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New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics.
Gorham RD Jr, Forest DL, Khoury GA, Smadbeck J, Beecher CN, Healy ED, Tamamis P, Archontis G, Larive CK, Floudas CA, Radeke MJ, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: forest dl. J Med Chem. 2015 Jan 22;58(2):814-26. doi: 10.1021/jm501345y. Epub 2014 Dec 29. J Med Chem. 2015. PMID: 25494040 Free PMC article.
Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures.
Gorham RD Jr, Forest DL, Tamamis P, López de Victoria A, Kraszni M, Kieslich CA, Banna CD, Bellows-Peterson ML, Larive CK, Floudas CA, Archontis G, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: forest dl. Exp Eye Res. 2013 Nov;116:96-108. doi: 10.1016/j.exer.2013.07.023. Epub 2013 Aug 15. Exp Eye Res. 2013. PMID: 23954241 Free PMC article.
Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration.
Johnson LV, Forest DL, Banna CD, Radeke CM, Maloney MA, Hu J, Spencer CN, Walker AM, Tsie MS, Bok D, Radeke MJ, Anderson DH. Johnson LV, et al. Among authors: forest dl. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18277-82. doi: 10.1073/pnas.1109703108. Epub 2011 Oct 3. Proc Natl Acad Sci U S A. 2011. PMID: 21969589 Free PMC article.