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Identification of the antigenic epitopes in staphylococcal enterotoxins A and E and design of a superantigen for human cancer therapy.
Erlandsson E, Andersson K, Cavallin A, Nilsson A, Larsson-Lorek U, Niss U, Sjöberg A, Wallén-Ohman M, Antonsson P, Walse B, Forsberg G. Erlandsson E, et al. J Mol Biol. 2003 Nov 7;333(5):893-905. doi: 10.1016/j.jmb.2003.09.009. J Mol Biol. 2003. PMID: 14583188
Staphylococcal enterotoxin H induces V alpha-specific expansion of T cells.
Petersson K, Pettersson H, Skartved NJ, Walse B, Forsberg G. Petersson K, et al. J Immunol. 2003 Apr 15;170(8):4148-54. doi: 10.4049/jimmunol.170.8.4148. J Immunol. 2003. PMID: 12682246
Immunotherapy with tumor-targeted superantigens (TTS) in combination with docetaxel results in synergistic anti-tumor effects.
Sundstedt A, Celander M, Ohman MW, Forsberg G, Hedlund G. Sundstedt A, et al. Int Immunopharmacol. 2009 Aug;9(9):1063-70. doi: 10.1016/j.intimp.2009.04.013. Epub 2009 May 3. Int Immunopharmacol. 2009. PMID: 19410661
The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.
Hedlund G, Eriksson H, Sundstedt A, Forsberg G, Jakobsen BK, Pumphrey N, Rödström K, Lindkvist-Petersson K, Björk P. Hedlund G, et al. Among authors: forsberg g. PLoS One. 2013 Oct 23;8(10):e79082. doi: 10.1371/journal.pone.0079082. eCollection 2013. PLoS One. 2013. PMID: 24194959 Free PMC article.
Cutting edge: Evidence of direct TCR alpha-chain interaction with superantigen.
Pumphrey N, Vuidepot A, Jakobsen B, Forsberg G, Walse B, Lindkvist-Petersson K. Pumphrey N, et al. J Immunol. 2007 Sep 1;179(5):2700-4. doi: 10.4049/jimmunol.179.5.2700. J Immunol. 2007. PMID: 17709482
Furthermore, we show that different SAgs (e.g., SEH and SEA) can simultaneously bind to one TCR by binding the alpha-chain and the beta-chain, respectively. ...
Furthermore, we show that different SAgs (e.g., SEH and SEA) can simultaneously bind to one TCR by binding the alpha-chain and the be …
A Randomized Phase II/III Study of Naptumomab Estafenatox + IFNα versus IFNα in Renal Cell Carcinoma: Final Analysis with Baseline Biomarker Subgroup and Trend Analysis.
Hawkins RE, Gore M, Shparyk Y, Bondar V, Gladkov O, Ganev T, Harza M, Polenkov S, Bondarenko I, Karlov P, Karyakin O, Khasanov R, Hedlund G, Forsberg G, Nordle Ö, Eisen T. Hawkins RE, et al. Among authors: forsberg g. Clin Cancer Res. 2016 Jul 1;22(13):3172-81. doi: 10.1158/1078-0432.CCR-15-0580. Epub 2016 Feb 5. Clin Cancer Res. 2016. PMID: 26851187 Free article. Clinical Trial.
Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer.
Armstrong AJ, Häggman M, Stadler WM, Gingrich JR, Assikis V, Polikoff J, Damber JE, Belkoff L, Nordle Ö, Forsberg G, Carducci MA, Pili R. Armstrong AJ, et al. Among authors: forsberg g. Clin Cancer Res. 2013 Dec 15;19(24):6891-901. doi: 10.1158/1078-0432.CCR-13-1581. Epub 2013 Nov 19. Clin Cancer Res. 2013. PMID: 24255071 Free PMC article. Clinical Trial.
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