Fok WC - Search Results

1

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A. Fok WC, et al. PLoS One. 2014 Jan 7;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014. PLoS One. 2014. PMID: 24409289 Free PMC article.

2

Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice.

Fok WC, Zhang Y, Salmon AB, Bhattacharya A, Gunda R, Jones D, Ward W, Fisher K, Richardson A, Pérez VI. Fok WC, et al. J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):108-16. doi: 10.1093/gerona/gls127. Epub 2012 May 8. J Gerontol A Biol Sci Med Sci. 2013. PMID: 22570137 Free PMC article.

3

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver.

Fok WC, Bokov A, Gelfond J, Yu Z, Zhang Y, Doderer M, Chen Y, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Richardson A, Pérez VI. Fok WC, et al. Aging Cell. 2014 Apr;13(2):311-9. doi: 10.1111/acel.12175. Epub 2013 Dec 5. Aging Cell. 2014. PMID: 24304444 Free PMC article.

4

Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver.

Yu Z, Wang R, Fok WC, Coles A, Salmon AB, Pérez VI. Yu Z, et al. Among authors: fok wc. J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):410-20. doi: 10.1093/gerona/glu053. Epub 2014 Apr 22. J Gerontol A Biol Sci Med Sci. 2015. PMID: 24755936 Free PMC article.

5

Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction.

Fok WC, Livi C, Bokov A, Yu Z, Chen Y, Richardson A, Pérez VI. Fok WC, et al. Mech Ageing Dev. 2014 Sep;140:23-9. doi: 10.1016/j.mad.2014.07.004. Epub 2014 Jul 27. Mech Ageing Dev. 2014. PMID: 25075714 Free PMC article.

6

Gene expression in the liver of female, but not male mice treated with rapamycin resembles changes observed under dietary restriction.

Yu Z, Sunchu B, Fok WC, Alshaikh N, Pérez VI. Yu Z, et al. Among authors: fok wc. Springerplus. 2015 Apr 11;4:174. doi: 10.1186/s40064-015-0909-7. eCollection 2015. Springerplus. 2015. PMID: 26034704 Free PMC article.

7

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.

Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H. Deepa SS, et al. Among authors: fok wc. Aging Cell. 2018 Aug;17(4):e12769. doi: 10.1111/acel.12769. Epub 2018 Apr 25. Aging Cell. 2018. PMID: 29696791 Free PMC article.

8

Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.

Pérez VI, Cortez LA, Lew CM, Rodriguez M, Webb CR, Van Remmen H, Chaudhuri A, Qi W, Lee S, Bokov A, Fok W, Jones D, Richardson A, Yodoi J, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y. Pérez VI, et al. J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1286-99. doi: 10.1093/gerona/glr125. Epub 2011 Aug 26. J Gerontol A Biol Sci Med Sci. 2011. PMID: 21873593 Free PMC article.

9

Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation.

Deepa SS, Bhaskaran S, Ranjit R, Qaisar R, Nair BC, Liu Y, Walsh ME, Fok WC, Van Remmen H. Deepa SS, et al. Among authors: fok wc. Free Radic Biol Med. 2016 Feb;91:281-92. doi: 10.1016/j.freeradbiomed.2015.12.021. Epub 2015 Dec 23. Free Radic Biol Med. 2016. PMID: 26721594 Free PMC article.

10

Telomere Dysfunction Activates p53 and Represses HNF4α Expression Leading to Impaired Human Hepatocyte Development and Function.

Munroe M, Niero EL, Fok WC, Vessoni AT, Jeong HC, Brenner KA, Batista LFZ. Munroe M, et al. Among authors: fok wc. Hepatology. 2020 Oct;72(4):1412-1429. doi: 10.1002/hep.31414. Epub 2020 Aug 26. Hepatology. 2020. PMID: 32516515 Free PMC article.

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