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Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors.
Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. Yvert G, et al. Among authors: foss e. Nat Genet. 2003 Sep;35(1):57-64. doi: 10.1038/ng1222. Epub 2003 Aug 3. Nat Genet. 2003. PMID: 12897782
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.
Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. Kwan EX, et al. PLoS Genet. 2013;9(3):e1003329. doi: 10.1371/journal.pgen.1003329. Epub 2013 Mar 7. PLoS Genet. 2013. PMID: 23505383 Free PMC article.
Genetic basis of proteome variation in yeast.
Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Foss EJ, et al. Nat Genet. 2007 Nov;39(11):1369-75. doi: 10.1038/ng.2007.22. Epub 2007 Oct 21. Nat Genet. 2007. PMID: 17952072
Genetic variation shapes protein networks mainly through non-transcriptional mechanisms.
Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Foss EJ, et al. PLoS Biol. 2011 Sep;9(9):e1001144. doi: 10.1371/journal.pbio.1001144. Epub 2011 Sep 6. PLoS Biol. 2011. PMID: 21909241 Free PMC article.
Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats.
Foss EJ, Gatbonton-Schwager T, Thiesen AH, Taylor E, Soriano R, Lao U, MacAlpine DM, Bedalov A. Foss EJ, et al. PLoS Genet. 2019 May 13;15(5):e1008138. doi: 10.1371/journal.pgen.1008138. eCollection 2019 May. PLoS Genet. 2019. PMID: 31083663 Free PMC article.
SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences.
Foss EJ, Lao U, Dalrymple E, Adrianse RL, Loe T, Bedalov A. Foss EJ, et al. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):552-557. doi: 10.1073/pnas.1614781114. Epub 2017 Jan 3. Proc Natl Acad Sci U S A. 2017. PMID: 28049846 Free PMC article.
Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.
Kwan EX, Foss E, Kruglyak L, Bedalov A. Kwan EX, et al. Among authors: foss e. PLoS Genet. 2011 Aug;7(8):e1002250. doi: 10.1371/journal.pgen.1002250. Epub 2011 Aug 25. PLoS Genet. 2011. PMID: 21901113 Free PMC article.
Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.
Thaminy S, Newcomb B, Kim J, Gatbonton T, Foss E, Simon J, Bedalov A. Thaminy S, et al. Among authors: foss e. J Biol Chem. 2007 Dec 28;282(52):37805-14. doi: 10.1074/jbc.M706384200. Epub 2007 Oct 30. J Biol Chem. 2007. PMID: 17977840
Pharmacogenetics: yeast lead the way.
Foss E, Bedalov A. Foss E, et al. Chem Biol. 2006 Mar;13(3):236-8. doi: 10.1016/j.chembiol.2006.03.001. Chem Biol. 2006. PMID: 16638528
Specificity of repeat-induced point mutation (RIP) in Neurospora: sensitivity of non-Neurospora sequences, a natural diverged tandem duplication, and unique DNA adjacent to a duplicated region.
Foss EJ, Garrett PW, Kinsey JA, Selker EU. Foss EJ, et al. Genetics. 1991 Apr;127(4):711-7. Genetics. 1991. PMID: 1827630 Free PMC article.
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