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IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.
MacGregor JT, Frötschl R, White PA, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernández LG, Johnson GE, Kasamatsu T, Levy DD, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V. MacGregor JT, et al. Among authors: frotschl r. Mutat Res Genet Toxicol Environ Mutagen. 2015 May 1;783:66-78. doi: 10.1016/j.mrgentox.2014.10.008. Epub 2014 Oct 27. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 25953401 Free article.
IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).
MacGregor JT, Frötschl R, White PA, Crump KS, Eastmond DA, Fukushima S, Guérard M, Hayashi M, Soeteman-Hernández LG, Kasamatsu T, Levy DD, Morita T, Müller L, Schoeny R, Schuler MJ, Thybaud V, Johnson GE. MacGregor JT, et al. Among authors: frotschl r. Mutat Res Genet Toxicol Environ Mutagen. 2015 May 1;783:55-65. doi: 10.1016/j.mrgentox.2014.09.011. Epub 2014 Oct 13. Mutat Res Genet Toxicol Environ Mutagen. 2015. PMID: 25953400 Free article.
In vitro genotoxicity test approaches with better predictivity: summary of an IWGT workshop.
Pfuhler S, Fellows M, van Benthem J, Corvi R, Curren R, Dearfield K, Fowler P, Frötschl R, Elhajouji A, Le Hégarat L, Kasamatsu T, Kojima H, Ouédraogo G, Scott A, Speit G. Pfuhler S, et al. Among authors: frotschl r. Mutat Res. 2011 Aug 16;723(2):101-7. doi: 10.1016/j.mrgentox.2011.03.013. Epub 2011 Apr 5. Mutat Res. 2011. PMID: 21473931
Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs.
Li HH, Chen R, Hyduke DR, Williams A, Frötschl R, Ellinger-Ziegelbauer H, O'Lone R, Yauk CL, Aubrecht J, Fornace AJ Jr. Li HH, et al. Among authors: frotschl r. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10881-E10889. doi: 10.1073/pnas.1714109114. Epub 2017 Dec 4. Proc Natl Acad Sci U S A. 2017. PMID: 29203651 Free PMC article.
Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.
Klaus V, Bastek H, Damme K, Collins LB, Frötschl R, Benda N, Lutter D, Ellinger-Ziegelbauer H, Swenberg JA, Dietrich DR, Stemmer K. Klaus V, et al. Among authors: frotschl r. Arch Toxicol. 2017 Oct;91(10):3427-3438. doi: 10.1007/s00204-017-1953-6. Epub 2017 Mar 27. Arch Toxicol. 2017. PMID: 28349193 Free PMC article.
Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip® assay in TK6 cells.
Buick JK, Rowan-Carroll A, Gagné R, Williams A, Chen R, Li HH, Fornace AJ Jr, Chao C, Engelward BP, Frötschl R, Ellinger-Ziegelbauer H, Pettit SD, Aubrecht J, Yauk CL. Buick JK, et al. Among authors: frotschl r. Front Toxicol. 2022 Sep 23;4:991590. doi: 10.3389/ftox.2022.991590. eCollection 2022. Front Toxicol. 2022. PMID: 36211197 Free PMC article.
The rat bone marrow micronucleus test: Statistical considerations on historical negative control data.
Igl BW, Bitsch A, Bringezu F, Chang S, Dammann M, Frötschl R, Harm V, Kellner R, Krzykalla V, Lott J, Nern M, Pfuhler S, Queisser N, Schulz M, Sutter A, Vaas L, Vonk R, Zellner D, Ziemann C. Igl BW, et al. Among authors: frotschl r. Regul Toxicol Pharmacol. 2019 Mar;102:13-22. doi: 10.1016/j.yrtph.2018.12.009. Epub 2018 Dec 17. Regul Toxicol Pharmacol. 2019. PMID: 30572081
28 results