Search Page

1

Cite

Share

Telomere Dysfunction Activates p53 and Represses HNF4α Expression Leading to Impaired Human Hepatocyte Development and Function.

Munroe M, Niero EL, Fok WC, Vessoni AT, Jeong HC, Brenner KA, Batista LFZ. Munroe M, et al. Among authors: fok wc. Hepatology. 2020 Oct;72(4):1412-1429. doi: 10.1002/hep.31414. Epub 2020 Aug 26. Hepatology. 2020. PMID: 32516515 Free PMC article.

Cite

Share

2

Cite

Share

Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita.

Fok WC, Shukla S, Vessoni AT, Brenner KA, Parker R, Sturgeon CM, Batista LFZ. Fok WC, et al. Blood. 2019 Mar 21;133(12):1308-1312. doi: 10.1182/blood-2018-11-885368. Epub 2019 Feb 6. Blood. 2019. PMID: 30728146 Free PMC article.

Cite

Share

3

Cite

Share

p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita.

Fok WC, Niero ELO, Dege C, Brenner KA, Sturgeon CM, Batista LFZ. Fok WC, et al. Stem Cell Reports. 2017 Aug 8;9(2):409-418. doi: 10.1016/j.stemcr.2017.06.015. Epub 2017 Jul 27. Stem Cell Reports. 2017. PMID: 28757166 Free PMC article.

Cite

Share

4

Cite

Share

Stressed ends: telomere attrition in chronic diseases.

Fok WC, Batista LFZ. Fok WC, et al. Rev Bras Hematol Hemoter. 2017 Apr-Jun;39(2):98-99. doi: 10.1016/j.bjhh.2017.03.004. Epub 2017 Apr 15. Rev Bras Hematol Hemoter. 2017. PMID: 28577663 Free PMC article. No abstract available.

Cite

Share

5

Cite

Share

Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver.

Yu Z, Wang R, Fok WC, Coles A, Salmon AB, Pérez VI. Yu Z, et al. Among authors: fok wc. J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):410-20. doi: 10.1093/gerona/glu053. Epub 2014 Apr 22. J Gerontol A Biol Sci Med Sci. 2015. PMID: 24755936 Free PMC article.

Cite

Share

6

Cite

Share

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.

Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H. Deepa SS, et al. Among authors: fok wc. Aging Cell. 2018 Aug;17(4):e12769. doi: 10.1111/acel.12769. Epub 2018 Apr 25. Aging Cell. 2018. PMID: 29696791 Free PMC article.

Cite

Share

7

Cite

Share

Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice.

Fok WC, Zhang Y, Salmon AB, Bhattacharya A, Gunda R, Jones D, Ward W, Fisher K, Richardson A, Pérez VI. Fok WC, et al. J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):108-16. doi: 10.1093/gerona/gls127. Epub 2012 May 8. J Gerontol A Biol Sci Med Sci. 2013. PMID: 22570137 Free PMC article.

Cite

Share

8

Cite

Share

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A. Fok WC, et al. PLoS One. 2014 Jan 7;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014. PLoS One. 2014. PMID: 24409289 Free PMC article.

Cite

Share

9

Cite

Share

Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation.

Deepa SS, Bhaskaran S, Ranjit R, Qaisar R, Nair BC, Liu Y, Walsh ME, Fok WC, Van Remmen H. Deepa SS, et al. Among authors: fok wc. Free Radic Biol Med. 2016 Feb;91:281-92. doi: 10.1016/j.freeradbiomed.2015.12.021. Epub 2015 Dec 23. Free Radic Biol Med. 2016. PMID: 26721594 Free PMC article.

Cite

Share

10

Cite

Share

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver.

Fok WC, Bokov A, Gelfond J, Yu Z, Zhang Y, Doderer M, Chen Y, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Richardson A, Pérez VI. Fok WC, et al. Aging Cell. 2014 Apr;13(2):311-9. doi: 10.1111/acel.12175. Epub 2013 Dec 5. Aging Cell. 2014. PMID: 24304444 Free PMC article.

Cite

Share