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Joint longitudinal and time-to-event models for multilevel hierarchical data.
Brilleman SL, Crowther MJ, Moreno-Betancur M, Buros Novik J, Dunyak J, Al-Huniti N, Fox R, Hammerbacher J, Wolfe R. Brilleman SL, et al. Stat Methods Med Res. 2019 Dec;28(12):3502-3515. doi: 10.1177/0962280218808821. Epub 2018 Oct 31. Stat Methods Med Res. 2019. PMID: 30378472
Population Exposure-Response Modeling Supported Selection of Naloxegol Doses in Phase III Studies in Patients With Opioid-Induced Constipation.
Al-Huniti N, Xu H, Zhou D, Aksenov S, Fox R, Bui KH. Al-Huniti N, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Oct;6(10):705-711. doi: 10.1002/psp4.12229. Epub 2017 Sep 25. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28782266 Free PMC article. Clinical Trial.
Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL.
Clegg LE, Heerspink HJL, Penland RC, Tang W, Boulton DW, Bachina S, Fox RD, Fenici P, Thuresson M, Mentz RJ, Hernandez AF, Holman RR. Clegg LE, et al. Diabetes Care. 2019 Feb;42(2):318-326. doi: 10.2337/dc18-1871. Epub 2018 Dec 6. Diabetes Care. 2019. PMID: 30523029 Clinical Trial.
Data standards for model-informed drug development: an ISoP initiative.
Radivojevic A, Corrigan B, Downie N, Fox R, Fiedler-Kelly J, Liu H, Melhem M, Radke D, Schaefer P, Su J, Swat MJ, Teuscher NS, Thanneer N, Zong A, Wilkins JJ. Radivojevic A, et al. J Pharmacokinet Pharmacodyn. 2018 Oct;45(5):659-661. doi: 10.1007/s10928-018-9595-8. Epub 2018 Jul 25. J Pharmacokinet Pharmacodyn. 2018. PMID: 30046963 No abstract available.
Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor Positive Allosteric Modulators with Enhanced Drug-Like Properties.
Wold EA, Garcia EJ, Wild C, Miszkiel JM, Soto CA, Chen J, Pazdrak K, Fox RG, Anastasio NC, Cunningham KA, Zhou J. Wold EA, et al. Among authors: Fox RG. J Med Chem. 2020 Jun 22. doi: 10.1021/acs.jmedchem.9b01953. Online ahead of print. J Med Chem. 2020. PMID: 32567857
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