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27 results
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Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.
Francis JC, Radtke F, Logan MP. Francis JC, et al. Dev Dyn. 2005 Dec;234(4):1006-15. doi: 10.1002/dvdy.20590. Dev Dyn. 2005. PMID: 16245338
Prostate Organogenesis.
Francis JC, Swain A. Francis JC, et al. Cold Spring Harb Perspect Med. 2018 Jul 2;8(7):a030353. doi: 10.1101/cshperspect.a030353. Cold Spring Harb Perspect Med. 2018. PMID: 29229667 Free PMC article. Review.
Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development.
Bryant SL, Francis JC, Lokody IB, Wang H, Risbridger GP, Loveland KL, Swain A. Bryant SL, et al. Among authors: francis jc. Dev Biol. 2014 Nov 15;395(2):209-17. doi: 10.1016/j.ydbio.2014.09.016. Epub 2014 Sep 27. Dev Biol. 2014. PMID: 25261715 Free PMC article.
The role of Sox9 in prostate development.
Thomsen MK, Francis JC, Swain A. Thomsen MK, et al. Among authors: francis jc. Differentiation. 2008 Jul;76(6):728-35. doi: 10.1111/j.1432-0436.2008.00293.x. Epub 2008 Jun 28. Differentiation. 2008. PMID: 18557758 Review.
Pten Regulates Epithelial Cytodifferentiation during Prostate Development.
Lokody IB, Francis JC, Gardiner JR, Erler JT, Swain A. Lokody IB, et al. Among authors: francis jc. PLoS One. 2015 Jun 15;10(6):e0129470. doi: 10.1371/journal.pone.0129470. eCollection 2015. PLoS One. 2015. PMID: 26076167 Free PMC article.
╬▓-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma.
Francis JC, Thomsen MK, Taketo MM, Swain A. Francis JC, et al. PLoS Genet. 2013;9(1):e1003180. doi: 10.1371/journal.pgen.1003180. Epub 2013 Jan 3. PLoS Genet. 2013. PMID: 23300485 Free PMC article.
SOX9 is a driver of aggressive prostate cancer by promoting invasion, cell fate and cytoskeleton alterations and epithelial to mesenchymal transition.
Francis JC, Capper A, Ning J, Knight E, de Bono J, Swain A. Francis JC, et al. Oncotarget. 2018 Jan 10;9(7):7604-7615. doi: 10.18632/oncotarget.24123. eCollection 2018 Jan 26. Oncotarget. 2018. PMID: 29484136 Free PMC article.
Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC).
Welti J, Sharp A, Yuan W, Dolling D, Nava Rodrigues D, Figueiredo I, Gil V, Neeb A, Clarke M, Seed G, Crespo M, Sumanasuriya S, Ning J, Knight E, Francis JC, Hughes A, Halsey WS, Paschalis A, Mani RS, Raj GV, Plymate SR, Carreira S, Boysen G, Chinnaiyan AM, Swain A, de Bono JS; International SU2C/PCF Prostate Cancer Dream Team. Welti J, et al. Among authors: francis jc. Clin Cancer Res. 2018 Jul 1;24(13):3149-3162. doi: 10.1158/1078-0432.CCR-17-3571. Epub 2018 Mar 19. Clin Cancer Res. 2018. PMID: 29555663 Free article.
HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.
Francis JC, Gardiner JR, Renaud Y, Chauhan R, Weinstein Y, Gomez-Sanchez C, Lefran├žois-Martinez AM, Bertherat J, Val P, Swain A. Francis JC, et al. Br J Cancer. 2020 Nov 20. doi: 10.1038/s41416-020-01166-z. Online ahead of print. Br J Cancer. 2020. PMID: 33214683
Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer.
Fletcher CE, Sulpice E, Combe S, Shibakawa A, Leach DA, Hamilton MP, Chrysostomou SL, Sharp A, Welti J, Yuan W, Dart DA, Knight E, Ning J, Francis JC, Kounatidou EE, Gaughan L, Swain A, Lupold SE, de Bono JS, McGuire SE, Gidrol X, Bevan CL. Fletcher CE, et al. Among authors: francis jc. Oncogene. 2019 Jul;38(28):5700-5724. doi: 10.1038/s41388-019-0823-5. Epub 2019 May 1. Oncogene. 2019. PMID: 31043708 Free PMC article.
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