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Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.
Sánchez-Cenizo L, Formentini L, Aldea M, Ortega AD, García-Huerta P, Sánchez-Aragó M, Cuezva JM. Sánchez-Cenizo L, et al. Among authors: formentini l. J Biol Chem. 2010 Aug 13;285(33):25308-13. doi: 10.1074/jbc.M110.146480. Epub 2010 Jun 9. J Biol Chem. 2010. PMID: 20538613 Free PMC article.
IF1 reprograms energy metabolism and signals the oncogenic phenotype in cancer.
Sánchez-Aragó M, Formentini L, García-Bermúdez J, Cuezva JM. Sánchez-Aragó M, et al. Among authors: formentini l. Cell Cycle. 2012 Aug 15;11(16):2963-4. doi: 10.4161/cc.21387. Epub 2012 Aug 8. Cell Cycle. 2012. PMID: 22871729 Free PMC article.
Comment on: Formentini L, et al. Mol Cell 2012; 45:731-42....
Comment on: Formentini L, et al. Mol Cell 2012; 45:731-42....
Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers.
Sánchez-Aragó M, Formentini L, Martínez-Reyes I, García-Bermudez J, Santacatterina F, Sánchez-Cenizo L, Willers IM, Aldea M, Nájera L, Juarránz A, López EC, Clofent J, Navarro C, Espinosa E, Cuezva JM. Sánchez-Aragó M, et al. Among authors: formentini l. Oncogenesis. 2013 Apr 22;2(4):e46. doi: 10.1038/oncsis.2013.9. Oncogenesis. 2013. PMID: 23608753 Free PMC article.
Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state.
Santacatterina F, Sánchez-Cenizo L, Formentini L, Mobasher MA, Casas E, Rueda CB, Martínez-Reyes I, Núñez de Arenas C, García-Bermúdez J, Zapata JM, Sánchez-Aragó M, Satrústegui J, Valverde ÁM, Cuezva JM. Santacatterina F, et al. Among authors: formentini l. Oncotarget. 2016 Jan 5;7(1):490-508. doi: 10.18632/oncotarget.6357. Oncotarget. 2016. PMID: 26595676 Free PMC article.
38 results