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Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.
Helsley RN, Varadharajan V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Orabi D, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM. Helsley RN, et al. Among authors: fox pl. Elife. 2019 Oct 17;8:e49882. doi: 10.7554/eLife.49882. Elife. 2019. PMID: 31621579 Free PMC article.
Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.
Huang Y, Wu Z, Riwanto M, Gao S, Levison BS, Gu X, Fu X, Wagner MA, Besler C, Gerstenecker G, Zhang R, Li XM, DiDonato AJ, Gogonea V, Tang WH, Smith JD, Plow EF, Fox PL, Shih DM, Lusis AJ, Fisher EA, DiDonato JA, Landmesser U, Hazen SL. Huang Y, et al. Among authors: fox pl. J Clin Invest. 2013 Sep;123(9):3815-28. doi: 10.1172/JCI67478. Epub 2013 Aug 1. J Clin Invest. 2013. PMID: 23908111 Free PMC article.
A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.
Gu X, Wu Z, Huang Y, Wagner MA, Baleanu-Gogonea C, Mehl RA, Buffa JA, DiDonato AJ, Hazen LB, Fox PL, Gogonea V, Parks JS, DiDonato JA, Hazen SL. Gu X, et al. Among authors: fox pl. J Biol Chem. 2016 Mar 18;291(12):6386-95. doi: 10.1074/jbc.M115.696088. Epub 2016 Jan 21. J Biol Chem. 2016. PMID: 26797122 Free PMC article.
EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.
Arif A, Terenzi F, Potdar AA, Jia J, Sacks J, China A, Halawani D, Vasu K, Li X, Brown JM, Chen J, Kozma SC, Thomas G, Fox PL. Arif A, et al. Among authors: fox pl. Nature. 2017 Feb 16;542(7641):357-361. doi: 10.1038/nature21380. Epub 2017 Feb 8. Nature. 2017. PMID: 28178239 Free PMC article.
IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
Zhou H, Wang H, Yu M, Schugar RC, Qian W, Tang F, Liu W, Yang H, McDowell RE, Zhao J, Gao J, Dongre A, Carman JA, Yin M, Drazba JA, Dent R, Hine C, Chen YR, Smith JD, Fox PL, Brown JM, Li X. Zhou H, et al. Among authors: fox pl. Nat Immunol. 2020 Oct;21(10):1219-1231. doi: 10.1038/s41590-020-0750-1. Epub 2020 Aug 10. Nat Immunol. 2020. PMID: 32778760 Free PMC article.
176 results