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The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects.
Volkow ND, Wang GJ, Fowler JS, Learned-Coughlin S, Yang J, Logan J, Schlyer D, Gatley JS, Wong C, Zhu W, Pappas N, Schueller M, Jayne M, Carter P, Warner D, Ding YS, Shea C, Xu Y. Volkow ND, et al. Among authors: fowler js. Biol Psychiatry. 2005 Mar 15;57(6):640-6. doi: 10.1016/j.biopsych.2004.12.007. Biol Psychiatry. 2005. PMID: 15780851 Clinical Trial.
Dopamine transporters decrease with age.
Volkow ND, Ding YS, Fowler JS, Wang GJ, Logan J, Gatley SJ, Hitzemann R, Smith G, Fields SD, Gur R. Volkow ND, et al. Among authors: fowler js. J Nucl Med. 1996 Apr;37(4):554-9. J Nucl Med. 1996. PMID: 8691238 Free article.
470 results