Fowler DM - Search Results

1

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.

Starita LM, Pruneda JN, Lo RS, Fowler DM, Kim HJ, Hiatt JB, Shendure J, Brzovic PS, Fields S, Klevit RE. Starita LM, et al. Among authors: fowler dm. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1263-72. doi: 10.1073/pnas.1303309110. Epub 2013 Mar 18. Proc Natl Acad Sci U S A. 2013. PMID: 23509263 Free PMC article.

2

High-resolution mapping of protein sequence-function relationships.

Fowler DM, Araya CL, Fleishman SJ, Kellogg EH, Stephany JJ, Baker D, Fields S. Fowler DM, et al. Nat Methods. 2010 Sep;7(9):741-6. doi: 10.1038/nmeth.1492. Epub 2010 Aug 15. Nat Methods. 2010. PMID: 20711194 Free PMC article.

3

Suppression of statin effectiveness by copper and zinc in yeast and human cells.

Fowler DM, Cooper SJ, Stephany JJ, Hendon N, Nelson S, Fields S. Fowler DM, et al. Mol Biosyst. 2011 Feb;7(2):533-44. doi: 10.1039/c0mb00166j. Epub 2010 Nov 17. Mol Biosyst. 2011. PMID: 21085730 Free PMC article.

4

Enrich: software for analysis of protein function by enrichment and depletion of variants.

Fowler DM, Araya CL, Gerard W, Fields S. Fowler DM, et al. Bioinformatics. 2011 Dec 15;27(24):3430-1. doi: 10.1093/bioinformatics/btr577. Epub 2011 Oct 17. Bioinformatics. 2011. PMID: 22006916 Free PMC article.

5

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function.

Araya CL, Fowler DM, Chen W, Muniez I, Kelly JW, Fields S. Araya CL, et al. Among authors: fowler dm. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16858-63. doi: 10.1073/pnas.1209751109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035249 Free PMC article.

6

Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection.

Gold MG, Fowler DM, Means CK, Pawson CT, Stephany JJ, Langeberg LK, Fields S, Scott JD. Gold MG, et al. Among authors: fowler dm. J Biol Chem. 2013 Jun 14;288(24):17111-21. doi: 10.1074/jbc.M112.447326. Epub 2013 Apr 26. J Biol Chem. 2013. PMID: 23625929 Free PMC article.

7

Deep mutational scanning: a new style of protein science.

Fowler DM, Fields S. Fowler DM, et al. Nat Methods. 2014 Aug;11(8):801-7. doi: 10.1038/nmeth.3027. Nat Methods. 2014. PMID: 25075907 Free PMC article.

8

Measuring the activity of protein variants on a large scale using deep mutational scanning.

Fowler DM, Stephany JJ, Fields S. Fowler DM, et al. Nat Protoc. 2014 Sep;9(9):2267-84. doi: 10.1038/nprot.2014.153. Epub 2014 Aug 28. Nat Protoc. 2014. PMID: 25167058 Free PMC article.

9

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.

Starita LM, Young DL, Islam M, Kitzman JO, Gullingsrud J, Hause RJ, Fowler DM, Parvin JD, Shendure J, Fields S. Starita LM, et al. Among authors: fowler dm. Genetics. 2015 Jun;200(2):413-22. doi: 10.1534/genetics.115.175802. Epub 2015 Mar 30. Genetics. 2015. PMID: 25823446 Free PMC article.

10

Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research.

Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, Cox NJ, Herman GE, Kingsmore S, Lo C, Lutz C, MacRae CA, Nussbaum RL, Ordovas JM, Ramos EM, Robinson PN, Rubinstein WS, Seidman C, Stranger BE, Wang H, Westerfield M, Bult C. Manolio TA, et al. Among authors: fowler dm. Cell. 2017 Mar 23;169(1):6-12. doi: 10.1016/j.cell.2017.03.005. Cell. 2017. PMID: 28340351 Free PMC article.

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