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The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.
Sci Adv. 2018 Jun 20;4(6):eaat1719. doi: 10.1126/sciadv.aat1719. eCollection 2018 Jun.
Sci Adv. 2018.
PMID: 29938225
Free PMC article.
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.
Fok JHL, Ramos-Montoya A, Vazquez-Chantada M, Wijnhoven PWG, Follia V, James N, Farrington PM, Karmokar A, Willis SE, Cairns J, Nikkilä J, Beattie D, Lamont GM, Finlay MRV, Wilson J, Smith A, O'Connor LO, Ling S, Fawell SE, O'Connor MJ, Hollingsworth SJ, Dean E, Goldberg FW, Davies BR, Cadogan EB.
Fok JHL, et al.
Nat Commun. 2019 Nov 7;10(1):5065. doi: 10.1038/s41467-019-12836-9.
Nat Commun. 2019.
PMID: 31699977
Free PMC article.
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Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development.
Gill SJ, Wijnhoven PWG, Fok JHL, Lloyd RL, Cairns J, Armenia J, Nikkilä J, Lau A, Bakkenist CJ, Galbraith SM, Vens C, O'Connor MJ.
Gill SJ, et al. Among authors: fok jhl.
Mol Cancer Ther. 2021 Sep;20(9):1614-1626. doi: 10.1158/1535-7163.MCT-20-0502. Epub 2021 Jun 22.
Mol Cancer Ther. 2021.
PMID: 34158341
Free PMC article.
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HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.
Fok JHL, Hedayat S, Zhang L, Aronson LI, Mirabella F, Pawlyn C, Bright MD, Wardell CP, Keats JJ, De Billy E, Rye CS, Chessum NEA, Jones K, Morgan GJ, Eccles SA, Workman P, Davies FE.
Fok JHL, et al.
Clin Cancer Res. 2018 May 15;24(10):2395-2407. doi: 10.1158/1078-0432.CCR-17-1594. Epub 2018 Feb 1.
Clin Cancer Res. 2018.
PMID: 29391353
Free PMC article.
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A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
Singh D, Deosarkar SP, Cadogan E, Flemington V, Bray A, Zhang J, Reiserer RS, Schaffer DK, Gerken GB, Britt CM, Werner EM, Gibbons FD, Kostrzewski T, Chambers CE, Davies EJ, Montoya AR, Fok JHL, Hughes D, Fabre K, Wagoner MP, Wikswo JP, Scott CW.
Singh D, et al. Among authors: fok jhl.
PLoS Biol. 2022 May 26;20(5):e3001624. doi: 10.1371/journal.pbio.3001624. eCollection 2022 May.
PLoS Biol. 2022.
PMID: 35617197
Free PMC article.
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Heat shock proteins in multiple myeloma.
Zhang L, Fok JH, Davies FE.
Zhang L, et al.
Oncotarget. 2014 Mar 15;5(5):1132-48. doi: 10.18632/oncotarget.1584.
Oncotarget. 2014.
PMID: 24675290
Free PMC article.
Review.
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A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.
Mirabella F, Murison A, Aronson LI, Wardell CP, Thompson AJ, Hanrahan SJ, Fok JH, Pawlyn C, Kaiser MF, Walker BA, Davies FE, Morgan GJ.
Mirabella F, et al.
PLoS One. 2014 Jun 12;9(6):e99493. doi: 10.1371/journal.pone.0099493. eCollection 2014.
PLoS One. 2014.
PMID: 24923560
Free PMC article.
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