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Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase.
Giardina SF, Werner DS, Pingle M, Feinberg PB, Foreman KW, Bergstrom DE, Arnold LD, Barany F. Giardina SF, et al. Among authors: foreman kw. J Med Chem. 2020 Mar 26;63(6):3004-3027. doi: 10.1021/acs.jmedchem.9b01689. Epub 2020 Feb 27. J Med Chem. 2020. PMID: 32057241
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.
Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J. Moretto AF, et al. Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. doi: 10.1016/j.bmc.2005.11.005. Epub 2005 Nov 21. Bioorg Med Chem. 2006. PMID: 16303309
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Wilson DP, Wan ZK, Xu WX, Kirincich SJ, Follows BC, Joseph-McCarthy D, Foreman K, Moretto A, Wu J, Zhu M, Binnun E, Zhang YL, Tam M, Erbe DV, Tobin J, Xu X, Leung L, Shilling A, Tam SY, Mansour TS, Lee J. Wilson DP, et al. J Med Chem. 2007 Sep 20;50(19):4681-98. doi: 10.1021/jm0702478. Epub 2007 Aug 17. J Med Chem. 2007. PMID: 17705360
Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR.
Jin M, Gokhale PC, Cooke A, Foreman K, Buck E, May EW, Feng L, Bittner MA, Kadalbajoo M, Landfair D, Siu KW, Stolz KM, Werner DS, Laufer RS, Li AH, Dong H, Steinig AG, Kleinberg A, Yao Y, Pachter JA, Wild R, Mulvihill MJ. Jin M, et al. Among authors: foreman k. ACS Med Chem Lett. 2010 Aug 30;1(9):510-5. doi: 10.1021/ml100178g. eCollection 2010 Dec 9. ACS Med Chem Lett. 2010. PMID: 24900240 Free PMC article.
Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.
Wanner J, Romashko D, Werner DS, May EW, Peng Y, Schulz R, Foreman KW, Russo S, Arnold LD, Pingle M, Bergstrom DE, Barany F, Thomson S. Wanner J, et al. Among authors: foreman kw. PLoS One. 2015 Apr 15;10(4):e0121793. doi: 10.1371/journal.pone.0121793. eCollection 2015. PLoS One. 2015. PMID: 25875098 Free PMC article.
Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase.
Giardina SF, Werner DS, Pingle M, Foreman KW, Bergstrom DE, Arnold LD, Barany F. Giardina SF, et al. Among authors: foreman kw. ACS Med Chem Lett. 2018 Jul 5;9(8):827-831. doi: 10.1021/acsmedchemlett.8b00204. eCollection 2018 Aug 9. ACS Med Chem Lett. 2018. PMID: 30128075 Free PMC article.
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.
Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Kincaid SL, Sukhdeo MN, Sutherland AG, Ding W, Kenny CH, Sabus CL, Liu H, Dushin EG, Moghazeh SL, Labthavikul P, Petersen PJ, Tuckman M, Haney SA, Ruzin AV. Jennings LD, et al. Among authors: foreman kw. Bioorg Med Chem. 2004 Oct 1;12(19):5115-31. doi: 10.1016/j.bmc.2004.07.031. Bioorg Med Chem. 2004. PMID: 15351395
25 results