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Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus.
Rode I, Martins VC, Küblbeck G, Maltry N, Tessmer C, Rodewald HR. Rode I, et al. J Immunol. 2015 Dec 15;195(12):5678-87. doi: 10.4049/jimmunol.1502010. Epub 2015 Nov 4. J Immunol. 2015. PMID: 26538393 Free article.
However, data on the Foxn1 protein are virtually lacking. In this study, we developed novel tools to visualize Foxn1 protein expression at single-cell resolution. ...We evaluated Foxn1 expression patterns in TEC subsets and …
However, data on the Foxn1 protein are virtually lacking. In this study, we developed novel tools to visualize Foxn1
Thymus Maintenance and Regeneration by Specific Molecular Factors.
Mendelsohn AR, Larrick JW. Mendelsohn AR, et al. Rejuvenation Res. 2016 Feb;19(1):90-3. doi: 10.1089/rej.2016.1812. Rejuvenation Res. 2016. PMID: 26837468
Caloric restriction or ectopic expression of the pro-longevity growth factor fibroblast growth factor 21 has been reported to maintain the thymus in aging mice. Moreover, forced expression of the transcription factor FoxN1 has been …
Caloric restriction or ectopic expression of the pro-longevity growth factor fibroblast growth factor 21 has been repor …
Regeneration of the aged thymus by a single transcription factor.
Bredenkamp N, Nowell CS, Blackburn CC. Bredenkamp N, et al. Development. 2014 Apr;141(8):1627-37. doi: 10.1242/dev.103614. Development. 2014. PMID: 24715454 Free PMC article.
The effects of upregulating FOXN1 function in the aged thymus are, however, unknown. Here, we show that forced, TEC-specific upregulation of FOXN1 in the fully involuted thymus of aged mice results in robust thymus regeneration characteri …
The effects of upregulating FOXN1 function in the aged thymus are, however, unknown. Here, we show that forced, TEC-specific u …