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The L-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications.
Böger RH, Bode-Böger SM, Frölich JC. Böger RH, et al. Atherosclerosis. 1996 Nov 15;127(1):1-11. doi: 10.1016/s0021-9150(96)05953-9. Atherosclerosis. 1996. PMID: 9006798 Review. No abstract available.
Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir.
Schneider JY, Rothmann S, Schröder F, Langen J, Lücke T, Mariotti F, Huneau JF, Frölich JC, Tsikas D. Schneider JY, et al. Among authors: frolich jc. Amino Acids. 2015 Sep;47(9):1961-74. doi: 10.1007/s00726-015-2031-0. Epub 2015 Jun 28. Amino Acids. 2015. PMID: 26123989 Clinical Trial.
No effects of atorvastatin (10 mg/d or 80 mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study.
Tsikas D, Pham VV, Suchy MT, van de Ree MA, Huisman MV, Frölich JC, Princen HM; DALI-Study Group. Tsikas D, et al. Among authors: frolich jc. Pharmacol Res. 2015 Apr;94:1-8. doi: 10.1016/j.phrs.2015.01.004. Epub 2015 Feb 7. Pharmacol Res. 2015. PMID: 25662039 Clinical Trial.
Oral L-arginine improves endothelial function in healthy individuals older than 70 years.
Bode-Böger SM, Muke J, Surdacki A, Brabant G, Böger RH, Frölich JC. Bode-Böger SM, et al. Vasc Med. 2003 May;8(2):77-81. doi: 10.1191/1358863x03vm474oa. Vasc Med. 2003. PMID: 14518608 Clinical Trial.
Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans.
Kielstein JT, Impraim B, Simmel S, Bode-Böger SM, Tsikas D, Frölich JC, Hoeper MM, Haller H, Fliser D. Kielstein JT, et al. Circulation. 2004 Jan 20;109(2):172-7. doi: 10.1161/01.CIR.0000105764.22626.B1. Epub 2003 Dec 8. Circulation. 2004. PMID: 14662708 Clinical Trial.
The L-arginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: biological and analytical ramifications.
Becker T, Mevius I, de Vries DK, Schaapherder AF, zu Vilsendorf AM, Klempnauer J, Frölich JC, Tsikas D. Becker T, et al. Nitric Oxide. 2009 Feb;20(1):61-7. doi: 10.1016/j.niox.2008.10.002. Epub 2008 Oct 10. Nitric Oxide. 2009. PMID: 18948222
Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometry.
Böger RH, Tsikas D, Bode-Böger SM, Phivthong-Ngam L, Schwedhelm E, Frölich JC. Böger RH, et al. Nitric Oxide. 2004 Aug;11(1):1-8. doi: 10.1016/j.niox.2004.07.008. Nitric Oxide. 2004. PMID: 15350551
Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative.
Tsikas D, Schubert B, Gutzki FM, Sandmann J, Frölich JC. Tsikas D, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Dec 5;798(1):87-99. doi: 10.1016/j.jchromb.2003.09.001. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 14630363
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