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1983 1
1996 1
1998 1
2002 1
2013 1
2021 0
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Food-drug interactions.
Schmidt LE, Dalhoff K. Schmidt LE, et al. Drugs. 2002;62(10):1481-502. doi: 10.2165/00003495-200262100-00005. Drugs. 2002. PMID: 12093316 Review.
The majority of clinically relevant food-drug interactions are caused by food-induced changes in the bioavailability of the drug. ...For other drugs, concomitant food intake may result in an increase in drug bioavailability either because …
The majority of clinically relevant food-drug interactions are caused by food-induced changes in the bioavailability of …
Food increases the bioavailability of isotretinoin.
Colburn WA, Gibson DM, Wiens RE, Hanigan JJ. Colburn WA, et al. J Clin Pharmacol. 1983 Nov-Dec;23(11-12):534-9. doi: 10.1002/j.1552-4604.1983.tb01800.x. J Clin Pharmacol. 1983. PMID: 6582073 Clinical Trial.
The relative bioavailability (AUC) of isotretinoin was found to be approximately 1.5 to 2 times greater when the dose was administered 1 hour before, concomitantly with, or 1 hour after a meal than when it was given during a complete fast. In addition, because the C …
The relative bioavailability (AUC) of isotretinoin was found to be approximately 1.5 to 2 times greater when the dose was admi …
Improving bioavailability with a novel isotretinoin formulation (isotretinoin-Lidose).
Tan J, Knezevic S. Tan J, et al. Skin Therapy Lett. 2013 Sep-Oct;18(6):1-3. Skin Therapy Lett. 2013. PMID: 24305729 Free article.
Isotretinoin-Lidose (Epuris), approved by Health Canada in November 2012 and scheduled for commercial release June 2013, is based on novel lipid encapsulation technology (Lidose) to enclose isotretinoin, thereby increasing drug absorption during fasted states
Isotretinoin-Lidose (Epuris), approved by Health Canada in November 2012 and scheduled for commercial release June 2013, is based on
Oral retinoids in the treatment of seborrhoea and acne.
Orfanos CE, Zouboulis CC. Orfanos CE, et al. Dermatology. 1998;196(1):140-7. doi: 10.1159/000017848. Dermatology. 1998. PMID: 9557249
Its bioavailability is approximately 25% and can be increased by food 1.5-2 times; after 30 min, the drug is detectable in the blood and maximal concentrations are reached 2-4 h after oral intake. The major metabolites of isotretinoin in blood are 4-hy …
Its bioavailability is approximately 25% and can be increased by food 1.5-2 times; after 30 min, the drug is detectable …
Pharmacokinetics of retinoids in women after meal consumption or vitamin A supplementation.
Chen C, Mistry G, Jensen B, Heizmann P, Timm U, van Brummelen P, Rakhit AK. Chen C, et al. J Clin Pharmacol. 1996 Sep;36(9):799-808. doi: 10.1002/j.1552-4604.1996.tb04253.x. J Clin Pharmacol. 1996. PMID: 8889900
Linear relationships between dose and maximum concentration (Cmax) and dose and area under the concentration-time curve (AUC) for isotretinoin and 4-oxo-isotretinoin were derived from data from the meal study. For the most bioavailable formulation used in the …
Linear relationships between dose and maximum concentration (Cmax) and dose and area under the concentration-time curve (AUC) for isotret