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Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo.
Formentini L, Moroni F, Chiarugi A. Formentini L, et al. Biochem Pharmacol. 2009 May 15;77(10):1612-20. doi: 10.1016/j.bcp.2009.02.017. Epub 2009 Mar 5. Biochem Pharmacol. 2009. PMID: 19426698
Dexpramipexole improves bioenergetics and outcome in experimental stroke.
Muzzi M, Gerace E, Buonvicino D, Coppi E, Resta F, Formentini L, Zecchi R, Tigli L, Guasti D, Ferri M, Camaioni E, Masi A, Pellegrini-Giampietro DE, Mannaioni G, Bani D, Pugliese AM, Chiarugi A. Muzzi M, et al. Among authors: formentini l. Br J Pharmacol. 2018 Jan;175(2):272-283. doi: 10.1111/bph.13790. Epub 2017 May 12. Br J Pharmacol. 2018. PMID: 28320070 Free PMC article.
Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase.
Moroni F, Cozzi A, Chiarugi A, Formentini L, Camaioni E, Pellegrini-Giampietro DE, Chen Y, Liang S, Zaleska MM, Gonzales C, Wood A, Pellicciari R. Moroni F, et al. Among authors: formentini l. Br J Pharmacol. 2012 Mar;165(5):1487-500. doi: 10.1111/j.1476-5381.2011.01666.x. Br J Pharmacol. 2012. PMID: 21913897 Free PMC article.
Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death.
Formentini L, Arapistas P, Pittelli M, Jacomelli M, Pitozzi V, Menichetti S, Romani A, Giovannelli L, Moroni F, Chiarugi A. Formentini L, et al. Br J Pharmacol. 2008 Dec;155(8):1235-49. doi: 10.1038/bjp.2008.370. Epub 2008 Sep 22. Br J Pharmacol. 2008. PMID: 18806807 Free PMC article.
Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
Moroni F, Formentini L, Gerace E, Camaioni E, Pellegrini-Giampietro DE, Chiarugi A, Pellicciari R. Moroni F, et al. Among authors: formentini l. Br J Pharmacol. 2009 Jul;157(5):854-62. doi: 10.1111/j.1476-5381.2009.00232.x. Epub 2009 May 5. Br J Pharmacol. 2009. PMID: 19422384 Free PMC article.
Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance.
Gerace E, Scartabelli T, Formentini L, Landucci E, Moroni F, Chiarugi A, Pellegrini-Giampietro DE. Gerace E, et al. Among authors: formentini l. Eur J Neurosci. 2012 Jul;36(1):1993-2005. doi: 10.1111/j.1460-9568.2012.08116.x. Epub 2012 May 28. Eur J Neurosci. 2012. PMID: 22639866
Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice.
Cozzi A, Cipriani G, Fossati S, Faraco G, Formentini L, Min W, Cortes U, Wang ZQ, Moroni F, Chiarugi A. Cozzi A, et al. Among authors: formentini l. J Cereb Blood Flow Metab. 2006 May;26(5):684-95. doi: 10.1038/sj.jcbfm.9600222. J Cereb Blood Flow Metab. 2006. PMID: 16177811
Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.
Faraco G, Pancani T, Formentini L, Mascagni P, Fossati G, Leoni F, Moroni F, Chiarugi A. Faraco G, et al. Among authors: formentini l. Mol Pharmacol. 2006 Dec;70(6):1876-84. doi: 10.1124/mol.106.027912. Epub 2006 Aug 31. Mol Pharmacol. 2006. PMID: 16946032
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool.
Pittelli M, Formentini L, Faraco G, Lapucci A, Rapizzi E, Cialdai F, Romano G, Moneti G, Moroni F, Chiarugi A. Pittelli M, et al. Among authors: formentini l. J Biol Chem. 2010 Oct 29;285(44):34106-14. doi: 10.1074/jbc.M110.136739. Epub 2010 Aug 19. J Biol Chem. 2010. PMID: 20724478 Free PMC article.
Glucose deprivation converts poly(ADP-ribose) polymerase-1 hyperactivation into a transient energy-producing process.
Buonvicino D, Formentini L, Cipriani G, Chiarugi A. Buonvicino D, et al. Among authors: formentini l. J Biol Chem. 2013 Dec 20;288(51):36530-7. doi: 10.1074/jbc.M113.506378. Epub 2013 Nov 5. J Biol Chem. 2013. PMID: 24194524 Free PMC article.
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