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Structure-activity study of hCGRP8-37, a calcitonin gene-related peptide receptor antagonist.
Mimeault M, Quirion R, Dumont Y, St-Pierre S, Fournier A. Mimeault M, et al. Among authors: fournier a. J Med Chem. 1992 Jun 12;35(12):2163-8. doi: 10.1021/jm00090a003. J Med Chem. 1992. PMID: 1319490
A structure-activity study was carried out to determine the importance of the N-terminal amino acids of hCGRP8-37 in binding and antagonistic activity to CGRP receptors. ...The pharmacological characterization showed that arginine-11 and leucine-12 play a crucial ro
A structure-activity study was carried out to determine the importance of the N-terminal amino acids of hCGRP8-37 in binding and anta
Peptide YY derivatives as selective neuropeptide Y/peptide YY Y1 and Y2 agonists devoided of activity for the Y3 receptor sub-type.
Dumont Y, Cadieux A, Pheng LH, Fournier A, St-Pierre S, Quirion R. Dumont Y, et al. Among authors: fournier a. Brain Res Mol Brain Res. 1994 Oct;26(1-2):320-4. doi: 10.1016/0169-328x(94)90105-8. Brain Res Mol Brain Res. 1994. PMID: 7854062
The analogue [Leu31,Pro34]PYY demonstrated high (nM) affinity in rat frontoparietal cortical membrane preparations (Y1-enriched tissue) and the rabbit saphenous vein (Y1 in vitro bioassay) but only low affinity in a Y2-enriched preparation (rat hippocampus). ...Interesting …
The analogue [Leu31,Pro34]PYY demonstrated high (nM) affinity in rat frontoparietal cortical membrane preparations (Y1-enriched tissue) and …
Neuropeptide Y potentiates selectively the N-methyl-D-aspartate response in the rat CA3 dorsal hippocampus. I. Involvement of an atypical neuropeptide Y receptor.
Monnet FP, Fournier A, Debonnel G, de Montigny C. Monnet FP, et al. Among authors: fournier a. J Pharmacol Exp Ther. 1992 Dec;263(3):1212-8. J Pharmacol Exp Ther. 1992. PMID: 1469629
The peptides NPY (which is active at Y1, Y2 and Y3 receptors), [Leu31, Pro34]NPY (a selective Y1 agonist) and NPY13-36 (which mimics the effects of NPY in Y2 models) dose dependently enhanced NMDA-induced activation of CA3 dorsal hippocampus pyramidal neurons, but did not …
The peptides NPY (which is active at Y1, Y2 and Y3 receptors), [Leu31, Pro34]NPY (a selective Y1 agonist) and NPY13-36 (which mimics …
Conformational and biological studies of neuropeptide Y analogs containing structural alterations.
Fournier A, Gagnon D, Quirion R, Cadieux A, Dumont Y, Pheng LH, St-Pierre S. Fournier A, et al. Mol Pharmacol. 1994 Jan;45(1):93-101. Mol Pharmacol. 1994. PMID: 8302286
In some of these, the missing portion was replaced with epsilon-aminocaproic acid, a flexible arm-linker. Data revealed that (1-4)-Aca-(18-36)NPY is a discontinuous analog almost as potent as the native peptide in a pharmacological preparation enriched in Y2 …
In some of these, the missing portion was replaced with epsilon-aminocaproic acid, a flexible arm-linker. Data revealed that (1-4)-Ac …
A potent and selective CGRP2 agonist, [Cys(Et)2,7]hCGRP alpha: comparison in prototypical CGRP1 and CGRP2 in vitro bioassays.
Dumont Y, Fournier A, St-Pierre S, Quirion R. Dumont Y, et al. Among authors: fournier a. Can J Physiol Pharmacol. 1997 Jun;75(6):671-6. Can J Physiol Pharmacol. 1997. PMID: 9276147
The development of highly selective and potent agonists and antagonists is critical in evaluating the physiological role(s) of each receptor subtype in a peptide family. ...Among them, replacing the acetaminomethyl moiety (Acm) by an ethylamide group, [Cys(Et)2,7]hCGRP alp …
The development of highly selective and potent agonists and antagonists is critical in evaluating the physiological role(s) of each receptor …
Binding profile of a selective calcitonin gene-related peptide (CGRP) receptor antagonist ligand, [125I-Tyr]hCGRP8-37, in rat brain and peripheral tissues.
Van Rossum D, Ménard DP, Fournier A, St-Pierre S, Quirion R. Van Rossum D, et al. Among authors: fournier a. J Pharmacol Exp Ther. 1994 May;269(2):846-53. J Pharmacol Exp Ther. 1994. PMID: 8182554
The calcitonin gene-related peptide (CGRP) C-terminal fragment human CGRP8-37 acts as a potent antagonist of various in vitro and in vivo effects of CGRP. Its iodinated counterpart, [125I-Tyr] hCGRP8-37, binds with high affinity (KD values between 7.5 x 10(-11)-2.1 x 10(-1 …
The calcitonin gene-related peptide (CGRP) C-terminal fragment human CGRP8-37 acts as a potent antagonist of various in vitro and in …
Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity.
Dennis T, Fournier A, St Pierre S, Quirion R. Dennis T, et al. Among authors: fournier a. J Pharmacol Exp Ther. 1989 Nov;251(2):718-25. J Pharmacol Exp Ther. 1989. PMID: 2553933
The radioligand binding characteristics and in vitro biological activities of human calcitonin gene-related peptide (hCGRP) homologs, analogs and fragments have been tested in a variety of preparations in order to determine the structural requirements of the calcitonin gen …
The radioligand binding characteristics and in vitro biological activities of human calcitonin gene-related peptide (hCGRP) homologs, analog …
hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery.
Dennis T, Fournier A, Cadieux A, Pomerleau F, Jolicoeur FB, St Pierre S, Quirion R. Dennis T, et al. Among authors: fournier a. J Pharmacol Exp Ther. 1990 Jul;254(1):123-8. J Pharmacol Exp Ther. 1990. PMID: 2164085
The C-terminal fragment of human calcitonin gene-related peptide (CGRP), hCGRP8-37, fails to induce any biological activity in a variety of isolated tissues and behavioral assays even though it possesses nanomolar affinity for [125I]hCGRP alpha binding sites in the central …
The C-terminal fragment of human calcitonin gene-related peptide (CGRP), hCGRP8-37, fails to induce any biological activity in a vari …
Calcitonin gene-related peptide (hCGRP alpha) binding sites in the nucleus accumbens. Atypical structural requirements and marked phylogenic differences.
Dennis T, Fournier A, Guard S, St Pierre S, Quirion R. Dennis T, et al. Among authors: fournier a. Brain Res. 1991 Jan 18;539(1):59-66. doi: 10.1016/0006-8993(91)90686-p. Brain Res. 1991. PMID: 1849780
A similar distribution was seen in the guinea pig brain albeit of generally higher density. In the rat, very high amounts of [125I]hCGRP alpha binding were seen in the nucleus accumbens while lower levels were found in the striatum and certain cortical areas....
A similar distribution was seen in the guinea pig brain albeit of generally higher density. In the rat, very high amounts of [125I]hC
Structure-activity analysis of CGRP's neurobehavioral effects.
Jolicoeur FB, Menard D, Fournier A, St-Pierre S. Jolicoeur FB, et al. Among authors: fournier a. Ann N Y Acad Sci. 1992 Jun 30;657:155-63. doi: 10.1111/j.1749-6632.1992.tb22764.x. Ann N Y Acad Sci. 1992. PMID: 1637081 No abstract available.
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