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Agonist potency at P2X7 receptors is modulated by structurally diverse lipids.
Michel AD, Fonfria E. Michel AD, et al. Among authors: fonfria e. Br J Pharmacol. 2007 Oct;152(4):523-37. doi: 10.1038/sj.bjp.0707417. Epub 2007 Aug 13. Br J Pharmacol. 2007. PMID: 17700717 Free PMC article.
Species and response dependent differences in the effects of MAPK inhibitors on P2X(7) receptor function.
Michel AD, Thompson KM, Simon J, Boyfield I, Fonfria E, Humphrey PP. Michel AD, et al. Among authors: fonfria e. Br J Pharmacol. 2006 Dec;149(7):948-57. doi: 10.1038/sj.bjp.0706938. Epub 2006 Oct 9. Br J Pharmacol. 2006. PMID: 17031382 Free PMC article.
Cloning and pharmacological characterization of the dog P2X7 receptor.
Roman S, Cusdin FS, Fonfria E, Goodwin JA, Reeves J, Lappin SC, Chambers L, Walter DS, Clay WC, Michel AD. Roman S, et al. Among authors: fonfria e. Br J Pharmacol. 2009 Nov;158(6):1513-26. doi: 10.1111/j.1476-5381.2009.00425.x. Epub 2009 Oct 8. Br J Pharmacol. 2009. PMID: 19814727 Free PMC article.
Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue.
Fonfria E, Clay WC, Levy DS, Goodwin JA, Roman S, Smith GD, Condreay JP, Michel AD. Fonfria E, et al. Br J Pharmacol. 2008 Feb;153(3):544-56. doi: 10.1038/sj.bjp.0707596. Epub 2007 Nov 26. Br J Pharmacol. 2008. PMID: 18037910 Free PMC article.
TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia.
Fonfria E, Mattei C, Hill K, Brown JT, Randall A, Benham CD, Skaper SD, Campbell CA, Crook B, Murdock PR, Wilson JM, Maurio FP, Owen DE, Tilling PL, McNulty S. Fonfria E, et al. J Recept Signal Transduct Res. 2006;26(3):179-98. doi: 10.1080/10799890600637522. J Recept Signal Transduct Res. 2006. PMID: 16777714
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase.
Fonfria E, Marshall IC, Benham CD, Boyfield I, Brown JD, Hill K, Hughes JP, Skaper SD, McNulty S. Fonfria E, et al. Br J Pharmacol. 2004 Sep;143(1):186-92. doi: 10.1038/sj.bjp.0705914. Epub 2004 Aug 9. Br J Pharmacol. 2004. PMID: 15302683 Free PMC article.
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.
Abberley L, Bebius A, Beswick PJ, Billinton A, Collis KL, Dean DK, Fonfria E, Gleave RJ, Medhurst SJ, Michel AD, Moses AP, Patel S, Roman SA, Scoccitti T, Smith B, Steadman JG, Walter DS. Abberley L, et al. Among authors: fonfria e. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6370-4. doi: 10.1016/j.bmcl.2010.09.101. Epub 2010 Sep 22. Bioorg Med Chem Lett. 2010. PMID: 20934331
Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.
Abdi MH, Beswick PJ, Billinton A, Chambers LJ, Charlton A, Collins SD, Collis KL, Dean DK, Fonfria E, Gleave RJ, Lejeune CL, Livermore DG, Medhurst SJ, Michel AD, Moses AP, Page L, Patel S, Roman SA, Senger S, Slingsby B, Steadman JG, Stevens AJ, Walter DS. Abdi MH, et al. Among authors: fonfria e. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5080-4. doi: 10.1016/j.bmcl.2010.07.033. Epub 2010 Jul 14. Bioorg Med Chem Lett. 2010. PMID: 20673717
Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.
Gleave RJ, Walter DS, Beswick PJ, Fonfria E, Michel AD, Roman SA, Tang SP. Gleave RJ, et al. Among authors: fonfria e. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4951-4. doi: 10.1016/j.bmcl.2010.05.018. Epub 2010 Jun 25. Bioorg Med Chem Lett. 2010. PMID: 20634071
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.
Chambers LJ, Stevens AJ, Moses AP, Michel AD, Walter DS, Davies DJ, Livermore DG, Fonfria E, Demont EH, Vimal M, Theobald PJ, Beswick PJ, Gleave RJ, Roman SA, Senger S. Chambers LJ, et al. Among authors: fonfria e. Bioorg Med Chem Lett. 2010 May 15;20(10):3161-4. doi: 10.1016/j.bmcl.2010.03.096. Epub 2010 Mar 30. Bioorg Med Chem Lett. 2010. PMID: 20399651
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