6):1750-1765. doi: 10.1002/hep.29236. Epub 2017 Nov 6. Hepatology. 2017. PMID: 28445592 Free PMC article.
Herein, we identified cellular serine/threonine Polo-like-kinase 1 (PLK1) as a positive effector of HBV replication. The aim of this study was to demonstrate the proviral role of PLK1 in HBV biosynthesis and validate PLK1 inhibition a potential antiviral strategy. . …
Herein, we identified cellular serine/threonine Polo-like-kinase 1 (PLK1) as a positive effector of HBV replication. The aim of this …
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